Rabies Vaccine
Mostrando 25-36 de 82 artigos, teses e dissertações.
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25. The use of an E1-deleted, replication-defective adenovirus recombinant expressing the rabies virus glycoprotein for early vaccination of mice against rabies virus.
An E1-deleted, replication-defective adenovirus recombinant of the human strain 5 expressing the rabies virus glycoprotein, termed Adrab.gp, was tested in young mice. Mice immunized at birth with the Adrab.gp construct developed antibodies to rabies virus and cytokine-secreting lymphocytes and were protected against subsequent challenge. Maternal immunity to
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26. Sensitive Procedure for Detecting Residual Viable Virus in Inactivated Rabies Vaccine
A procedure for testing inactivated rabies vaccines of tissue culture origin for residual viable virus is reported in which the vaccine to be tested is passed in primary hamster kidney cell culture (PHK) before mouse inoculation. In preliminary experiments, titrations of rabies virus in which each dilution was passed in PHK before inoculating mice yielded ti
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27. Stimulation of Rabies Vaccine in Mice by Low Doses of Polyadenylic: Polyuridylic Complex
Addition of 100 μg of polyadenylic: polyuridylic (poly A:U) complex to each dose of inactivated rabies vaccine increased immunity to rabies challenge in mice. Stimulation was also observed after addition of 10 μg of poly A:U to the vaccines. Mixtures of rabies vaccine and poly A:U lost their stimulatory properties after storage at 37 or 4 C for 1 month. Ho
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28. Oral immunization and protection of raccoons (Procyon lotor) with a vaccinia-rabies glycoprotein recombinant virus vaccine.
Animal rabies control has been frustrated by the existence of multiple wildlife reservoirs and the lack of efficacious oral vaccines. In this investigation, raccoons fed a vaccinia-rabies glycoprotein recombinant virus in a sponge bait developed rabies virus-neutralizing antibody (0.6-54.0 units) and resisted street rabies virus infection 28 and 205 days aft
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29. Novel, Chimpanzee Serotype 68-Based Adenoviral Vaccine Carrier for Induction of Antibodies to a Transgene Product
An E1-deletion-containing adenoviral recombinant based on the chimpanzee serotype 68 (AdC68) was developed to express the rabies virus glycoprotein. Mice immunized with this construct (AdC68rab.gp) developed antibodies to rabies virus and remained resistant to challenge with an otherwise lethal dose of rabies virus. In naïve mice immunized intranasally, the
American Society for Microbiology.
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30. Recognition of rabies and rabies-related viruses by T cells derived from human vaccine recipients.
Human peripheral blood mononuclear cells and T-cell lines and clones from individuals immunized with rabies PM vaccine were tested for the ability to recognize antigenic determinants in rabies and rabies-related viruses in an antigen-induced proliferation assay. Some, but not all, of the T cells from these individuals cross-reacted with various laboratory st
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31. Immunogenicity of Rabies Virus Inactivated by β-Propiolactone, Acetylethyleneimine, and Ionizing Irradiation
Ionizing radiation, β-propiolactone, and acetylethyleneimine were compared for their ability as virus-inactivating agents for the preparation of rabies vaccine. Each agent reduced viral infectivity exponentially; ionizing radiation also destroyed viral hemagglutinin. The vaccine prepared by ionizing radiation was equal or superior to that prepared by β-pro
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32. Purified Rabies Vaccine (Suckling Rat Brain Origin)
A 10% suckling rat brain rabies vaccine free from encephalitogenic activity was prepared and inactivated with 1:8,000 beta-propiolactone (BPL), or ultraviolet light, or a combination of ultraviolet light and BPL, or 1% phenol. Potency was excellent in all samples, with the exception of the phenolized product which was marginal. A purified suckling rat brain
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33. Effect of Passive Immunization or Maternally Transferred Immunity on the Antibody Response to a Genetic Vaccine to Rabies Virus
A plasmid vector, termed pSG5rab.gp, expressing the glycoprotein of rabies virus was tested in young adult or neonatal mice in the presence of maternally transferred immunity or passively administered antibodies to rabies virus for induction of an antibody response. Mice born to rabies virus-immune dams developed an impaired antibody response to genetic immu
American Society for Microbiology.
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34. Use of Inoculated Eggs as a Vehicle for the Oral Rabies Vaccination of Red Foxes (Vulpes fulva)
The ERA vaccine strain of rabies virus propagated on continuous porcine kidney tissue culture cells (PK15) was inoculated into the yolk sac of embryonated chicken eggs for the purpose of oral vaccine distribution. Two inoculated eggs were subsequently fed to each of 12 serologically rabies-negative foxes. Six (50%) of the foxes developed demonstrable rabies
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35. Antibody Response to a Human Diploid Cell Rabies Vaccine
An experimentally killed rabies virus vaccine prepared in a human diploid cell strain (WI-38)—Wyeth rabies vaccine (WRV)—was used by various injection schedules in two separate studies to define more closely in human volunteer subjects an effective vaccination schedule for pre- or postexposure immunization, particularly for donors of rabies-hyperimmune p
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36. Interleukin 2 acts as an adjuvant to increase the potency of inactivated rabies virus vaccine.
Interleukin 2 (IL-2) occupies a central position in the cascade of events involved in the immune response. We were interested in determining whether IL-2 could function as an adjuvant to vaccination, to increase the immune response to vaccine immunogens. Using the National Institutes of Health test for rabies vaccine potency, we found that daily systemic adm