Purine Nucleotides
Mostrando 1-12 de 263 artigos, teses e dissertações.
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1. Effects of purine nucleotide administration on purine nucleotide metabolism in brains of heroin-dependent rats
ABSTRACT Heroin is known to enhance catabolism and inhibit anabolism of purine nucleotides, leading to purine nucleotide deficiencies in rat brains. Here, we determined the effect of exogenous purine nucleotide administration on purine nucleotide metabolism in the brains of heroin-dependent rats. Heroin was administrated in increasing doses for 9 consecutive
Braz. J. Pharm. Sci.. Publicado em: 2016-12
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2. Ectonucleotidase activities in Sertoli cells from immature rats
Sertoli cells have been shown to be targets for extracellular purines such as ATP and adenosine. These purines evoke responses in Sertoli cells through two subtypes of purinoreceptors, P2Y2 and PA1. The signals to purinoreceptors are usually terminated by the action of ectonucleotidases. To demonstrate these enzymatic activities, we cultured rat Sertoli cell
Publicado em: 2010
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3. Purine nucleotides reduce superoxide production by nitric oxide synthase in a murine sepsis model
Sepsis involves a systemic inflammatory response of multiple endogenous mediators, resulting in many of the injurious and sometimes fatal physiological symptoms of the disease. This systemic activation leads to a compromised vascular response and endothelial dysfunction. Purine nucleotides interact with purinoceptors and initiate a variety of physiological p
Brazilian Journal of Medical and Biological Research. Publicado em: 02/10/2009
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4. Efeito dos diferentes níveis de nucleotídeos em frangos de corte alimentados com probióticos / Effect of the different nucleotides levels in broiler chickens fed with probitics
The objective of this experiment was to evaluate the influence of different nucleotides levels in the rations of broilers containing probiotics on response of the birds and its influence on the performance. Birds were allocated in a randomized experimental design with five replications of each treatment. It was used 1,050 chicks of a day of age, males, distr
Publicado em: 2009
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5. Adenylosuccinate Lyase from Leishmania major Friedlin and its role in the purine nucleotides salvage pathway / Adenylosuccinato lyase (ADSL) de leishmania major friedlin: sua relevância na via de recuperação de purino-nucleotídeos
Many species of Leishmania are responsible for serious visceral or skin diseases that exhibit high incidence in tropical and subtropical regions. The drugs currently employed in the treatment of parasitic diseases are potentially carcinogenic, often require prolonged treatment and patient hospitalization. An effective program of drug design requires the vali
Publicado em: 2006
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6. Time course evaluation of vascular tonus and superoxide production from isolated purines in aorta of endotoxemics Wistar rats / "Avaliação temporal da regulação do tônus vascular e da produção de superóxido induzido por purinas em aorta isolada de ratos Wistar endotoxêmicos"
Septic patients can evolve for septic shock and 40% of these survive. We characterize the experimental model we evaluate involved factors in the inflammation and evaluate the modulation caused by purines (ATP/ADP) in the superoxide quantification (O2-) and in the vascular reactivity of isolated aorta. The results suggest that in isolated aorta of endotoxemic
Publicado em: 2005
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7. Molecular studies of the phosphoribosyl pyrophosphate synthetases / Estudos moleculares das fosforribosil pirofosfato sintetases
Fosforribosil pirofosfato (PRPP) sintetases são enzimas de central importância em diversas vias metabólicas em todas as células. A enzima PRPP sintetase humana é constituída por um complexo composto de três subunidades catalíticas (PRSI, PRSII e PRSIII) e por proteínas homólogas de 39 e 41 kDa denominadas PRS Associated Proteins (PAPs) cuja funçã
Publicado em: 2004
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8. Proteina desacopladora de plantas : efeito do estresse oxidativo na sua expressão e atividade e reconstituição funcional da isoforma de Arabidopsis thaliana
The present work is divided in two parts: the functional reconstitution of the Arabidopsis thaZiana uncoupling protein 1 (AtPUMPI) and the expression and activity of the uncoupling protein under several abiotic stresses. AtPUMPI expression in Saccharomyces cerevisae and Escherichia coZi allowed us to confirm that this gene codes for a true uncoupling protein
Publicado em: 2003
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9. Caracterização de uma proteina de 35 KDa isolada de mitocondrias de batata com possivel função termogenica
Early studles from thls laboratory have lndicated that the low degree of coupling between respiration and oxidative phosphorylation in potato mitochondria seems to be related to a 35 KDa protein, present in the inner membrane of those mitochondria, with the ability to translocate H with a: mechanism sensitive to purine nucleotides. In this work, we obtained
Publicado em: 1993
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10. Basis for the control of purine biosynthesis by purine ribonucleotides.
An animal model was used to determine the basis for the increase in purine biosynthesis that results from hepatic depletion of purine nucleotides, such as seen in patients with type I glycogen storage disease or following fructose administration. Mice were injected intravenously with glucose or fructose, 2.5 mg/g of body weight, and the animals were killed a
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11. Enzymes of Purine Metabolism in Mycoplasma mycoides subsp. mycoides
The major pathways of ribonucleotide biosynthesis in Mycoplasma mycoides subsp. mycoides were proposed previously from studies of its usage of radioactive purines and pyrimidines. To interpret more fully the pattern of purine usage, we have assayed cell-free extracts of this organism for several enzymes associated with the salvage synthesis of purine nucleot
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12. Synthesis and salvage of purines during cellular morphogenesis of Myxococcus xanthus.
Intact cells of Myxococcus xanthus were examined for de novo purine synthesis and salvage utilization. The cellular uptake rates of radioactive glycine (de novo purine precursor), adenine, and guanine were measured, and thin-layer chromatography and radioautography were used to examine cell extracts for de novo synthesized purine nucleotides. Intact vegatati