Pseudohermaphroditism
Mostrando 1-12 de 23 artigos, teses e dissertações.
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1. ANÁLISE MOLECULAR DO GENE DO RECEPTOR DE ANDRÓGENOS EM HOMENS COM SUSPEITA DE INFERTILIDADE
Andrógeno é um termo genérico geralmente utilizado para descrever um grupo de hormônios esteroides sexuais. Os andrógenos são produzidos no homem primariamente pelos testículos. No entanto, algumas pequenas quantidades são também produzidas pelos ovários nas mulheres e pelas glândulas adrenais, em ambos os sexos. Os andrógenos são responsáveis
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 11/01/2010
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2. Clinical, pathological and morphometric study of ten male disgenetic pseudohermaphroditism (DSD 46,XY) / Estudo investigativo clínico, laboratorial, patológico, morfométrico, molecular de 10 pacientes com pseudohermafroditismo masculino disgenético (ADS 46, XY)
O Pseudohermafroditismo masculino disgenético (Anomalia da diferenciação sexual 46,XY ADS 46,XY) é definido como ambigüidade genital num paciente com testículos e/ou cariótipo 46,XY com uma das seguintes características: alteração histológica testicular, ausência ou hipoplasia das células de Leydig em tecido previamente estimulado com gonadotrof
Publicado em: 2010
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3. Estudo dos genes SRD5A2 e 17BHSD3 em casos de ambiguidade genital em pacientes com cariótipo 46,XY / Molecular analysis of the genes SRD5A2 and 17BHSD3 in patients with ambiguous genitalia and kariotype 46, XY
Para um correto desenvolvimento sexual masculino em humanos, é necessária a presença, entre outros, de dois hormônios esteróides: a testosterona (T) e a diidrotestosterona (DHT). A T é o hormônio responsável pelo desenvolvimento da genitália interna masculina, já a DHT é o hormônio chave da virilização da genitália externa masculina e respons�
Publicado em: 2010
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4. Male Pseudohermaphroditism in a Child with Down's Syndrome
A case of male pseudohermaphroditism in a child with Down's syndrome is reported. The patient had infantile testis, ambiguous genitalia, and no apparent internal female genitalia indicating a failure of either gonadal function or end-organ response.
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5. Hereditary Male Pseudohermaphroditism Associated with an Unstable Form of 5α-Reductase
The properties of 5α-reductase have been compared in genital skin fibroblasts cultured from five patients from three families (Los Angeles, Dallas, and Dominican Republic) in which hereditary male pseudohermaphroditism has been established to result from deficient conversion of testosterone to dihydrotestosterone.
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6. Dihydrotestosterone binding by cultured human fibroblasts. Comparison of cells from control subjects and from patients with hereditary male pseudohermaphroditism due to androgen resistance.
Dihydrotestosterone binding was measured in culture fibroblasts from 14 control subjects and from 12 patients with five different types of hereditary male pseudohermaphroditism. Two assays of binding were used--an intact monolayer assay and density gradient centrifugation of cell extracts. In the intact monolayer assay of normal cells the uptake of [3H]dihyd
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7. A CASE OF PSEUDOHERMAPHRODITISM
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8. Pseudohermaphroditism with clinical features of trisomy 19 in an infant trisomic for parts of chromosomes 16 and 18: 47,XY,der(18),t(16;18)(p12;q11)mat.
The case is presented of an infant who was diagnosed clinically as trisomy 18 with pseudohermaphroditism. Cytogenetic studies revealed an extra chromosome which represented a translocation chromosome derived from a balanced, reciprocal translocation between chromosomes 16 and 18: [der(18),t(16;18)(p12;q11)mat]. The infant's mother and a number of her relativ
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9. PSEUDOHERMAPHRODITISM, ADIPOSITY, POLYURIA, AND HYPERGLYCÆMIA. AN INFUNDIBULOTUBERIAN SYNDROME
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10. Male pseudohermaphroditism resulting from a novel mutation in the human steroid 5 alpha-reductase type 2 gene (SRD5A2).
The enzyme steroid 5 alpha-reductase, via NADPH, catalyses the conversion of testosterone to dihydrotestosterone, which is required for the embryonic differentiation of the external male genitalia and the prostate. An impairment of this reaction causes a form of male pseudohermaphroditism in which genetic males differentiate predominantly as phenotypic femal
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11. Male pseudohermaphroditism due to 17α-hydroxylase deficiency
This is the first report of a male with 17α-hydroxylase deficiency resulting in male pseudohermaphroditism, ambiguous external genitalia, absence of male secondary sexual characteristics, and gynecomastia at puberty. Diagnosis was based on extensive studies of steroid metabolism including the following: low urinary excretion of 17-ketosteroids and 17-hydrox
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12. Studies on the pathogenesis of the pseudohermaphroditism in the mouse with testicular feminization
The pathogenesis of the male pseudohermaphroditism in the mouse with X-linked testicular feminization (Tfm) has been investigated by comparing testosterone formation, the effects of androgen administration, and the metabolism of testosterone-1,2-3H in normal mice and Tfm mice of varying ages. First, it was established that the adult Tfm animal, in contrast t