Proteoglycans
Mostrando 1-12 de 381 artigos, teses e dissertações.
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1. Comparison of the effects of triamcinolone acetonide or platelet-rich plasma on expression of extracellular matrix-related genes in equine healthy chondrocytes in vitro
RESUMO: Na cartilagem saudável, os condrócitos mantêm a expressão de colágenos e proteoglicanos, sendo sensíveis a fatores de crescimento e citocinas que aumentam ou reduzem a síntese de colágeno tipo II. Na osteoartrite, citocinas pró-inflamatórias, como a IL-6, estimulam a expressão de metaloproteinases (MMP) e reduzem a síntese de agrecano. O
Cienc. Rural. Publicado em: 04/07/2019
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2. Extracellular diffusion quantified by magnetic resonance imaging during rat C6 glioma cell progression
Solution reflux and edema hamper the convection-enhanced delivery of the standard treatment for glioma. Therefore, a real-time magnetic resonance imaging (MRI) method was developed to monitor the dosing process, but a quantitative analysis of local diffusion and clearance parameters has not been assessed. The objective of this study was to compare diffusion
Braz J Med Biol Res. Publicado em: 03/07/2017
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3. GLYCOSAMINOGLYCANS AND PROTEOGLYCANS IN PALMAR FASCIA OF PATIENTS WITH DUPUYTREN
Objective : To evaluate and compare the behavior of glycosaminoglycans (GAGs) in Dupuytren disease (DD). Methods : This is an experimental study with 23 patients diagnosed with DD. Tissue collected through fasciectomy with incision type Brunner or McCash were evaluated by electrophoresis for identification of GAGs. The quantification was carried out by imm
Acta ortop. bras.. Publicado em: 2016-04
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4. Delivery of the Sox9 gene promotes chondrogenic differentiation of human umbilical cord blood-derived mesenchymal stem cells in an in vitro model
SRY-related high-mobility-group box 9 (Sox9) gene is a cartilage-specific transcription factor that plays essential roles in chondrocyte differentiation and cartilage formation. The aim of this study was to investigate the feasibility of genetic delivery of Sox9 to enhance chondrogenic differentiation of human umbilical cord blood-derived mesenchymal stem ce
Braz J Med Biol Res. Publicado em: 18/03/2014
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5. Immunohistochemical expression of biglycan and decorin in the pulp tissue of human primary teeth during resorption
Primary teeth are interesting models that can be used to study physiological and pathological processes involving cells and extracellular matrices in hard and soft tissues. This study investigated the expression and distribution of biglycan and decorin-the non-collagenous components of the extracellular matrix-in primary teeth tissue, during physiological ro
Braz. oral res.. Publicado em: 2013-09
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6. Avaliação do metabolismo de glicosaminoglicanos em pacientes portadores de cistite intersticial / Evaluation of the metabolism of glycosaminoglycans in patients with interstitial cystitis
Introduction: interstitial cystitis is a chronic disease of the lower urinary tract whose symptoms are: increased urinary frequency, nocturia, perineal or pelvic pain that worses with bladder filling and improves with urination. The pathogenesis is not fully known, but there is evidence that proteoglycans and glycosaminoglycans lining the bladder urothelium
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 12/12/2012
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7. Mycobacterial laminin-binding histone-like protein mediates collagen-dependent cytoadherence
When grown in the presence of exogenous collagen I, Mycobacterium bovis BCG was shown to form clumps. Scanning electron microscopy examination of these clumps revealed the presence of collagen fibres cross-linking the bacilli. Since collagen is a major constituent of the eukaryotic extracellular matrices, we assayed BCG cytoadherence in the presence of exoge
Mem. Inst. Oswaldo Cruz. Publicado em: 2012-12
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8. Construction of a vector for controlled expression of chondroitinase AC for mesenchymal stem cells / Construção de um vetor para expressão controlada de condroitinase AC por células tronco mesenquimais/
Adult mammal axons fail to regenerate when damaged, generating a fundamental problem, inhibiting the recovery of injured central nervous system (CNS). The lack of full regenerative capacity of the injured CNS is due to a glial scar formation on the injury site. The glial scar is formed by astrocytes, oligodendrocyte precursor cells, and microglia, cells that
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 22/02/2011
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9. Heparanase isoform expression and extracellular matrix remodeling in intervertebral disc degenerative disease
OBJECTIVE: To determine the molecules involved in extracellular matrix remodeling and to identify and quantify heparanase isoforms present in herniated and degenerative discs. INTRODUCTION: Heparanase is an endo-beta-glucuronidase that specifically acts upon the heparan sulfate chains of proteoglycans. However, heparanase expression in degenerative intervert
Clinics. Publicado em: 2011
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10. Noncrystalline uric acid inhibits proteoglycan and glycosaminoglycan synthesis in distal tubular epithelial cells (MDCK)
Hyperuricemia is associated with renal stones, not only consisting of uric acid (UrAc) but also of calcium oxalate (CaOx). Glycosaminoglycans (GAGs) are well-known inhibitors of growth and aggregation of CaOx crystals. We analyzed the effect of noncrystalline UrAc on GAG synthesis in tubular distal cells. MDCK (Madin-Darby canine kidney) cells were exposed t
Brazilian Journal of Medical and Biological Research. Publicado em: 2010-10
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11. Quantitative evaluation of experimental choroidal neovascularization by confocal scanning laser ophthalmoscopy: fluorescein angiogram parallels heparan sulfate proteoglycan expression
The objective of the present study was to develop a quantitative method to evaluate laser-induced choroidal neovascularization (CNV) in a rat model using Heidelberg Retina Angiograph 2 (HRA2) imaging. The expression of two heparan sulfate proteoglycans (HSPG) related to inflammation and angiogenesis was also investigated. CNV lesions were induced with argon
Brazilian Journal of Medical and Biological Research. Publicado em: 2010-07
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12. Reação estromal e proteoglicanos de baixo peso molecular ricos em leucina / Stromal reaction and low molecular weight proteoglycans leucine-rich
During cancer cell growth many tumors exhibit various grades of desmoplasia, unorganized production of fibrous or connective tissue, composed mainly of collagen fibers and myofibroblasts. The accumulation of extracellular matrix (ECM) surrounding tumors directly affects cancer cell proliferation, migration and spread, therefore the study of desmoplasia is of
Publicado em: 2010