Proteins Biological Models
Mostrando 13-24 de 65 artigos, teses e dissertações.
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13. Genic transfer in sperm cells in Mus musculus and Ramdia quelem / Transferência gênica em células espermáticas de Mus musculus e Ramdia quelen
Transgenic animals have been used as biological models in studies of the genes functions and their mechanisms of action, as well as to improve animal production. Researchers are trying to produce transgenic animals that will be organs donors in xenotransplants. Another use of the transgenic animal is in the production of recombinant proteins for pharmaceutic
Publicado em: 2009
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14. Computationalmethods for the identification of transcriptional regulationmodules
Recent studies have demonstrated that biological networks display non-random characteristics, among which we highlight the modular architecture. In our thesis, we are interested in the modular organisation of transcriptional regulation networks (TRN), which model the interactions between genes and proteins that control their expression at the transcriptional
Publicado em: 2008
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15. SimAffling um ambiente computacional para suporte e simulação do processo de DNA shuffling
The Molecular Evolution of the living organisms is a slow process that occurs over the years producing mutations and recombinations at the genetic material, i.e. at the DNA. The mutations can occur as nucleotide remotion, insertion and/or substitution at the DNA chain. The Directed Molecular Evolution is an in vitro process that tries to improve biological f
Publicado em: 2008
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16. Caracterização funcional de uma xiloglucano galactosiltransferase de Eucalyptus grandis e uma ramnose sintase de Arabidopsis thaliana: Efeitos sobre a estrutura e composição da parede celular primária / Functional characterization of a xyloglucan galactosyltransferase of Eucalyptus grandis and a rhamnose synthase of Arabidopsis thaliana: Effects upon the structure and composition of the primary cell wall
The plant cell wall has been associated with several important biological functions. It surrounds the plant, protecting it against mechanical injuries, biotic and abiotic stresses. In addition, plant cell walls determine cell shape and growth rates. The main constituents of plant cell walls are: cellulose, hemicellulose, pectine, lignin and proteins, which v
Publicado em: 2008
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17. Serum amyloid A: biological effects on mononuclear cells / Amilóide sérica A: efeitos biológicos sobre células mononucleares
In the past few years, our research group has described various effects of serum amyloid A (SAA) on cells of the immune system regarding the expression and release of pro-inflammatory cytokines. In this study we have focused on the effects of SAA on mononuclear cells. In order to do this, we have used three experimental models. In the murine experimental mod
Publicado em: 2008
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18. Identificação de marcadores moleculares para células T reguladoras humanas com perfil CD4+CD25+ por phage display / Peptide phage display for the identification of novel molecular markers on human thymic regulatory CD4+CD25+ T cells
There are consistent data in literature indicating that thymic CD4+CD25+ cells play an important role in immune regulation and are continuously developed as an independent lineage in the thymus. These cells are known as natural regulatory T cells. Several questions about these cells remain unanswered, such as how they are generated, what is determinant in th
Publicado em: 2008
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19. Study of conformational changes of macromolecules in solutions using X-ray scattering / Estudo de mudanças conformacionais de macromoleculas em solução usando espalhamento de raio-X
During the last decades, the study of conformational changes in biological macromolecules has been a great challenge for the scientists, and continues to be an important subject of biotechnological interest and protein engineering. The process of folding (unfolding) of protein molecules has been intensively studied, because this investigation can contribute
Publicado em: 2007
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20. Isolamento e caracterização de toxinas do veneno de Bothrops alcatraz Marques, Martins e Sazima, 2002 e aspectos coevolutivos com a dieta / Isolation and characterization of toxins of Bothrops alcatraz Marques, Martins e Sazima, 2002 venom and coevolutive aspects with diet
Snakes venoms are complex mixtures with varied composition constituted by organic and inorganic molecules. The main organic components are proteins, which can be toxic and show high enzymatic activities, thus playing important role in prey capture and digestion in snakes. Viperidae snakes family show wide range of biological actions, as proteolytic, coagulan
Publicado em: 2007
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21. Aspectos do envelhecimento cerebral e função cognitiva em modelo experimental animal e estudo de mecanismos de neurodegeneração em cultura celular
The two phenomena, biological and behavioural, approached in the present work are brain aging and spatial memory. Several studies, comparative and experimental, have shown that aged subjects present significantly impaired performances in different types of cognitive tasks. It is also known that contradictions in literature exist in relation to consequences o
Publicado em: 2007
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22. MITOCHONDRIAL PROTEIN EXPRESSION IN NATURAL AND INDUCED FORMS OF CANINE DILATED CARDIOMYOPATHY
Idiopathic dilated cardiomyopathy (DCM) is now widely regarded as a syndrome in which a variety of etiological and predisposing factors give rise to myocardial dysfunction ultimately reflected in a similar pathological condition. DCM is the most well-known myocardial disease in dogs characterized by ventricular dilation and diminished cardiac function. The p
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 2005
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23. QUANTIFICATION OF REDUCED GLUTATHIONE IN HUMAN ERYTHROCYTES BY HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY-UV: VALIDATION AND APLICATION / QUANTIFICAÇÃO DA GLUTATIONA REDUZIDA EM ERITRÓCITOS HUMANOS POR CROMATOGRAFIA LÍQUIDA DE ALTA EFICIÊNCIA-UV: VALIDAÇÃO E APLICAÇÃO
Oxidative stress may be initiated by a decline in the antioxidant defence system or by an overproduction of free radicals leading to an imbalance between oxidants and antioxidants. The most significant alteration in the antioxidant defence is a decrease in reduced glutathione (GSH) concentration. GSH depletion is linked to a number of disease states; includi
Publicado em: 2005
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24. "Avaliação histológica da reparação óssea induzida por osso bovino desmineralizado, em defeitos bicorticais na mandíbulas de ratos, com ou sem membranas de colágeno cálcicas" / Histological evaluation of bone healing induced by demineralized bovine bone, in bicortical defects of rat mandibles, with or without calcic collagen membranes
The use of demineralized bone (DB), in special from bovine source, has been evaluated extensively in experimental models; however, doubts exist if there is sufficient quantity of bone morphogenetic proteins (BMP) to induce the bone repairing. The combination of membranes avoids the encapsulating of DB particles and also it could prevent the early dissolution
Publicado em: 2004