Protease Inhibitor
Mostrando 13-24 de 1173 artigos, teses e dissertações.
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13. Long term effect of switching to darunavir/ritonavir in HIV infected patients previously on protease inhibitor therapy
Braz J Infect Dis. Publicado em: 2016-08
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14. Predictors of early treatment discontinuation and severe anemia in a Brazilian cohort of hepatitis C patients treated with first-generation protease inhibitors
The aim of this study was to determine risk factors for adverse events (AE)-related treatment discontinuation and severe anemia among patients with chronic hepatitis C virus (HCV) genotype 1 infection, treated with first-generation protease inhibitor (PI)-based therapy. We included all patients who initiated treatment with PI-based therapy at a Brazilian uni
Braz J Med Biol Res. Publicado em: 23/06/2016
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15. Antiretroviral drugs saquinavir and ritonavir reduce inhibitory concentration values of itraconazole against Histoplasma capsulatum strains in vitro
Abstract Recent studies have shown that some drugs that are not routinely used to treat fungal infections have antifungal activity, such as protease inhibitor antiretroviral drugs. This study investigated the in vitro susceptibility of Histoplasma capsulatum var. capsulatum to saquinavir and ritonavir, and its combination with the antifungal itraconazole. Th
Braz J Infect Dis. Publicado em: 2016-04
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16. Extraction, purification and characterization of inhibitor of trypsin from Chenopodium quinoa seeds
Abstract A novel trypsin inhibitor of protease (CqTI) was purified from Chenopodium quinoa seeds. The optimal extracting solvent was 0.1M NaCl pH 6.8 (p < 0.05). The extraction time of 5h and 90 °C was optimum for the recovery of the trypsin inhibitor from C. quinoa seeds. The purification occurred in gel-filtration and reverse phase chromatography. CqTI pr
Food Sci. Technol. Publicado em: 03/10/2015
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17. First serine protease inhibitor isolated from Rhinella schneideri poison
Background Toad secretions are a source of molecules with potential biotechnological application on a wide spectrum of diseases. Toads from theRhinella family have two kinds of poisonous glands, namely granular and mucous glands. Rhinella schneideritoads produce granular secretions that comprise a great number of molecules, including serine proteases inhibit
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 29/09/2015
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18. In vivo assessment of antiretroviral therapy-associated side effects
Antiretroviral therapy has been associated with side effects, either from the drug itself or in conjunction with the effects of human immunodeficiency virus infection. Here, we evaluated the side effects of the protease inhibitor (PI) indinavir in hamsters consuming a normal or high-fat diet. Indinavir treatment increased the hamster death rate and resulted
Mem. Inst. Oswaldo Cruz. Publicado em: 23/06/2014
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19. Virologic and immunologic effectiveness of darunavir-based salvage therapy in HIV-1-infected adults in a Brazilian clinical practice setting: results of a multicenter and retrospective cohort study
Background: Darunavir has been proven efficacious for antiretroviral-experienced HIV-1-infected patients in randomized trials. However, effectiveness of darunavir-based salvage therapy is understudied in routine care in Brazil. Methods: Retrospective cohort study of HIV-1-infected patients from three public referral centers in Belo Horizonte, who received
Braz J Infect Dis. Publicado em: 2014-01
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20. A literature review on cardiovascular risk in human immunodeficiency virus-infected patients: implications for clinical management
INTRODUCTION: In recent years, there has been growing concern about an increasing rate of cardiovascular diseases in human immunodeficiency virus-infected patients, which could be associated with side effects of highly active antiretroviral therapy. It is likely that the metabolic disorders related to anti-human immunodeficiency virus treatment will eventual
Braz J Infect Dis. Publicado em: 2013-12
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21. Purification and characterization of a trypsin inhibitor with antimicrobial activity from Jatropha cake (Jatropha curcas L.) / PurificaÃÃo e caracterizaÃÃo de um inibidor de tripsina com atividade antimicrobiana da torta de pinhÃo-manso (Jatropha curcas L.)
O resÃduo (torta) obtido apÃs a extraÃÃo de Ãleo das sementes de pinhÃo-manso (Jatropha curcas) para a produÃÃo de biodiesel à tÃxico. Apesar dos entraves relacionados à sua utilizaÃÃo na alimentaÃÃo animal, existem evidÃncias de que esse resÃduo tem grande potencial de utilizaÃÃo biotecnolÃgica graÃas ao arsenal de molÃculas que o cons
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 29/02/2012
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22. Purificação e caracterização biológica de uma nova serinoprotease com atividade trombina"like" do veneno total de Brothrops andianus (TLBan) / Purification and biological characterization of a new serine protease with thrombin "like" activity the whole venom of Brothrops andianus (TLBan)
In this word, a new serine protease with thrombin "like" activity the venom of Bothrops andianus (TLBan), snake of the Andes of Peru, was isolated by two steps: molecular exclusion chromatography G-75 and liquid chromatography in reversed-phase HPLC; with a high degree of purity and molecular homegenidade. Through of electrophoresis on SDS-PAGE shows the TLB
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 27/02/2012
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23. Transcriptome analysis of resistant soybean roots infected by Meloidogyne javanica
Soybean is an important crop for Brazilian agribusiness. However, many factors can limit its production, especially root-knot nematode infection. Studies on the mechanisms employed by the resistant soybean genotypes to prevent infection by these nematodes are of great interest for breeders. For these reasons, the aim of this work is to characterize the trans
Genet. Mol. Biol.. Publicado em: 2012
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24. PrevalÃncia dos subtipos do vÃrus da imunodeficiÃncia humana do tipo 1 (HIV-1) no estado do Piauà - Brasil e o perfil de resistÃncia das cepas identificadas. / Subtipes prevalence of human imunodeficient virus type 1 (HIV-1) in Piauà state/Brazil and the resistance profile of the studies virus.
HIV-1 genetic variability is a wellkown problem that makes diagnosis and treatment difficult to manage. Also, this variability is a problem for trasmission, disease progression and for the development of vaccines, being important to know the subtypes presented in each population worldwilde and in Brazil to provide more effective treatment. The present study
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 07/10/2011