Prostaglandin And Endothelin 1
Mostrando 1-12 de 14 artigos, teses e dissertações.
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1. The effects of inhaled NO on plasma vasoactive factor and CTnI level in rabbits with acute massive pulmonary embolism
Abstract Purpose: To investigate changes in the plasma concentrations of cardiac troponin I (CTnI), thromboxane A2 (TXA2), prostaglandin I2 (PGI2) and endothelin-1 (ET-1) in rabbits with massive pulmonary embolism (AMPE) and the impact of nitric oxide inhalation (NOI) on these indices. Methods: A total of 30 Japanese rabbits were used to construct an MPE
Acta Cir. Bras.. Publicado em: 2018-07
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2. Efeitos das isoflavonas da soja (Glycine max) na síntese de fatores vasoativos derivados de células endoteliais humanas da linhagem ECV304 / Effects of soy isoflavones (Glycine max) in the synthesis of vasoactive factors derived from human endothelial cells line ECV304.
During their reproductive years, women have a lower incidence of coronary heart disease (CHD) compared to men of similar age. However, this advantage disappears in post-menopause, suggesting that female sex hormones exert some cardio protective effect. One of the mechanisms proposed to explain this protection is the fact that estrogens promote the production
Publicado em: 2008
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3. Gap junctions in isolated rat aorta: evidence for contractile responses that exhibit a differential dependence on intercellular communication
Connexin43 (Cx43) is a major gap junction protein present in the Fischer-344 rat aorta. Previous studies have identified conditions under which selective disruption of intercellular communication with heptanol caused a significant, readily reversible and time-dependent diminution in the magnitude of a1-adrenergic contractions in is
Brazilian Journal of Medical and Biological Research. Publicado em: 2000-04
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4. Caracterização farmacologica dos receptores de endotelina na circulação portal de figado isolado de cão
Endothelins constitute a family of vasoactive mediators, capable of producing potent and long-lasting pressor responses in several vascular territories. Endothelin-1 has been implicated in the regulation of resistance to portal blood flow, particularly in the presence of cirrhosis and portal hypertension. However, the receptor subtypes mediating this phenome
Publicado em: 1997
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5. Growth inhibitory properties of endothelin-1 in activated human hepatic stellate cells: a cyclic adenosine monophosphate-mediated pathway. Inhibition of both extracellular signal-regulated kinase and c-Jun kinase and upregulation of endothelin B receptors.
During chronic liver diseases, hepatic stellate cells (HSC) acquire an activated myofibroblast-like phenotype, proliferate, and synthetize fibrosis components. We have shown that endothelin-1 (ET-1) inhibits the proliferation of activated human HSC via endothelin B (ETB) receptors. We now investigate the transduction pathway involved in the growth inhibitory
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6. Luminal and basolateral endothelin inhibit chloride reabsorption in the mouse thick ascending limb via a Ca(2+)-independent pathway.
1. The recent localization of endothelin synthesis and receptors in the thick ascending limb (TAL) prompted us to investigate a possible autocrine and/or paracrine effect of this agent. The net chloride flux (JCl) has been determined in isolated cortical and medullary TALs by the in vitro microperfusion technique. 2. In both segments, endothelin 1 (ET-1) at
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7. Prostaglandin E2 abrogates endothelin-induced vasoconstriction in renal outer medullary descending vasa recta of the rat.
Endothelins (ET) and prostaglandin E2 are synthesized in the inner medulla by collecting duct epithelium and interstitial cells, respectively. All ascending vasa recta (AVR) blood returns from the inner medulla to the cortex in outer medullary vascular bundles. We reasoned that hormones might influence medullary blood flow by diffusing across AVR fenestratio
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8. Receptor-induced depletion of phosphatidylinositol 4,5-bisphosphate inhibits inwardly rectifying K+ channels in a receptor-specific manner
Phosphatidylionsitol 4,5-bisphosphate (PIP2), a substrate of phospholipase C, has recently been recognized to regulate membrane-associated proteins and act as a signal molecule in phospholipase C-linked Gq-coupled receptor (GqPCR) pathways. However, it is not known whether PIP2 depletion induced by GqPCRs can act as receptor-specific signals in native cells.
National Academy of Sciences.
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9. Endothelin ETB Receptors in Arteries and Veins: Multiple Actions in the Vein
Endothelin receptors (ETA and ETB) mediate responses to ET-1. ETB receptor function seems to differ between a similarly sized arterial and venous pair, the rat vena cava (RVC) and rat thoracic aorta (RA). ETB receptors mediate RVC contraction directly, but it is unclear whether ETB receptors mediate contraction in RA. Because of these apparent differenc
American Society for Pharmacology and Experimental Therapeutics.
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10. DNA microarray reveals changes in gene expression of shear stressed human umbilical vein endothelial cells
Using DNA microarray screening (GeneFilter 211, Research Genetics, Huntsville, AL) of mRNA from primary human umbilical vein endothelial cells (HUVEC), we identified 52 genes with significantly altered expression under shear stress [25 dynes/cm2 for 6 or 24 h (1 dyne = 10 μN), compared with matched stationary controls]; including several genes not heretofor
The National Academy of Sciences.
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11. Endothelium dependency of contractile activity differs in infant and adult vertebral arteries.
Contractions to serotonin (5-HT) and endothelin-1 (ET-1) in infant (0-2 yr) and adult (38-71 yr) vertebral arteries were examined in the presence of either the cyclooxygenase inhibitor indomethacin or NG-monomethyl-L-arginine (L-NMMA), an inhibitor of nitric oxide production. In addition, endothelium-dependent relaxations to acetylcholine were characterized
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12. Interleukin-6 attenuates agonist-mediated calcium mobilization in murine osteoblastic cells.
Interleukin-6 (IL-6) is a multifunctional cytokine which is made by osteoblasts and has diverse effects on bone metabolism. We studied the interaction of IL-6 with the Ca2+ and cAMP signaling systems in the osteoblastic cell line UMR-106 and in primary osteoblastic cultures derived from neonatal rat calvariae. IL-6 did not alter basal intracellular calcium c