Progenitors Cells
Mostrando 1-12 de 731 artigos, teses e dissertações.
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1. Macrophages: key players in erythrocyte turnover
ABSTRACT The development of red blood cells (RBCs), or erythropoiesis, occurs in specialized niches in the bone marrow, called erythroblastic islands, composed of a central macrophage surrounded by erythroblasts at different stages of differentiation. Upon anemia or hypoxemia, erythropoiesis extends to extramedullary sites, mainly spleen and liver, a process
Hematology, Transfusion and Cell Therapy. Publicado em: 2022
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2. Generation of hematopoietic stem/progenitor cells with sickle cell mutation from induced pluripotent stem cell in serum-free system
ABSTRACT Introduction Sickle cell disease (SCD) is a monogenic disease and it is estimated that 300,000 infants are born annually with it. Most treatments available are only palliative, whereas the allogeneic hematopoietic stem cell transplantation offers the only potential cure for SCD. Objective Generation of human autologous cells, when coupled with ind
Hematol., Transfus. Cell Ther.. Publicado em: 2021-06
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3. CCAAT/enhancer-binding protein alpha (CEBPA) gene haploinsufficiency does not alter hematopoiesis or induce leukemia in Lck-CALM/AF10 transgenic mice
Although rare, CALM/AF10 is a chromosomal rearrangement found in immature T-cell acute lymphoblastic leukemia (T-ALL), acute myeloid leukemia, and mixed phenotype acute leukemia of T/myeloid lineages with poor prognosis. Moreover, this translocation is detected in 50% of T-ALL patients with gamma/delta T cell receptor rearrangement, frequently associated wit
Braz J Med Biol Res. Publicado em: 27/05/2019
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4. CD47 expression is decreased in hematopoietic progenitor cells in patients with myelofibrosis
Myelofibrosis (MF) is characterized by increased circulating hematopoietic progenitor cells (HPCs), abnormal cytokine levels, and the survival advantage of neoplastic progenitors over their normal counterparts, which leads to progressive disappearance of polyclonal hematopoiesis. CD47 is a surface glycoprotein with many functions, such as acting as a phagocy
Braz J Med Biol Res. Publicado em: 10/12/2018
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5. Single-cell qPCR facilitates the optimization of hematopoietic differentiation in hPSCs/OP9 coculture system
Human pluripotent stem cells (hPSCs)/OP9 coculture system is a widely used hematopoietic differentiation approach. The limited understanding of this process leads to its low efficiency. Thus, we used single-cell qPCR to reveal the gene expression profiles of individual CD34+ cells from different stages of differentiation. According to the dynamic gene expres
Braz J Med Biol Res. Publicado em: 15/03/2018
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6. Fetal Cerebrospinal Fluid Promotes Proliferation and Neural Differentiation of Stromal Mesenchymal Stem Cells Derived from Bone Marrow
ABSTRACT Embryonic cerebrospinal fluid (E-CSF) contains many neurotrophic and growth factors, acts as a growth medium for cortical progenitors, and can modulate proliferation and differentiation of neural stem cells. Mesenchymal stem cells (MSCs) are multipotential stem cells that can differentiate into several types of mesenchymal cells as well as nonmesenc
Braz. arch. biol. technol.. Publicado em: 08/01/2018
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7. A combination of STI571 and BCR-ABL1 siRNA with overexpressed p15INK4B induced enhanced proliferation inhibition and apoptosis in chronic myeloid leukemia
p15INK4B, a cyclin-dependent kinase inhibitor, has been recognized as a tumor suppressor. Loss of or methylation of the p15INK4B gene in chronic myeloid leukemia (CML) cells enhances myeloid progenitor formation from common myeloid progenitors. Therefore, we examined the effects of overexpressed p15INK4B on proliferation and apoptosis of CML cells. Overexpre
Braz J Med Biol Res. Publicado em: 14/10/2014
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8. Isolation and characterization of mesenchymal progenitors derived from the bone marrow of goats native from northeastern Brazil
PURPOSE:To characterize bone marrow progenitors cells grown in vitro,using native goats from northeastern Brazil as animal model.METHODS:Ten northeastern Brazil native goats of both genders were used from the Piauí Federal University Agricultural Science Center's (UFPI) - Goat Farming Sector. Bone marrow aspirates where taken from the tibial ridge and seede
Acta Cir. Bras.. Publicado em: 2014-08
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9. Obesity and inflammation and the effect on the hematopoietic system
Bone marrow is organized in specialized microenvironments known as 'marrow niches'. These are important for the maintenance of stem cells and their hematopoietic progenitors whose homeostasis also depends on other cell types present in the tissue. Extrinsic factors, such as infection and inflammatory states, may affect this system by causing cytokine dysregu
Rev. Bras. Hematol. Hemoter.. Publicado em: 2014-04
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10. In vitro inhibitory effects of imatinib mesylate on stromal cells and hematopoietic progenitors from bone marrow
Imatinib mesylate (IM) is used to treat chronic myeloid leukemia (CML) because it selectively inhibits tyrosine kinase, which is a hallmark of CML oncogenesis. Recent studies have shown that IM inhibits the growth of several non-malignant hematopoietic and fibroblast cells from bone marrow (BM). The aim of the present study was to evaluate the effects of IM
Braz J Med Biol Res. Publicado em: 25/09/2012
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11. A conexina 26 e sua relação com outras proteínas no órgão de Corti / The connexin 26 and its relationship with other proteins from the organ of Corti
A causa mais frequente de surdez de herança autossômica recessiva são as mutações no lócus DFNB1, onde estão os genes GJB2 e GJB6. Dentre os indivíduos com deficiência auditiva associada a esse lócus, 10% a 50% apresentam uma única mutação recessiva no gene GJB2, frequência muito superior à esperada em função da frequência de heterozigotos
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 04/11/2011
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12. Isolamento de uma subpopulação de células de melanoma murino com características de progenitoras tumorais e análises de suas propriedades tronculares e tumorigênicas / Isolation of the subpopulation of melanoma cells with characteristics progenitors cells and analysis of their properties stems and tumorigenics
O melanoma é o câncer de pele existente mais agressivo e sua resistência para muitas modalidades terapêuticas é conhecida. É plausível a conjectura de que a resistência deste tumor esteja intimamente relacionada à presença de uma subpopulação de células progenitoras tumorais. Com base nesta informação nosso trabalho propôs isolar células de
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 26/01/2011