Primidone
Mostrando 1-12 de 16 artigos, teses e dissertações.
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1. Primidona : importância das propriedades físico-químicas na análise qualitativa e quantitativa. Revisão comentada / Primidone:importance of physico-chemical properties in qualitative and quantitative analisys
Alguns métodos qualitativos e quantitativos de análise de primidona foram revisados e comentados com base nas propriedades físico-químicas do fármaco. Métodos cromatográficos e imunoenzimáticos são bastante empregados na análise do fármaco em fluidos biológicos e na monitorização clínica do mesmo. A determinação por volumetria de neutraliza�
Publicado em: 2010
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2. Metalloporphyrins and salen complexes as a P450 biomimetic model for the metabolism of antiepileptic and antidepressant drugs / Metaloporfirinas e compostos salen como modelos biomiméticos do citocromo P450 no metabolismo de fármacos anticonvulsivante e antidepressivo
In this work, the catalytic activities of metalloporphyrins and the salen complex (Jacobsen catalyst) in solution and immobilized on different supports were studied in the oxidation of hydrocarbons, anticonvulsivant drugs (carbamazepine and primidone) and antidepressives (fluoxetine) by the following oxygen donors: hydrogen peroxide, terc-butyl hydroperoxide
Publicado em: 2008
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3. The effects of phenytoin on phenobarbitone and primidone metabolism.
Serum concentrations of primidone and its metabolites-phenobarbitone and phenylethylmalonamide-were measured in 40 epileptic patients receiving treatment with primidone alone or primidone plus phenytoin. Serum phenobarbitone concentrations were also measured in 100 patients receiving phenobarbitone, alone or with phenytoin showed raised serum phenobarbitone
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4. Primidone in essential tremor of the hands and head: a double blind controlled clinical study.
Uncontrolled clinical studies have suggested that primidone may be effective in reducing essential tremor thus providing a valuable alternative to beta-adrenoreceptor antagonists which are currently the drugs of first choice. A double blind, placebo controlled trial of primidone in essential tremor of the hands and head was carried out using both clinical an
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5. A comparison of primidone, propranolol, and placebo in essential tremor, using quantitative analysis.
The effects of placebo, propranolol and primidone were compared in 14 patients with essential tremor in a double blind, randomised, crossover study. Objective measures of tremor were obtained using an accelerometer with subsequent spectral analysis. Both propranolol (p less than 0.01) and primidone (p less than 0.01) gave significant improvement in tremor, b
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6. Essential tremor: response to primidone.
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7. Acute diphenylhydantoin and primidone poisoning treated by peritoneal dialysis.
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8. Two antiepileptic drugs for intractable epilepsy with complex-partial seizures.
The value of adding a second antiepileptic drug in intractable epilepsy with complex-partial seizures was studied in a long-term prospective trial in 30 adult patients who failed to respond to the maximum use of carbamazepine, phenytoin, phenobarbital or primidone as the first drug. Based on the individual previous history of one-drug treatment, the most pro
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9. Anticonvulsant-induced dyskinesias: a comparison with dyskinesias induced by neuroleptics.
Anticonvulsants cause dyskinesias more commonly than has been appreciated. Diphenylhydantoin (DPH), carbamazepine, primidone, and phenobarbitone may cause asterixis. DPH, but not other anticonvulsants, may cause orofacial dyskinesias, limb chorea, and dystonia in intoxicated patients. These dyskinesias are similar to those caused by neuroleptic drugs and may
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10. Genetic essential tremor in γ-aminobutyric acidA receptor α1 subunit knockout mice
Essential tremor is the most common movement disorder and has an unknown etiology. Here we report that γ-aminobutyric acidA (GABAA) receptor α1–/– mice exhibit postural and kinetic tremor and motor incoordination that is characteristic of essential tremor disease. We tested mice with essential-like tremor using current drug therapies that alleviate sym
American Society for Clinical Investigation.
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11. The Association Between Antiepileptic Drugs and Bone Disease
A growing body of literature indicates an association between antiepileptic drugs (AEDs) and bone disease, including histologic, radiographic, and biochemical evidence. The AEDs most commonly reported to cause decreased bone mineral density and disorders of bone metabolism are inducers of the cytochrome P450 enzyme system (phenobarbital, phenytoin, carbamaze
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12. Phenylethylmalonamide in essential tremor. A double-blind controlled study.
A randomised double-blind placebo-controlled trial of phenylethylmalonamide, the major metabolite of primidone was performed in eight patients with essential tremor. Phenylethylmalonamide was given in a daily dose of 400 mg for one week and 800 mg for a second week. The compound had no statistically significant effect on the amplitude of tremor assessed by a