Polyketide Synthases
Mostrando 1-12 de 53 artigos, teses e dissertações.
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1. Biosynthetic Insights into p-Hydroxybenzoic Acid-Derived Benzopyrans in Piper gaudichaudianum
Piper gaudichaudianum Kunth (Piperaceae) accumulates gaudichaudianic acid, a prenylated benzopyran, as its major component. Interestingly, this trypanocidal compound occurs as a racemic mixture. Herein, transcriptomic investigations of Piper gaudichaudianum using the RNA-seq approach are reported, and from the analysis of the transcripts expressed it was pos
J. Braz. Chem. Soc.. Publicado em: 2018-05
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2. TRIAGEM METABÓLICA POR PKS E NRPS EM ACTINOBACTÉRIAS ENDOFÍTICAS DE Citrus reticulata
Polyketides and non-ribosomal peptides are natural products widely found in bacteria, fungi and plants. The biological activities associated with these metabolites have attracted special attention in biopharmaceutical studies. Polyketide synthases act similarly to fatty acids synthetases and the whole multi-enzymatic set coordinating precursor and extending
Quím. Nova. Publicado em: 2015-03
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3. Diversidade e atividade antimicrobiana de bactérias isoladas de esponjas marinhas / Diversity and antimicrobial activity of bacteria isolated from marine sponges
Nas últimas décadas um grande número de compostos de interesse biotecnológico, como por exemplo, citotoxinas, agentes antifúngicos, antimicrobianos, antivirais e anticancerígenos têm sido isolados de esponjas marinhas. Entretanto, estudos comprovam que, em muitos casos, os compostos ativos desses animais são oriundos de micro-organismos associados, q
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 04/05/2011
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4. In silicio expression analysis of PKS genes isolated from Cannabis sativa L.
Cannabinoids, flavonoids, and stilbenoids have been identified in the annual dioecious plant Cannabis sativa L. Of these, the cannabinoids are the best known group of this plant's natural products. Polyketide synthases (PKSs) are responsible for the biosynthesis of diverse secondary metabolites, including flavonoids and stilbenoids. Biosynthetically, the can
Genetics and Molecular Biology. Publicado em: 29/10/2010
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5. Unusual intron in the second exon of a Type III polyketide synthase gene of Alpinia calcarata Rosc.
Plant phenolic compounds form a valuable resource of secondary metabolites having a broad spectrum of biological activities. Type III polyketide synthases play a key role in the formation of basic structural skeleton of the phenolic compounds. As a group of medicinal plants, PKSs with novel features are expected in the genome of Zingiberaceae. The genomic ex
Genetics and Molecular Biology. Publicado em: 2010
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6. Polyketide biosynthetic gene bioprospection in metagenomic DNA from Atlantic Forest soil. / Bioprospecção de genes biossintéticos de policetídeos em DNA metagenômico de solo de Mata Atlântica.
The Brazilian Atlantic Forest is considered as one of the most important reservoir of biodiversity in the planet. This biome is extremely important for its richness of plant and animal species but although with their composition and interactions poorly known and unexplored from a microbiological perspective. One gram of soil can contain near 10 billion micro
Publicado em: 2009
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7. SEARCHPKS: a program for detection and analysis of polyketide synthase domains
SEARCHPKS is a software for detection and analysis of polyketide synthase (PKS) domains in a polypeptide sequence. Modular polyketide synthases are unusually large multi-enzymatic multi-domain megasynthases, which are involved in the biosynthesis of pharmaceutically important natural products using an assembly-line mechanism. This program facilitates easy id
Oxford University Press.
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8. Genetic construction and functional analysis of hybrid polyketide synthases containing heterologous acyl carrier proteins.
The gene that encodes the acyl carrier protein (ACP) of the actinorhodin polyketide synthase (PKS) of Streptomyces coelicolor A3(2) was replaced with homologs from the granaticin, oxytetracycline, tetracenomycin, and putative frenolicin polyketide synthase gene clusters. All of the replacements led to expression of functional synthases, and the recombinants
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9. Microbial polyketide synthases: More and more prolific
The National Academy of Sciences.
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10. Polyketide and non-ribosomal peptide synthases: Falling together by coming apart
The National Academy of Sciences.
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11. Emergent gene order in a model of modular polyketide synthases
Polyketides are a class of biologically active heteropolymers produced by assembly line-like multiprotein complexes of modular polyketide synthases (PKS). The polyketide product is encoded in the order of the PKS proteins in the assembly line, suggesting that polyketide diversity derives from combinatorial rearrangement of these PKS complexes. Remarkably, th
National Academy of Sciences.
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12. Aspergillus has distinct fatty acid synthases for primary and secondary metabolism
Aspergillus nidulans contains two functionally distinct fatty acid synthases (FASs): one required for primary fatty acid metabolism (FAS) and the other required for secondary metabolism (sFAS). FAS mutants require long-chain fatty acids for growth, whereas sFAS mutants grow normally but cannot synthesize sterigmatocystin (ST), a carcinogenic secondary m
The National Academy of Sciences of the USA.