Poloxamer
Mostrando 1-12 de 46 artigos, teses e dissertações.
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1. Nanostructured polymeric system based of cashew gum for oral admnistration of insulin
ABSTRACT The subcutaneous administration of insulin has been the treatment of millions of diabetics in the world. However, for such via insulin is invasive and not mimics the physiological action causing side effects. The oral route would be the most physiological and comfortable option, but the oral bioavailability of insulin is low by proteolytic activity
Matéria (Rio J.). Publicado em: 16/09/2019
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2. The efficacy of sustained-release chitosan microspheres containing recombinant human parathyroid hormone on MRONJ
Abstract Treatment of patients with bisphosphonate usage is a significant concern for oral surgeons because it interferes with jaw bone turnover and regeneration. In case of adverse effects manifesting related to bisphosphonate use, oral surgeons are usually treating and keep the patient’s symptoms under control. In this study, we aimed to investigate a ne
Braz. oral res.. Publicado em: 29/08/2019
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3. Preparation and characterization of cefuroxime axetil solid dispersions using poloxamer 188
The main objective of the present work was to enhance the solubility and dissolution rate of poorly water-soluble drug cefuroxime axetil (CA) by formulating it into solid dispersions (SDs) with water soluble carrier poloxamer 188. Different methods were employed to prepare the dispersion, such as: Solvent method (SM), Kneading method (KM), Melt evaporation m
Braz. J. Pharm. Sci.. Publicado em: 08/04/2019
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4. Process Evaluation of Sugar-Based Polymeric Colloidal Nanocarrier Formation
Abstract Several studies have demonstrated that sugar-based nanocarriers are recommended to develop drug delivery systems since they are biocompatible and biodegradable and might improve the therapeutic index of currently used drugs by reducing their toxicity and enhancing their bioavailability. Therewith, this work studied the processing conditions to forma
Mat. Res.. Publicado em: 31/01/2019
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5. Preparation and physicochemical characterization of meloxicam orally fast disintegration tablet using its solid dispersion
ABSTRACT Meloxicam (MLX) is a non-steroidal, anti-inflammatory drug that is prescribed in the treatment of rheumatoid arthritis and osteoarthritis. MLX is practically insoluble in water and exhibits a slow onset of action. In this study, MLX solid dispersions (MLX SDs) were prepared to improve the water solubility of this poorly water-soluble drug. Then oral
Braz. J. Pharm. Sci.. Publicado em: 05/03/2018
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6. Development and validation of an analytical method using High Performance Liquid Chromatography (HPLC) to determine ethyl butylacetylaminopropionate in topical repellent formulations
ABSTRACT Diseases caused by insects are frequent in poor countries, leading to epidemic scenarios in urban areas; e.g., Dengue, Zika and Chikungunya. For this reason, the development of a safe and efficient topical formulation is essential. Ethyl butylacetylaminopropionate (EB) is a mosquito repellent developed by Merck, which is used in products for adults,
Braz. J. Pharm. Sci.. Publicado em: 22/06/2017
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7. Liposomes as potential carriers for ketorolac ophthalmic delivery: formulation and stability issues
ABSTRACT Drug delivery to treat ocular disorders locally is a challenging endeavor. Traditional ocular dosage form - eye drops - exhibits poor availability, consequently inefficient therapeutic response. The objective of the study was to formulate and characterize a ketorolac tromethamine ocular system with a prolonged release pattern based on liposomes as a
Braz. J. Pharm. Sci.. Publicado em: 22/06/2017
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8. Preparation, characterization and evaluation of the in vivo trypanocidal activity of ursolic acid-loaded solid dispersion with poloxamer 407 and sodium caprate
O ácido ursólico é um candidato promissor para o tratamento da doença de Chagas, contudo este fármaco possui baixa solubilidade aquosa e limitada absorção intestinal, ambos os fatores limitantes da biodisponibilidade. Entre as estratégias para potencializar a solubilidade e a dissolução de fármacos lipofílicos, as dispersões sólidas estão cres
Braz. J. Pharm. Sci.. Publicado em: 2015-03
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9. Physico-chemical properties of meso-tetrakis(p-methoxyphenyl)porphyrin (TMPP) incorporated into pluronicTM p-123 and f-127 polymeric micelles
The physicochemical properties (solubilization, structural organization and stability) of meso-tetrakis(p-methoxyphenyl)porphyrin (TMPP), a promising photosensitizer for photodynamic therapy, solubilized in polymeric micelles of tri-block copolymers PluronicTM P-123 and F-127, were studied. The formulations obtained by the solid dispersion method led to mono
Quím. Nova. Publicado em: 2014
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10. Formulation and characterization of poloxamer 407®: thermoreversible gel containing polymeric microparticles and hyaluronic acid
The influence of the composition and preparation method on the sol-gel transition temperature (Tsol-gel) and rheological response of poloxamer-based formulations was determined. Manual and more complex mechanical stirring were found to provide similar results. In addition, a linear dependence of Tsol-gel on the poloxamer content was observed in the range of
Quím. Nova. Publicado em: 2013
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11. Dispersões sólidas de ácido ursólico para otimização do tratamento da doença de Chagas / Solid dispersions containing ursolic acid for the treatment optimization of Chagas disease
A doença de Chagas representa um grave problema de saúde pública, afetando principalmente a população de baixa renda, o que a torna negligenciada pela indústria farmacêutica. Atualmente, existe apenas um fármaco disponível para o tratamento, o benzonidazol, porém este apresenta eficácia limitada e está associado a diversos efeitos colaterais. O �
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 29/06/2012
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12. Preparation of piroxicam microparticulated solid dispersions by spray congealing / Obtenção de dispersões sólidas microparticuladas de piroxicam por spray congealing
O piroxicam (PRX) e um antiinflamatorio nao esteroidal com propriedades analgesicas, antiinflamatorias e antipireticas pertencente a classe II do SCB. Farmacos desta classe apresentam como etapa limitante da sua absorcao a sua dissolucao, uma vez que possuem baixa solubilidade e alta permeabilidade. Assim, o aumento da solubilidade e da taxa de dissolucao do
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 02/03/2012