Podocyte
Mostrando 1-12 de 53 artigos, teses e dissertações.
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1. A rare case of PLA2R- and THSD7A-positive idiopathic membranous nephropathy
RESUMO A Nefropatia Membranosa Idiopática (NMi) é uma frequente causa de síndrome nefrótica em adultos e sua etiologia pode ser estratificada em primária/idiopática ou secundária. O conhecimento da fisiopatologia da NMi sugeriu a presença de autoanticorpos (PLA2R e a THSD7A) direcionados contra antígenos existentes nos podócitos. A detecção de an
J. Bras. Nefrol.. Publicado em: 28/10/2019
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2. Focal and Segmental Glomerulosclerosis and Membranous Nephropathy overlapping in a patient with Nephrotic Syndrome: a case report
Resumo Introdução: Alguns casos de nefropatia membranosa (NM) apresentam glomeruloesclerose segmentar e focal (GESF) tipicamente associada a progressão da doença. Contudo, relatamos o caso de uma paciente que parece ter NM e GESF, ambas primárias. Apresentação do caso: Uma jovem branca de 17 anos de idade com edema de membros inferiores associado a
J. Bras. Nefrol.. Publicado em: 25/02/2019
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3. Does prolonged pneumoperitoneum affect the kidney? Oxidative stress, stereological and electron microscopy study in a rat model
Purpose:Pneumoperitoneum (Pp) at 12 to 15 mmHg in rats is associated with kidney damage. However, Pp at 8 mmHg is now known to best correlate to working pressures used in humans. Thus the aim of this work was to study the kidney of rats submitted to prolonged Pp at 8 mmHg.Materials and Methods:Rats were divided into a Sham group (n = 14), submitted to anesth
Int. braz j urol.. Publicado em: 2013-01
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4. Expressão gênica de moléculas associadas ao podócito em pacientes portadores de glomerulopatias proteinúricas
Introdução: A injúria ao podócito glomerular tem um papel crítico para o surgimento de proteinúria em diferentes glomerulopatias. Neste estudo avaliamos a expressão gênica das proteínas associadas ao podócito em biópsias renais e na urina simultaneamente em pacientes com glomerulopatias proliferativas (GPP) e não proliferativas (GPNP) proteinúri
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 2012
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5. Maternal undernutrition and the offspring kidney: from fetal to adult life
Maternal dietary protein restriction during pregnancy is associated with low fetal birth weight and leads to renal morphological and physiological changes. Different mechanisms can contribute to this phenotype: exposure to fetal glucocorticoid, alterations in the components of the renin-angiotensin system, apoptosis, and DNA methylation. A low-protein diet d
Brazilian Journal of Medical and Biological Research. Publicado em: 2010-11
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6. Urine Podocyte mRNAs Mark Progression of Renal Disease
Because loss of podocytes associates with glomerulosclerosis, monitoring podocyte loss by measuring podocyte products in urine may be clinically useful. To determine whether a single episode of podocyte injury would cause persistent podocyte loss, we induced limited podocyte depletion using a diphtheria toxin receptor (hDTR) transgenic rat. We monitored podo
American Society of Nephrology.
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7. Distinct Roles for Basal and Induced COX-2 in Podocyte Injury
Transgenic mice that overexpress cyclooxygenase-2 (COX-2) selectively in podocytes are more susceptible to glomerular injury by adriamycin and puromycin (PAN). To investigate the potential roles of COX-2 metabolites, we studied mice with selective deletion of prostanoid receptors and generated conditionally immortalized podocyte lines from mice with either C
American Society of Nephrology.
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8. Wnt/β-Catenin Signaling Promotes Podocyte Dysfunction and Albuminuria
Podocyte dysfunction, one of the major causes of proteinuria, leads to glomerulosclerosis and end stage renal disease, but its underlying mechanism remains poorly understood. Here we show that Wnt/β-catenin signaling plays a critical role in podocyte injury and proteinuria. Treatment with adriamycin induced Wnt and activated β-catenin in mouse podocytes. O
American Society of Nephrology.
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9. BMP Signaling and Podocyte Markers Are Decreased in Human Diabetic Nephropathy in Association With CTGF Overexpression
Diabetic nephropathy is characterized by decreased expression of bone morphogenetic protein-7 (BMP-7) and decreased podocyte number and differentiation. Extracellular antagonists such as connective tissue growth factor (CTGF; CCN-2) and sclerostin domain-containing-1 (SOSTDC1; USAG-1) are important determinants of BMP signaling activity in glomeruli. We stud
Histochemical Society.
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10. Altered podocyte structure in GLEPP1 (Ptpro)-deficient mice associated with hypertension and low glomerular filtration rate
Glomerular epithelial protein 1 (GLEPP1) is a receptor tyrosine phosphatase present on the apical cell surface of the glomerular podocyte. The GLEPP1 gene (Ptpro) was disrupted at an exon coding for the NH2-terminal region by gene targeting in embryonic stem cells. Heterozygote mating produced the expected genotypic ratio of 1:2:1, indicating that the Ptpro�
American Society for Clinical Investigation.
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11. Mineralocorticoid receptor antagonism attenuates glomerular filtration barrier remodeling in the transgenic Ren2 rat
Recent evidence suggests that mineralocorticoid receptor (MR) antagonism has beneficial effects on tissue oxidative stress and insulin metabolic signaling as well as reducing proteinuria. However, the mechanisms by which MR antagonism corrects both renin-angiotensin-aldosterone system (RAAS) impairments in renal insulin metabolic signaling and filtration bar
American Physiological Society.
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12. Transcriptional induction of slit diaphragm genes by Lmx1b is required in podocyte differentiation
LMX1B encodes a LIM-homeodomain transcription factor. Mutations in LMX1B cause nail-patella syndrome (NPS), an autosomal dominant disease with skeletal abnormalities, nail hypoplasia, and nephropathy. Expression of glomerular basement membrane (GBM) collagens is reduced in Lmx1b–/– mice, suggesting one basis for NPS nephropathy. Here, we show that Lmx1b�
American Society for Clinical Investigation.