Pneumocystis Carinii
Mostrando 25-36 de 568 artigos, teses e dissertações.
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25. Ciência e Saúde na Terra dos Bandeirantes: a trajetória do Instituto Pasteur de São Paulo no período de 1903-1916
Fundamental contribuição para a história da ciência e das instituições biomédicas no Brasil - apresenta ao leitor cientistas que marcaram época como, por exemplo, o pesquisador Antonio Carini, a quem se deve a descoberta de um parasita causador da pneumonia, denominado Pneumocystis carinii, bastante citado como um microorganismo 'oportunista' em portadores de HIV. O autor constrói seu objeto a partir de fontes praticamente inexploradas: os arquivos do Instituto Pasteur paulista. Além disso, partindo do objeto empírico, talentosamente formula uma interpretação sedutora e convincente, ao discutir questões de sua pesquisa com base em competentes coleta de dados e manipulação de conceitos.
Autor(es): Teixeira, Luiz Antonio
Editora FIOCRUZ. Publicado em: 1995
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26. Population Structure of Rat-Derived Pneumocystis carinii in Danish Wild Rats
The rat model of Pneumocystis carinii pneumonia is frequently used to study human P. carinii infection, but there are many differences between the rat and human infections. We studied naturally acquired P. carinii in wild rats to examine the relevance of the rat model for human infection. P. carinii DNA was detected in 47 of 51 wild rats and in 10 of 12 noni
American Society for Microbiology.
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27. Widespread Occurrence of Pneumocystis carinii in Commercial Rat Colonies Detected Using Targeted PCR and Oral Swabs
The genus Pneumocystis contains a family of fungal organisms that infect a wide variety of mammalian species. Although it is a cause of pneumonia in immunocompromised hosts, recent evidence suggests that these organisms colonize nonimmunosuppressed hosts. Detection of cryptic colonization with Pneumocystis becomes important in animal studies when infection-f
American Society for Microbiology.
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28. Pneumocystis carinii f. sp. hominis Is Not Infectious for SCID mice
The infectious power of Pneumocystis carinii f. sp. hominis was explored by inoculating SCID mice intranasally with either P. carinii f. sp. hominis or P. carinii f. sp. muris isolates. Only mice inoculated with mouse parasites developed Pneumocystis pneumonia, as assessed by microscopy and PCR. These results suggest that humans do not contract pneumocystosi
American Society for Microbiology.
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29. Detection of Pneumocystis carinii DNA in blood by PCR is not of value for diagnosis of P. carinii pneumonia.
A nested PCR which amplified a portion of the mitochondrial large-subunit rRNA gene of Pneumocystis carinii was used to detect P. carinii DNA in blood from patients with P. carinii pneumonia. P. carinii DNA was not detected in serum and was detected at low levels of blood cells.
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30. New rat model of Pneumocystis carinii infection.
Rats free of latent Pneumocystis carinii organisms were immunosuppressed with adrenal corticosteroids and transtracheally injected with P. carinii. These animals subsequently developed P. carinii pneumonia. Infection was accomplished by using organisms from infected rat lung or from culture. Diffuse infection was produced with no significant differences in t
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31. Exacerbation of Pneumocystis carinii pneumonia in immunodeficient (scid) mice by concurrent infection with a pneumovirus.
scid mice naturally infected with Pneumocystis carinii and inoculated with a normally apathogenic pneumovirus had significantly higher P. carinii cyst counts and developed significantly more severe P. carinii-related disease than did sham-inoculated, P. carinii-infected scid mice. P. carinii-free, virus-infected scid mice survived for 2 months despite high p
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32. Identification of Pneumocystis carinii chromosomes and mapping of five genes.
Pulsed field gel electrophoresis was used to identify the chromosome-size DNA of Pneumocystis carinii, a major pathogen of immunocompromised patients. Thirteen chromosomes of rodent Pneumocystis carinii, ranging in size from 300 to 700 kilobases (kb), were identified. The minimum genome size for P. carinii, estimated on the basis of the sizes of chromosomes,
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33. Antigenic differences associated with genetically distinct Pneumocystis carinii from rats.
Pneumocystis carinii is a family of organisms found in a wide variety of mammalian lungs. In immunocompromised hosts, the organisms are able to produce an oftentimes fatal pneumonia. The existence of distinct types of Pneumocystis populations is strongly supported by antigenic and genetic evidence. In the present study, we assessed the antigenic profiles of
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34. Probable Mother-to-Infant Transmission of Pneumocystis carinii f. sp. hominis Infection
A mother and her 4.5-week-old infant had Pneumocystis carinii pneumonia contemporaneously. Genotyping of P. carinii f. sp. hominis DNA at three independent loci showed the same genotype in samples from mother and infant. These data suggest transmission of P. carinii organisms from the mother to her infant.
American Society for Microbiology.
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35. Attachment of Pneumocystis carinii to Type I Alveolar Cells Studied by Freeze-Fracture Electron Microscopy
Pneumocystis carinii was tightly attached to host alveolar type I cells, as judged by freeze-fracture electron microscopy. In contrast to other organisms studied by this technique, no changes in the cell membranes of P. carinii or the host cells could be demonstrated. These data suggest that P. carinii attaches in an unusual manner.
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36. DNA sequences identical to Pneumocystis carinii f. sp. carinii and Pneumocystis carinii f. sp. hominis in samples of air spora.
Samples of ambient air collected with three different types of spore traps in a rural location were examined for the presence of Pneumocystis carinii by screening for P. carinii-specific DNA sequences by DNA amplification. Eleven spore trap samples were analyzed by nested PCR, using oligonucleotide primers designed for the gene encoding the mitochondrial lar