Plga Peg
Mostrando 1-9 de 9 artigos, teses e dissertações.
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1. Preparation and physicochemical characterization of prazosin conjugated PLGA nanoparticles for drug delivery of flutamide
In the current work, a sustained drug delivery system of flutamide (FLT) was developed using Poly(D,L-lactide-co-glycolide) (PLGA) decorated bypoly(ethylene glycol) (PEG) grafted prazosin (PLGA-PEG-Praz) as a targeting moiety. In a multi-step reaction, PLGA was linked to PEG and prazosin. The structure of the synthesized polymers was confirmed by FTIR and 1H
Braz. J. Pharm. Sci.. Publicado em: 08/04/2019
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2. Influence of PLGA and PLGA-PEG on the dissolution profile of oxaliplatin
Abstract Oxaliplatin was inserted into polymeric matrices aiming to study the interaction of this drug with these polymers and its capability to diffuse to the environment. Tested polymers were: (1) polyethylene glycol (PEG), (2) poly(lactic-co-glycolic acid) (PLGA), and (3) a copolymer of them (PLGA-PEG). The latter two were synthesized by us using polycond
Polímeros. Publicado em: 07/06/2016
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3. DESENVOLVIMENTO E AVALIAÇÃO FARMACOCINÉTICA DE NANOPARTÍCULAS DE PLGA E PLGA-PEG CONTENDO CURCUMINA
As nanopartículas poliméricas apresentam grande importância na área farmacêutica em virtude de serem sistemas coloidais que possuem interessantes propriedades físicoquímicas, tais como o tamanho reduzido, a ampla área superficial, carga superficial, que as tornam eficientes sistemas para aplicação na liberação controlada de fármacos. A curcumina
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 14/12/2011
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4. Citotoxicidade e atividade antitumoral do Ãcido Ãsnico de Cladonia Substelllata encapsulado em microesferas de copolÃmero de Ãcido lÃctico e glÃcolico (PLGA)
Na tecnologia de sistemas de liberaÃÃo controlada, a microencapsulaÃÃo de fÃrmacos envolve processos complexos que permitem incorporar, a um princÃpio ativo, novas propriedades funcionais e âinteligentesâ, como a liberaÃÃo controlada em um meio especific o ou sob condiÃÃes apropriadas, tornando o produto final mais eficaz e menos tÃxico. PoliÃs
Publicado em: 2003
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5. γ-irradiation of PEGd,lPLA and PEG-PLGA Multiblock Copolymers: II. Effect of Oxygen and EPR Investigation
The purpose of this research was to evaluate how the presence of oxygen can affect irradiation-induced degradation reactions of PEGd,lPLA and PEG-PLGA multiblock copolymers submitted to gamma irradiation and to investigate the radiolytic behavior of the polymers. PEGd,lPLA, PEG-PLGA, PLA, and PLGA were irradiated by using a 60Co irradiation source in air and
Springer US.
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6. Effect of additives on the release of a model protein from PLGA microspheres
The purpose of this study was to investigate the effect of 2 additives, poly(ethylene glycol (PEG) 1000 and 1,2,3-tridecanoyl glycerol (tricaprin), on the physico-chemical characteristics and in vitro release of a model protein, bovine serum albumin (BSA), form poly(D,L-lactic-co-glycolic acid) (PLGA) microspheres. BSA-loaded microspheres were prepared by th
Springer-Verlag.
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7. Biodegradable microspheres as carriers for native superoxide dismutase and catalase delivery
The purpose of this research was to encapsulate superoxide dismutase (SOD) and catalase (CAT) in biodegradable microspheres (MS) to obtain suitable sustained protein delivery. A modified water/oil/water double emulsion method was used for poly(D,L-lactide-co-glycolide) (PLGA) and poly(D,L-lactide) PLA MS preparation co-encapsulating mannitol, trehalose, and
Springer-Verlag.
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8. Biodegradable polymer nanoparticles that rapidly penetrate the human mucus barrier
Protective mucus coatings typically trap and rapidly remove foreign particles from the eyes, gastrointestinal tract, airways, nasopharynx, and female reproductive tract, thereby strongly limiting opportunities for controlled drug delivery at mucosal surfaces. No synthetic drug delivery system composed of biodegradable polymers has been shown to penetrate hig
National Academy of Sciences.
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9. Drug Transport to Brain with Targeted Nanoparticles
Summary: Nanoparticle drug carriers consist of solid biodegradable particles in size ranging from 10 to 1000 nm (50–300 nm generally). They cannot freely diffuse through the blood-brain barrier (BBB) and require receptor-mediated transport through brain capillary endothelium to deliver their content into the brain parenchyma. Polysorbate 80-coated polybuty
The American Society for Experimental NeuroTherapeutics.