Platinum Ii Complexes
Mostrando 1-12 de 42 artigos, teses e dissertações.
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1. COMPLEXOS DE PLATINA(II) CONJUGADO E ANÁLOGO A O-GLICOSÍDEOS: SÍNTESE, CARACTERIZAÇÃO ESTRUTURAL E ATIVIDADE ANTITUMORAL
The synthesis, characterization, cytotoxicity and antitumor activity of platinum(II) complexes coordinated to O-glycoside and analogous is reported. Through the acute toxicity tests, it was possible to fit the complexes into categories according to the OECD protocol. The cis-[PtCl2(C6H14S2O2)-κ2S] complex was classified in category 3 and the cis-[PtCl2(C26H
Quím. Nova. Publicado em: 2020-06
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2. Studies of the Colloidal Properties of Superparamagnetic Iron Oxide Nanoparticles Functionalized with Platinum Complexes in Aqueous and PBS Buffer Media
This work has focused on the synthesis of three nanosystems composed of superparamagnetic iron oxide nanoparticles (SPIONs) coated either with a carboxylate platinum(IV) complex (PD = cis,cis,trans-[Pt(NH3)2Cl2(HOOCCH2CH2COO)(OH)]) or with platinum(II) complex functionalized dextrans (DexPt1 = [Pt(Dex-NH2)Cl3] and DexPt2 = [Pt(Dex-NH2)(NH3)2(H2O)]). All nano
J. Braz. Chem. Soc.. Publicado em: 2017-05
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3. Synthesis and evaluation of platinum complexes with potential antitumor activity
Abstract A novel series of platinum (II) complexes was synthesized and the complexes were evaluated for their in vitro cytotoxicity against four human cancer cells lines. Five platinum complexes showed activity against at least one tumor cell line. Complexes 3 and 6 were promising, being active, at micromolar concentrations, against all the assayed tumor cel
Braz. J. Pharm. Sci.. Publicado em: 20/04/2017
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4. Novel 3-(aminomethyl)naphthoquinone mannich base-platinum(IV) complexes: synthesis, characterization, electrochemical and cytotoxic studies
Três novos complexos de platina(IV), cis,cis,trans-[Pt(HL1-3)Cl2(OH)2] 1b-3b (HL = 2-hidroxi3-[(R¹-amino)(piridin-2-il)metil]-1,4-naftoquinona, R¹ = n-butil, HL1; n-heptil, HL2 and n-decil, HL3) foram obtidos através da oxidação dos respectivos precursores cis-[Pt(HL1-3)Cl2] 1a-3a. Estudos de voltametria cíclica de 1b-3b em MeCN mostraram o processo r
J. Braz. Chem. Soc.. Publicado em: 2013-04
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5. Descriptores globales y locales de la reactividad para el diseño de nuevos fármacos anticancerosos basados en cis-platino(II)
Density functional theory was used to investigate the global and local reactivity of some cis-platinum(II) complexes including anticancer drugs, such as cisplatin and carboplatin. Calculated equilibrium geometries at mPW1PW/LANL2DZ* are in close agreement with their available X-ray data. We develop three new local reactivity descriptors: atomic descriptor of
Quím. Nova. Publicado em: 2013
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6. SYNTHESIS AND CHARACTERIZATION OF BINUCLEATING LIGANDS DERIVED FROM THE ISONIAZID AND THEIR DINUCLEAR COPPER(II) COMPLEXES / SÍNTESE E CARACTERIZAÇÃO DE LIGANTES BINUCLEANTES DERIVADOS DA ISONIAZIDA E SEUS COMPLEXOS BINUCLEARES DE COBRE (II)
Considering the limitations and undesirable side effects observed in cancer therapy with platinum derivatives, many efforts have been made with the aim of obtaining new drugs more effective and less toxic, able to promote the hydrolytic cleavage or oxidative DNA chain other subcellular structures critical. Until now, some copper complexes have been developed
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 23/02/2011
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7. COMPLEXOS MONO E DINUCLEARES DE PLATINA(II) COM LIGANTES AMINADOS N-ALQUILADOS DE CADEIA LONGA: SÍNTESE, CARACTERIZAÇÃO E INCORPORAÇÃO EM LIPOSSOMAS
O câncer, atualmente, é considerado um problema de saúde pública, sendo responsável por cerca de 12% de todas as causas de óbito no mundo. O tratamento desta doença pode ser realizado através da quimioterapia, uma alternativa muito importante. Desde a descoberta da atividade antitumoral da cisplatina, a investigação a respeito do uso de complexos m
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 10/12/2010
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8. SÍNTESE E CARACTERIZAÇÃO DE COMPLEXOS DE PLATINA COM LIGANTES DIAMINADOS N-ALQUILADOS DE CADEIA LONGA CONTENDO UM GRUPO HIDROXILA
Cancer is considered one of the main causes of death around the world. This disease can be treated using radiotherapy, surgery, and chemotherapy. Since the discovery of the anticancer activity of cisplatin, studies involving the use of metal complexes as drugs have grown substantially. Aiming to improve the spectrum of antitumor activity, to decrease side ef
Publicado em: 2010
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9. Novel platinum(II) complexes of long chain aliphatic diamine ligands with oxalato as the leaving group: comparative cytotoxic activity relative to chloride precursors
Os complexos de platina são importantes no desenvolvimento de drogas anticancerígenas. Sua citotoxicidade pode ser afetada pelos ligantes abandonadores, devido ao mecanismo da reação de hidrólise que ocorre antes da ligação do complexo ao DNA. Os grupos não-abandonadores, como as diaminas lipofílicas, também podem afetar a velocidade de entrada do
Journal of the Brazilian Chemical Society. Publicado em: 2010
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10. Liposome encapsulation of lipophilic N-alkyl-propanediamine platinum complexes: impact on their cytotoxic activity and influence of the carbon chain length
Complexos de platina(II) derivados de N-alquil-propanodiamina com cadeia carbônica variável (C8, C10, C12 ou C14) foram incorporados em lipossomas e a atividade citotóxica dessas formulações foi avaliada em linhagens tumorais (A549, MDA-MB-231, B16-F1 and B16-F10) e não-tumorais (BHK-21 and CHO). Suspensões de lipossomas estáveis e monodispersas inco
Journal of the Brazilian Chemical Society. Publicado em: 2010
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11. Síntese e caracterização de um novo complexo de platina (IV) a partir de seu análogo de platina (II) utilizando iodo molecular como agente oxidante: uma rota sintética interessante para obtenção de novos complexos de platina
In an attempt to reduce toxicity and widen the spectrum of activity of cisplatin and its analogues, much attention has been focused on designing new platinum complexes. This work reports the synthesis and characterization of novel compounds of the platinum (II) and platinum (IV) containing 2-furoic hydrazide acid and iodide as ligands. Although the prepared
Química Nova. Publicado em: 2007-02
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12. Synthesis, characterization and evaluation of the biological activity of metalic complexes with dithiocarbimates / Síntese, caracterização e estudo da atividade biológica de complexos metálicos com ditiocarbimatos
The dithiocarbimates are structurally related to the dithiocarbamates, but are less studied. This work describes the syntheses of zinc(II), platinum(II) and gold(III) complexes with dithiocarbimates anions and their characterization by elemental analyses, conductance measurements, infrared, electronic, and NMR spectroscopies. Some substances were also charac
Publicado em: 2007