Piplartine
Mostrando 1-9 de 9 artigos, teses e dissertações.
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1. UM NOVO COMPLEXO HÍBRIDO FORMADO A PARTIR DE PIPLARTINA E O ÍON VANADILA: SÍNTESE, CARACTERIZAÇÃO E ESTUDO DA ATIVIDADE BIOLÓGICA
The synthesis, characterization and antimicrobial activity of novel vanadium (IV) complex derived of amide natural piplartine is reported. The minimum inhibitory concentrations (MIC) of complex, piplartine and vanadyl sulphate used in the synthesis were determined against six bacteria and one fungus. The complex exhibited good activity with minimal inhibitor
Quím. Nova. Publicado em: 2017-09
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2. Evaluation of larvicidal activity of the methanolic extracts of Piper alatabaccum branches and P. tuberculatum leaves and compounds isolated against Anopheles darlingi
Piper is a notable genus among Piperaceae due to their secondary metabolites such as lignans, amides, esters and long chain fatty acids used as anti-herbivore defenses with comparable effects of pyrethroids, that holds a promise in insect control, including malaria vectors such as Anopheles darlingi, the main vector in the North of Brazil. Methanolic extract
Rev. bras. farmacogn.. Publicado em: 03/04/2012
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3. Sensitive method for determination of piplartine, an alkaloid amide from Piper species, in rat plasma samples by liquid chromatography-tandem mass spectrometry
Piplartine (PPTN) is an alkaloid amide found in Piper species that presents different activities. PPTN determination in rat plasma is necessary to better understand its biological effects. The aim of this study was to develop a sensitive LC-MS/MS method for the determination of PPTN in rat plasma. The performance criteria for linearity, sensitivity, precisio
Química Nova. Publicado em: 2012
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4. Estudo dos efeitos comportamentais e neuroquÃmicos da piplartina, alcamida isolada de Piper tuberculatum JACQ., em camundongos / STUDY OF BEHAVIORAL AND NEUROBIOCHEMICAL EFFECTS OF PIPLARTINE, ALCAMIDE ISOLATED FROM PIPER TUBERCULATUM JACQ., IN MICE
Piper tuberculatum Jacq. (pimenta de macaco) à uma Piperaceae muito usada no Nordeste do Brasil como condimento ou remÃdio. A piplartina (PIP), uma alcamida isolada da planta, ainda à pouco estudada e isto incentivou a investigaÃÃo do seu potencial efeito comportamental e neurobioquÃmico. Os resultados mostraram que a PIP (50 e 100 mg/Kg, i.p.) aumento
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 21/08/2009
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5. Biological activity of amides and analogs from Piper species and synthetic analogs / Atividade biológica de amidas e análogos de espécies de Piper e estudos biossintéticos
Six amides were isolated from Piper scutifolium and P. corcovadensis including piperovatine, piperlonguminine, isopiperlonguminine and corcovadine, the new scutifoliamide A and scutifoliamide B and also two aristolactams (piperolactam C and stigmalactam). From P. tuberculatum the amides piplartine and pellitorine and two esters, ethyl (E)-3,4,5-trimethoxycin
Publicado em: 2009
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6. Estudo das propriedades anticÃncer da piplartina / Study of anticancer properties of piplartine
A piplartina à um alcalÃide/amida conhecido encontrado em espÃcies do gÃnero Piper com propriedade citotÃxica interessante. Para avaliar o seu potencial antineoplÃsico, um estudo farmacolÃgico de suas propriedades anticÃncer foi realizado em vÃrios modelos biolÃgicos. A piplartina apresentou potente atividade citotÃxica em todas as linhagens tumor
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 27/06/2008
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7. Biomimetic oxidative studies with the natural products piperine and piplartine. / Estudos oxidativos biomiméticos com os produtos naturais piperina e piplartina
Piperine and piplartine are alkaloids isolated from species of Piper genus. The choice of these molecules for this study was based on the promising biological activities presented by these substances, especially for their antitumoral potential. Based on the research of alternative ways for studying the metabolism of new drugs, especially from natural product
Publicado em: 2008
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8. In vivo growth-inhibition of Sarcoma 180 by piplartine and piperine, two alkaloid amides from Piper
Piplartine {5,6-dihydro-1-[1-oxo-3-(3,4,5-trimethoxyphenyl)-2-propenyl]-2(1H)pyridinone} and piperine {1-5-(1,3)-benzodioxol-5-yl)-1-oxo-2,4-pentadienyl]piperidine} are alkaloid amides isolated from Piper. Both have been reported to show cytotoxic activity towards several tumor cell lines. In the present study, the in vivo antitumor activity of these compoun
Brazilian Journal of Medical and Biological Research. Publicado em: 2006-06
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9. Anticancer potential of piplartine and piperine, amides isolated from piper species / Potencial anticâncer da piplartina e da piperina, amidas isoladas de plantas do gênero piper
Piplartine and piperine are alkaloids/amides isolated from Piper species. The activity of these compounds was initially evaluated on the brine shrimp lethality assay, sea urchin development, MTT assay using tumor cell lines, and hemolytic assay. Piperine showed a higher toxicity in brine shrimp than piplartine. Both piplartine and piperine inhibited the sea
Publicado em: 2005