Pindolol
Mostrando 1-12 de 28 artigos, teses e dissertações.
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1. Antinociceptive effect of semi-purified petroleum ether partition of Muntingia calabura leaves
ABSTRACT Muntingia calabura L., Muntingiaceae, is a medicinal plant for various pain-related diseases. The aims of the present study were to determine the antinociceptive profile and to elucidate the possible mechanisms of antinociception of petroleum ether partition obtained from crude methanol extract of M. calabura leaves using various animal models. The
Rev. bras. farmacogn.. Publicado em: 2016-08
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2. Efeitos antinociceptivo e gastroprotetor do óleo essencial da resina de Protium heptaphyllum March. (Burseraceae) e seu principal constituinte, o α-terpineol / Antinociceptive and gastroprotective effects of essential oil from the resin of Protium heptaphyllum March. (Burseraceae) and its main constituent, the α-terpineol
α-Terpineol, [2-(4-Metil-1-ciclohex-3-enil)propan-2-ol)], constituinte majoritário do óleo essencial da resina de Protium heptaphyllum March. (OEP) (Burseraceae), popularmente conhecida como almécega, foi avaliado em modelos experimentais de nocicepção (formalina, capsaicina, contorções abdominais e glutamato), lesões gástricas (indução por e
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 22/08/2011
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3. Antinociceptive effect on mice of the hydroalcoholic fraction and (-) epicatechin obtained from Combretum leprosum Mart & Eich
Previous studies on Combretum leprosum, a tree growing in the Northeastern states of Brazil, have shown antinociceptive effects of the ethanol extract of its leaves and bark, but studies examining its constituents are rare. The objective of this study was to evaluate the antinociceptive effect of the hydroalcoholic fraction (HF) of one of its constituents, t
Braz J Med Biol Res. Publicado em: 2010-12
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4. Redução do tempo de latência para o efeito antidepressivo pela administracao de pindolol / Pindolol as a means to decrease the latency period to obtain antidepressant effect
Diferentes fármacos antidepressivos aumentam os níveis extracelulares de serotonina (5-HT) nos núcleos da rafe e do mesencéfalo. Como resultado desse aumento, ocorre ativação dos autoreceptores somatodendríticos 5-HT1A que, por mecanismo de feedback negativo, determina uma subseqüente redução na liberação de 5-HT. Esse mecanismo tem sido implicad
Publicado em: 2010
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5. Cromatografia líquida com fase quiral aplicada na separação enantiomérica de fármacos cardiovasculares
A maioria dos agentes terapêuticos, freqüentemente prescritos, é formulada e comercializada sob a forma racêmica, embora, para alguns deles, já tenha sido demonstrado que os efeitos farmacológicos e/ou tóxicos estejam relacionados apenas a um dos enantiômeros. Além disso, é conhecido o fato de que os enantiômeros podem apresentar perfis farmacocin
Revista Brasileira de Ciências Farmacêuticas. Publicado em: 2006-12
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6. Depressão resistente a tratamento: uma revisão das estratégias farmacológicas de potencialização de antidepressivos
OBJETIVO: Fazer uma revisão sobre oito estratégias farmacológicas de potencialização de antidepressivos na DRT. MÉTODOS: Fez-se um levantamento bibliográfico de 1990 até janeiro de 2006, nas bases eletrônicas de busca Medline, LILACS e da Biblioteca Cochrane, utilizando-se os termos de busca treatment, resistant, refractory e depression e os descrit
Jornal Brasileiro de Psiquiatria. Publicado em: 2006
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7. Separação enantiomérica de fármacos em medicamentos por cromatografia líquida com fase estacionária quiral / Direct enantiomeric separation of drugs in pharmaceutical by high performance liquid chromatography with chiral stationary phase
The majority of the therapeutic agents, frequently prescribed, are formulated and commercialized as racemic mixture, even so for some of them, it has been demonstrated that the pharmacological and/or toxic effect are confined only to one of the enantiomer. Besides, it is well known that the enantiomers can present different pharmacokinetic and pharmacodynami
Publicado em: 2002
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8. Influencia da ciclofosfamida e do metotrexato sobre glandulas submandibulares estimuladas pela amputação dos incisivos inferiores em ratos machos castrados tratados pelo pindolol ou reserpina
Foi estudado o efeito da amputação dos incisivos inferiores s obre as glândulas submandibulares de ratos machos castrados. Demonstramos que nestes animais, injetados com metotrexato Q,75 mg/kg, i.p., e submetidos ã amputação dos in cisivos inferiores ,ocorre aumento do peso relativo das glându1as submandibu1ares - não ocorrendo o mesmo em ratos cas-
Publicado em: 1994
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9. Stereoselective renal clearance of pindolol in humans.
In this study, pindolol, a beta-adrenoceptor blocking agent marketed as a racemic mixture, was used as a model compound to investigate stereoselective renal clearance of organic cations in human beings. Six normal subjects received an oral dose of 20 mg racemic pindolol. Heart rate and blood pressure were measured throughout the study. A stereospecific high
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10. Effect of pindolol on intraocular pressure in glaucoma: pilot study and a randomised comparison with timolol.
A pilot study on 10 consecutive patients with newly diagnosed glaucoma and a randomised double-blind study on 18 patients with glaucoma were carried out to investigate the effect of pindolol, a beta-adrenergic blocking agent, on the intraocular pressure (IOP) in patients with glaucoma. The studies showed that pindolol may reduce the IOP and that no significa
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11. Addition of pindolol to routine medical therapy: a clinical trial.
A double-blind study of pindolol eye drops 0.5% was carried out on 24 patients with primary open-angle glaucoma. Pressures were taken once weekly during three 3-week periods. In one of the periods placebo was given in both eyes, during another pindolol was given in one eye, and during another it was given in the other eye. A drop in pressure averaging 2.79%
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12. Beta-blockers in bronchial asthma: effect of propranolol and pindolol on large and small airways.
In 11 asthmatic subjects the relative magnitude and the site of airway bronchoconstriction were compared after the oral administration of 40 mg of propranolol and 2.5 mg of pindolol and the magnitude and site of bronchodilation produced by 0.5 mg subcutaneous terbutaline were tested after pretreatment with propranolol and pindolol. Specific airway conductanc