Phenothiazines
Mostrando 1-12 de 44 artigos, teses e dissertações.
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1. Modelagem molecular aplicada ao estudo de reações de inibição enzimática com aplicação potencial no controle de Leishmania amazonensis. 2010. / Applied molecular modeling to the enzymatic inhibition reactions study with Leishmania amazonensis controls potential application. 2010.
Parasitic protozoan diseases, transmitted by blood-feeding insects, constitute the worlds most widely spread human health problem. It is estimated that three million people suffer from a parasitic infection (mainly trypanosomatid and apicomplexan parasites), responsible for important human diseases. The compounds here studied constitute the amidines and the
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 11/06/2010
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2. FOTODEGRADATION OF PHENOTHIAZINES AND THEIR STRUCTURAL EFFECTS ON NA(+)K(+) - ATPASE: A FLUORESCENCE STUDY / FOTODEGRADAÇÃO DE FENOTIAZINAS E SEUS EFEITOS ESTRUTURAIS SOBRE A NA(+), K(+) - ATPASE: ESTUDO ATRAVÉS DE FLUORESCÊNCIA
Chlorpromazine (CPZ), fluphenazine (FPZ) and trifluoperazine (TFP) are phenothiazine derivatives, which generate photoproducts under UV irradiation. We observed that CPZ develops three fluorescent fotoproducts under different conditions. Promazine (PZ) that forms from the CPZ photolysis. The chlorine loss is one of the main pathways for photoproduct formatio
Publicado em: 2010
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3. Emprego de polimeros de impressão molecular (MIP) na extração e pre-concentração de analitos organicos em amostras biologicas seguido de determinação espectrofotometrica / Use of moleculary imprinted polymers (MIP) for extraction and pre-concentration of orgnic analytes in biological samples and spectrophotometric determination
Essa Tese de Doutorado teve como objetivo promover a associação entre polímeros de impressão molecular (MIP) e espectrofotometria, sendo a seletividade conseguida pela ligação específica dos analitos com os sítios de reconhecimento molecular impresso no MIP. No capítulo 1 foi sintetizado e caracterizado um MIP seletivo a catecol, sendo o mesmo empre
Publicado em: 2009
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4. Synthesis and study of photoinduced properties of phenothiazine derivatives on biomimetic systems / Síntese e estudo das propriedades fotoinduzidas de derivados fenotiazínicos em sistemas biomiméticos
The effect of interfaces on photophysical and photochemical properties of methylene blue (MB) and its derivatives was studied in this work, aiming to emploit their potencial as photosensitizers (PS) in photodynamic therapy.The presence of MB in SDS solutions affect the micelle equilibrium decreasing the apparent critical micelle concentration of SDS from 7mm
Publicado em: 2008
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5. Estudo de sistemas de relevância biológica por espalhamento de raios X a baixos ângulos / Small angle x-Ray scattering study of biological relevant systems
Neste trabalho, utilizamos a técnica de espalhamento de raios-X a baixos Ângulos (SAXS) para estudar a influência de dois derivados fenotiazínicos na estrutura de sistemas micelares, assim como suas propriedades de auto-associação, além de investigar a influência da variação de pH e de concentração nas interações entre proteínas em solução.
Publicado em: 2008
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6. Reduction of molecular oxygen in aqueous solutions through modifying electrodesmethodology / Redução de oxigênio molecular em soluções aquosas através da metodologia de modificação de eletrodos
This work consisted in testing the viability of investigations into the electrochemical generation and identification of free radicals involved in advanced oxidative processes. In these studies, a technique which is rarely used for the electrochemical generation and identification of free radicals at organothiole-modified electrodes, electrochemical impedanc
Publicado em: 2007
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7. Emprego de diferentes estrategias para analises em larga escala : screening, extração ultra-sonica e pre-concentração por ponto nuvem
This thesis proposes three different procedures to simplify chemical analyses, mostly minimizing time and costs. In the first part, it was developed a screening system to detection of phenothiazines in human urine. A spectrophotometric method based on the reaction of the drugs with K3Fe(CN)6 in acid medium was proposed. The flow system was optimized and the
Publicado em: 2002
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8. Acute intermittent porphyria: clinical study of 37 cases. / Porfiria aguda intermitente: estudo clínico de 37 casos.
Acute intermittent porphyria is an autosomal dominant disease, caused by a disturbance in the heme biosynthetic pathway, secondary to the reduction on the levels of uroporphyrinogen-I-synthetase enzyme. Clinical manifestations involve central and peripheral nervous system. The diagnosis is based on the elevated urinary excretion of porphyrins precursors d-am
Publicado em: 2001
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9. Electrophysiological and biochemical studies on enhancement of desensitization by phenothiazine neuroleptics.
The actions of the phenothiazines chlorpromazine, prochlorperazine, and trifluoperazine were studied on the acetylcholine receptor-ionic channel complex of frog and rat skeletal muscle and of Torpedo californica to determine their role in pharmacological desensitization and their interactions with different states of the receptor-ionic channel complex. The p
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10. Phenothiazine drugs: structure-activity relationships explained by a conformation that mimics dopamine.
The antischizophrenic activity of phenothiazine drugs and their tendency to elicit extrapyramidal symptoms are thought to involve blockade of synaptic dopamine receptors in the brain. Space filling molecular models show how favorable Van der Waal's interactions between the side chain amino of phenothiazines and the 2-substituent on ring A can promote a confo
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11. On the calcium receptor activating exocytosis: inhibitory effects of calmodulin-interacting drugs on rat mast cells.
1. A series of neuroleptic drugs (five phenothiazines, imipramine, and pimozide) and the smooth muscle relaxant W-7, which all inhibit calcium-calmodulin-activated processes inhibited rat mast cell secretion elicited by antigen, by 48/80, and by the calcium ionophore A23187. 2. Neither the phenothiazines nor W-7 reduced 45Ca uptake in response to A23187. The
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12. Inhibition of human neutrophil chemotaxis in vitro by phenothiazines and related compounds.
Chlorpromazine (CPZ) and three other phenothiazines and the structurally related antidepressant drugs imipramine and amitriptyline were found to depress human neutrophil chemotactic responsiveness. A 7 X 10(-6)M solution of CPZ inhibited chemotaxis, whereas concentrations of the other tested drugs 10 to 1,000 times greater than this were needed to inhibit ch