Pharmaceutical Industry
Mostrando 25-36 de 291 artigos, teses e dissertações.
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25. Advances and challenges in therapeutic monoclonal antibodies drug development
The use of serum containing polyclonal antibodies from animals immunized with toxins marked the beginning of the application of antibody-based therapy in late nineteenth century. Advances in basic research led to the development of the hybridoma technology in 1975. Eleven years later, the first therapeutic monoclonal antibody (mAb) was approved, and since th
Braz. J. Pharm. Sci.. Publicado em: 08/11/2018
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26. Athelia (Sclerotium) rolfsii in Allium sativum: potential biocontrol agents and their effects on plant metabolites
Abstract Garlic (Allium sativum L.) plays an important role in popular culture due to its dietary and medicinal uses. It is also used to produce a wide range of pharmacologically interesting molecules. Several pathogens affect garlic plants, especially Athelia (Sclerotium) rolfsii, a fungus that is widespread and causes large economic losses. It causes direc
An. Acad. Bras. Ciênc.. Publicado em: 01/11/2018
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27. Identification of Ethyl and t-Butyl Glyceryl Ethers Using Gas Chromatography Coupled with Mass Spectrometry
The ethers produced through the etherification reaction of glycerol with ethanol or t-butanol are used as oxygenated fuel additives, intermediates in the pharmaceutical industry, and non-ionic surfactants. However, the identification of these ethers has not been accurately done, because only some mass spectra of these compounds are available in the libraries
J. Braz. Chem. Soc.. Publicado em: 2018-06
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28. Recent Advances and Perspectives in Cancer Drug Design
ABSTRACT Cancer is one of the leading causes of death worldwide. With the increase in life expectancy, the number of cancer cases has reached unprecedented levels. In this scenario, the pharmaceutical industry has made significant investments in this therapeutic area. Despite these efforts, cancer drug research remains a remarkably challenging field, and the
An. Acad. Bras. Ciênc.. Publicado em: 14/05/2018
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29. Karyotype and genome size comparative analyses among six species of the oilseed-bearing genus Jatropha (Euphorbiaceae)
Abstract Jatropha is an important genus of Euphorbiaceae, with species largely used for various purposes, including the manufacturing of soaps and pharmaceutical products and applications in the bioenergetic industry. Although there have been several studies focusing J. curcas in various aspects, the karyotype features of Jatropha species are poorly known. T
Genet. Mol. Biol.. Publicado em: 14/05/2018
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30. Physical characterization of multiparticulate systems
ABSTRACT The search for new pharmaceutical dosage forms and different drug delivery systems already used in therapeutics is a global trend, serving as an opportunity to expand the portfolio for the pharmaceutical industry. In this context, multiparticulate systems, such as pellets, granules, and minitablets, represent an attractive alternative, given the ran
Braz. J. Pharm. Sci.. Publicado em: 07/05/2018
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31. From Medicinal Chemistry to Human Health: Current Approaches to Drug Discovery for Cancer and Neglected Tropical Diseases
ABSTRACT Scientific and technological breakthroughs have compelled the current players in drug discovery to increasingly incorporate knowledge-based approaches. This evolving paradigm, which has its roots attached to the recent advances in medicinal chemistry, molecular and structural biology, has unprecedentedly demanded the development of up-to-date comput
An. Acad. Bras. Ciênc.. Publicado em: 15/02/2018
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32. Reproductive Biology of Varronia curassavica Jacq. (Boraginaceae)
ABSTRACT Varronia curassavica, a subshrubby medicinal species associated with restinga in the Atlantic Forest, has been exploited by local people and the pharmaceutical industry. Indeed, restingas have experienced a continuous process of degradation, and thus, with species and ecosystem both at risk, efforts to support conservation actions are required. The
An. Acad. Bras. Ciênc.. Publicado em: 01/02/2018
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33. ABORDAGEM DIDÁTICA PARA O DESENVOLVIMENTO DE MOLÉCULAS BIOATIVAS: REGRA DOS CINCO DE LIPINSKI E PREPARAÇÃO DE HETEROCICLO 1,3,4-OXADIAZOL EM FORNO DE MICRO-ONDAS DOMÉSTICO
In Brazil, the development of new chemical entities (NEQ) is still limited to small advances in the academic and public research sectors, the authors understand that this is a sector of the pharmaceutical industry that needs encouragement. Accepting that education transforms society, educate students in the development of bioactive molecules, it’s a way to
Quím. Nova. Publicado em: 2018-01
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34. Economy class syndrome: what is it and who are the individuals at risk?
Abstract The term 'economy class syndrome' refers to the occurrence of thrombotic events during long-haul flights that mainly occur in passengers in the economy class of the aircraft. This syndrome results from several factors related to the aircraft cabin (immobilization, hypobaric hypoxia and low humidity) and the passenger (body mass index, thrombophilia,
Rev. Bras. Hematol. Hemoter.. Publicado em: 2017-12
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35. Complete sequence and comparative analysis of the chloroplast genome of Plinia trunciflora
Abstract Plinia trunciflora is a Brazilian native fruit tree from the Myrtaceae family, also known as jaboticaba. This species has great potential by its fruit production. Due to the high content of essential oils in their leaves and of anthocyanins in the fruits, there is also an increasing interest by the pharmaceutical industry. Nevertheless, there are fe
Genet. Mol. Biol.. Publicado em: 06/11/2017
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36. Developmental Toxicity of (4S)-2- (4-hydroxy-3-methoxyphenyl) thiazolidine-4-carboxylic acid in Zebrafish ( Danio rerio )
ABSTRACT (4S)-2-(4-hydroxy-3-methoxyphenyl)thiazolidine-4-carboxylic acid is new synthesized substance obtained from cysteine and valine. Thiazolidine derivates have important biological responses so scientists work intensively on these compounds in recent years. It is obvious that thiazolidine contained compounds will be used in future in the pharmaceutical
Braz. arch. biol. technol.. Publicado em: 21/08/2017