Pharmaceutical Forms
Mostrando 1-12 de 93 artigos, teses e dissertações.
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1. Simultaneous Quantification of Amorphous and Crystalline Valsartan in Tablets Using Raman Spectroscopy and Chemometrics Tools
Valsartan is an antihypertensive active pharmaceutical ingredient (API), it is used in the amorphous state in the commercial products. As amorphous materials are metastable, amorphous valsartan can crystallize to valsartan E, promoting changes in the dissolution and bioavailability of the drug. Tablets containing metastable forms of APIs need special conditi
Journal of the Brazilian Chemical Society. Publicado em: 2022
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2. HORMÔNIOS NA PRODUÇÃO DE MODOS DE SUBJETIVAÇÃO: ATUANDO CONTROVÉRSIAS
Resumo Este artigo visa analisar agenciamentos produzidos pelos hormônios na conformação de modos de subjetivação contemporâneos. A abordagem teórico-metodológica adotada se alinha aos estudos de Michel Foucault, especialmente em seus escritos sobre modos de subjetivação, e se aproxima de alguns conceitos postulados por pesquisadores alinhados à T
Psicol. Soc.. Publicado em: 20/12/2019
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3. Preformulation of a liquid dosage formulation of captopril for pediatric use: drug-excipient compatibility and stability studies
Currently, medications used in children are typically modified from pharmaceutical dosage forms designed for adults. Captopril is widely adapted to liquid formulations for use in hospitals. Its stability in the aqueous medium is reduced since it undergoes oxidation producing captopril disulfide (its main metabolite). The aim of this formulation study was to
Braz. J. Pharm. Sci.. Publicado em: 20/12/2019
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4. Desenvolvimento e caracterização de membranas de quitosana / Cissus Verticillata (L.) Nicolson & C.E. Jarvis
RESUMO Os polímeros, devido às suas diversas aplicações e funcionalidades, estão entre os excipientes mais utilizados para a obtenção de formas farmacêuticas, ganhando destaque a quitosana. O objetivo deste trabalho foi desenvolver e avaliar comparativamente membranas de quitosana com diferentes concentrações da espécie vegetal Cissus verticillata
Matéria (Rio J.). Publicado em: 16/09/2019
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5. A Novel Thermal Infrared Enthalpimetric Method for Fast, High-Throughput Determination of the Content Uniformity of Captopril Tablets
Content uniformity (CU) is a parameter used to ensure the uniformity of the amount of active substances in pharmaceutical preparations. It is often evaluated in the quality control of pharmaceutical dosage forms, and a novel method was proposed for CU determination using thermal infrared enthalpimetry (TIE). Captopril tablets were dissolved in 24-well microp
J. Braz. Chem. Soc.. Publicado em: 08/04/2019
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6. Embodied values: post-pharmaceutical health and the accumulation of surplus vitality in regenerative stem cell medicine
Resumo Este artigo analisa uma forma emergente de saúde pós-farmacêutica e seu regime implícito de valor na bioeconomia global da medicina regenerativa baseada em células-tronco (MRCT). Estimulada por uma perspectiva de superação das terapias baseadas em medicação e suas economias políticas subjacentes, a medicina regenerativa com células-tronco (
Sociologias. Publicado em: 2019-04
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7. Challenges to improve the biopharmaceutical properties of poorly water-soluble drugs and the application of the solid dispersion technology
ABSTRACT The oral solid dosage forms are extremely relevant to drug therapy and responsible for much of the pharmaceutical industry turnover worldwide. However, the development of medicines in solid form involves significant challenges, including obtaining formulations with appropriate bioavailability for low aqueous solubility drugs (classes II and IV of th
Matéria (Rio J.). Publicado em: 06/12/2018
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8. Stability indicating RP-HPLC method development and validation of cefepime and amikacin in pure and pharmaceutical dosage forms
A simple, accurate, isocratic stability indicating RP-HPLC method was developed for the determination of cefepime and amikacin in Pure and its pharmaceutical formulations. The method consists of methanol: acetonitrile:acetate buffer 75:20:05 (v/v) mobile phase at pH 5.1 with C18 column as stationary phase. The flow rate and detection wave length were 1.0 mL/
Braz. J. Pharm. Sci.. Publicado em: 29/11/2018
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9. Physical characterization of multiparticulate systems
ABSTRACT The search for new pharmaceutical dosage forms and different drug delivery systems already used in therapeutics is a global trend, serving as an opportunity to expand the portfolio for the pharmaceutical industry. In this context, multiparticulate systems, such as pellets, granules, and minitablets, represent an attractive alternative, given the ran
Braz. J. Pharm. Sci.. Publicado em: 07/05/2018
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10. Solubility and dissolution studies of tibolone polymorphs
ABSTRACT Different solid forms of an active pharmaceutical ingredient can have distinct chemical and physical characteristics. In this work, we studied the solubility and dissolution properties of the described tibolone polymorphic forms (I and II). Both forms were successively recrystallized and characterized by powder X-ray diffraction and attenuated total
Braz. J. Pharm. Sci.. Publicado em: 05/03/2018
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11. Prednisone raw material characterization and formulation development
ABSTRACT Solid dosage forms for oral use, particularly tablets, are the most highly used dosage forms in therapy because they are easily administered, have high productivity and relatively low cost and provide a more stable drug to form a semi-solid net. Numerous parameters influence the quality of the final dosage form. In this study, the dissolution profil
Braz. J. Pharm. Sci.. Publicado em: 08/01/2018
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12. Implementation of a Spectrofluorimetric Method to the Determination of 8-Methoxypsoralen in Capsules and Creams Used in Treatment of Psoriasis and Vitiligo: an Evaluation of the Quality of Compounding Pharmacies in Rio de Janeiro
8-Methoxypsoralen is a widely sold drug in Brazil as handled capsules and creams because it is only industrially available as soft gel capsules of 10 mg. In order to contribute to the quality control of these pharmaceutical forms, a spectrofluorimetric method was implemented and applied for the evaluation of the quality of compounding pharmacies in the state
J. Braz. Chem. Soc.. Publicado em: 2017-08