Organoselenium
Mostrando 1-12 de 22 artigos, teses e dissertações.
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1. Atheroprotective action of a modified organoselenium compound: in vitro evidence
RESUMO A oxidação da lipoproteína de baixa densidade (LDL) apresenta um papel importante na patogênese da aterosclerose. Nesse sentido, reduzir a oxidação da LDL é uma abordagem importante para diminuir o risco de aterosclerose. Compostos orgânicos de selênio têm demonstrado propriedades ateroprotetoras promissoras em modelos experimentais. Neste e
An. Acad. Bras. Ciênc.. Publicado em: 10/10/2016
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2. EFEITOS DE COMPOSTOS ORGÂNICOS DE SELÊNIO FRENTE À TOXICIDADE INDUZIDA POR GLUTAMATO E METILMERCÚRIO / EFFECTS OF ORGANOSELENIUM COMPOUNDS AGAINST THE TOXICITY INDUCED BY GLUTAMATE OR METHYLMERCURY
Os compostos orgânicos de selênio têm sido propostos como potenciais agentes farmacológicos para o tratamento de patologias associadas ao estresse oxidativo. Em particular, o disseleneto de difenila e o ebselen têm sido demonstrados como potentes agentes antioxidantes em uma variedade de modelos experimentais. Dessa forma, os objetivos do presente estud
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 02/03/2012
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3. 2,2-DISSELENETO DE DITIENILA, UM COMPOSTO ORGÂNICO DE SELÊNIO COM ATIVIDADE ANTIOXIDANTE E NEUROPROTETORA EM RATOS / 2,2-DITHIENYL DISELENIDE, AN ORGANOSELENIUM COMPOUND WITH ANTIOXIDANT AND NEUROPROTECTIVE ACTIVITIES IN RATS
O estresse oxidativo tem sido implicado na patofisiologia de diversas doenças neurológicas uma vez que o cérebro é um órgão altamente susceptível ao dano oxidativo. A epilepsia do lobo temporal (ELT) tem sido amplamente estudada devido à alta taxa de prevalência e refratariedade ao tratamento medicamentoso. Além disso, a ELT pode estar associada co
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 02/03/2012
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4. PERFIL FARMACOLÓGICO DO TIPO ANTIDEPRESSIVO DO COMPOSTO 3-(4-FLUOROFENILSELENIL)-2,5 DIFENILSELENOFENO: ENVOLVIMENTO DO SISTEMA SEROTONINÉRGICO / ANTIDEPRESSANT-LIKE PHARMACOLOGICAL PROFILE OF 3-(4- FLUOROPHENYLSELENYL)-2,5-DIPHENYLSELENOPHENE: INVOLVEMENT OF SEROTONERGIC SYSTEM
Depression is a serious, recurrent and incapacitating psychiatric condition with a heavy social burden. The pharmacological approach to this disorder employs therapy with antidepressant drugs, which have side effects and numerous limitations. In view of the promising pharmacological properties of containing-selenium molecules, this study evaluated the effect
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 23/02/2011
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5. Protective effects of organoselenium compounds against methylmercury-induced oxidative stress in mouse brain mitochondrial-enriched fractions
We evaluated the potential neuroprotective effect of 1-100 µM of four organoselenium compounds: diphenyl diselenide, 3’3-ditri-fluoromethyldiphenyl diselenide, p-methoxy-diphenyl diselenide, and p-chloro-diphenyl diselenide, against methylmercury-induced mitochondrial dysfunction and oxidative stress in mitochondrial-enriched fractions from adult Swiss mo
Brazilian Journal of Medical and Biological Research. Publicado em: 2011-11
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6. Pharmacology and toxicology of diphenyl diselenide in several biological models
The pharmacology of synthetic organoselenium compounds indicates that they can be used as antioxidants, enzyme inhibitors, neuroprotectors, anti-tumor and anti-infectious agents, and immunomodulators. In this review, we focus on the effects of diphenyl diselenide (DPDS) in various biological model organisms. DPDS possesses antioxidant activity, confirmed in
Publicado em: 2010
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7. Chemoenzymatic synthesis of organoselenium(IV) compounds and their evaluation as cysteine protease inhibitors
Uma série de organosselenanas foi sintetizada utilizando-se uma metodologia quimio-enzimática. Estas organosselenanas apresentam variações na estereoquímica e no halogênio ligado ao átomo de selênio. Devido à reação característica envolvendo compostos de selênio e tióis, estas organosselenanas foram avaliadas como inibidores de cisteíno protea
Journal of the Brazilian Chemical Society. Publicado em: 2010
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8. EFEITO DO TIPO ANTIDEPRESSIVO DO DISSELENETO DE DIFENILA EM UM MODELO DE DEPRESSÃO INDUZIDA POR MALATION EM RATOS / ANTIDEPRESSANT-LIKE EFFECT OF DIPHENYL DISELENIDE ON MALATIONINDUCED DEPRESSION MODEL IN RATS
Organophosphorus (OP), among them malathion, are responsible for most of the poisonings reported annually in Brazil. In addition to symptoms of cholinergic poisoning, the exposure to OP causes affective and cognitive disorders, which are not necessarily related to acetylcholinesterase (AChE) enzyme activity inhibition. One of these disorders is depression. D
Publicado em: 2010
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9. AVALIAÇÃO TOXICOLÓGICA DE ORGANOCALCOGÊNIOS EM ERITRÓCITOS HUMANOS / TOXICOLOGICAL EVALUATION OF ORGANOCHALCOGENS IN HUMAN ERYTHROCYTES
The interest in organochalcogen chemistry, biochemistry and pharmacology has increased in the last two decades mainly due to the fact that a variety of organochalcogen compounds possess biological activity and due the use of these compounds in industrial applications. However, literature data showed that these compounds present pro-oxidant properties, causin
Publicado em: 2009
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10. TOXICOLOGIA E FARMACOLOGIA IN VITRO DE NOVOS COMPOSTOS ORGÂNICOS DE SELÊNIO E TELÚRIO COM ATIVIDADE TIPO TIOL PEROXIDASE / TOXICOLOGY AND PHARMACOLOGY OF NEW SELENIUM AND TELLURIUM ORGANIC COMPOUNDS IN VITRO WITH THIOL PEROXIDASE ACTIVITY
Glutathione peroxidase (GPx; EC 1.11.1.9) is a well-known selenoenzyme that catalyzes the reduction of hydrogen peroxide and some organic hydroperoxides by glutathione (GSH) and protects lipid membranes and other cellular components against oxidative stress, which is related to many diseases and this enzyme is regarded as one of the most important antioxidan
Publicado em: 2009
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11. Síntese de organo-seleno aminas e sua resolução cinética via reação de acetilação enantiosseletiva mediada por lipases / Synthesis of organoselenium amines and their kinetic resolution by enantioselective acetylation mediated by lipases
In this work, we have developed a chemoenzymatic method to enantiomerically synthesize enriched organoselenium amines (1-(2, 3 or 4 -(ethylselanyl)phenyl)ethanamine) and amides (N-(1-(2, 3 or 4-(ethylselanyl)phenyl)ethyl)acetamide). Initially, the organoselenium amines, in the racemic form, were synthesized from ortho-, meta- and para- aminoacetophenones. Th
Publicado em: 2008
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12. Pharmacology and toxicology of diphenyl diselenide in several biological models
The pharmacology of synthetic organoselenium compounds indicates that they can be used as antioxidants, enzyme inhibitors, neuroprotectors, anti-tumor and anti-infectious agents, and immunomodulators. In this review, we focus on the effects of diphenyl diselenide (DPDS) in various biological model organisms. DPDS possesses antioxidant activity, confirmed in
Brazilian Journal of Medical and Biological Research. Publicado em: 21/08/2007