Oligonucleotide Based Therapies
Mostrando 1-4 de 4 artigos, teses e dissertações.
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1. Arranjos supramoleculares de oligodeoxinucleotídeos e fragmentos de bicamada catiônica: preparação, caracterização e atividade imunoadjuvante / Supramolecular assemblies of oligodeoxynucleotides and cationic bilayer fragments: preparation, characterization and immunoadjuvant activity
A interação entre fragmentos de bicamada (BF) de brometo de dioctadecildimetilamônio (DODAB) e um mononucleotídeo-modelo (deoxiadenosina monofosfato, dAMP) ou um oligodeoxinucleotídeo-modelo (5- AAAAAAAAAA-3, poli(dA)) ou um oligodeoxinucleotídeo terapêutico (5- TTGACGTTCG -3, CpG) foi investigada por turbidimetria, espalhamento de luz dinâmico, espe
Publicado em: 2011
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2. Triplex-forming oligonucleotide target sequences in the human genome
The existence of sequences in the human genome which can be a target for triplex formation, and accordingly are candidates for anti-gene therapies, has been studied by using bioinformatics tools. It was found that the population of triplex-forming oligonucleotide target sequences (TTS) is much more abundant than that expected from simple random models. The p
Oxford University Press.
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3. Targeting RNA for degradation with a (2'-5')oligoadenylate-antisense chimera.
Antisense oligonucleotides hold considerable promise both as research tools for inhibiting gene expression and as agents for the treatment of a myriad of human diseases. However, targeted destruction of RNA has been difficult to achieve in a versatile, efficient, and reliable manner. We have developed an effective strategy for cleaving unique RNA sequences w
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4. Detection of human immunodeficiency virus type 1 RNA in plasma samples from high-risk pediatric patients by using the self-sustained sequence replication reaction.
There is an urgent need for rapid and sensitive methods to assess human immunodeficiency virus (HIV) infection in infants and children. We evaluated an approach by using the self-sustained sequence replication reaction (3SR) to amplify HIV type 1 (HIV-1) RNA directly. The amplified RNA product was then detected by bead-based sandwich oligonucleotide capture