Oil Core Self Organized Chitosan Nanovesicles
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1. Desenvolvimento, caracterização físico-química e avaliação farmacocinética de nanopartículas auto-organizadas de quitosana / Development, physico-chemical characterization and pharmacokinetic evaluation of self-assembly chitosan nanoparticules
Objectives: Nanoparticles (NP) are useful to modulate the pharmacokinetics (PK) of drugs. The aim of this study was to develop innovative self-assembly nanovesicles (NV) constituted of chitosan and lecithin with isopropyl myristate (IPM) as oil core, able to modify the PK plasma profile of clozapine (CZP) and valproic acid (VPA). Methods: The NV were obtaine
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 2012