Nucleosides
Mostrando 13-24 de 620 artigos, teses e dissertações.
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13. Ectonucleotidase activities in Sertoli cells from immature rats
Sertoli cells have been shown to be targets for extracellular purines such as ATP and adenosine. These purines evoke responses in Sertoli cells through two subtypes of purinoreceptors, P2Y2 and PA1. The signals to purinoreceptors are usually terminated by the action of ectonucleotidases. To demonstrate these enzymatic activities, we cultured rat Sertoli cell
Publicado em: 2010
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14. Simple method for fast deprotection of nucleosides by triethylamine-catalyzed methanolysis of acetates in aqueous medium
Este trabalho apresenta um método simples, rápido e eficiente para a desacetilação de ribonucleosídeos acetilados, a partir de metanólise catalisada por trietilamina em meio aquoso. As transformações assistidas por micro-ondas favoreceram sensivelmente a velocidade de reação e forneceram os nucleosídeos desprotegidos em altos rendimentos e sob con
Journal of the Brazilian Chemical Society. Publicado em: 2010
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15. Química supramolecular de fármacos antirretrovirais inibidores nucleosídeos de transcriptase reversa: novas formas cristalinas e alteração de propriedades de estado sólido / Supramolecular chemistry of antiretroviral nucleoside reverse transcriptase inhibitor drugs
Solid state properties are directly related to drug performance. Among all physical and chemical properties dependent on the crystal phase of a drug, stability and solubility are the main ones that alter its bioavailability. In this way, molecular crystal engineering is a strategy to improve solid state properties of drugs related to their efficacies. In thi
Publicado em: 2010
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16. AVALIAÇÃO DA ATIVIDADE DE ECTONUCLEOTIDASES NO CÓRTEX CEREBRAL E PLAQUETAS DE RATOS EXPOSTOS À FUMAÇA DE CIGARRO
Inflammatory and degenerative pathophysiological processes within the central nervous system (CNS) and platelets are important causes of human disease promoted by cigarette smoke. The objective of the present study was to evaluate activity of the enzymes that hydrolyze nucleotides and nucleosides in synaptosomes of cerebral cortex and platelets from rats exp
Publicado em: 2009
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17. Functional and structural characterization of nucleotidase SurE from Xyllela fastidiosa / Caracterização funcional e estrutural da nucleotidase SurE de Xyllela fastidiosa
A linhagem 9a5c da bactéria Xylella fastidiosa foi o primeiro fitopatógeno a ter seu genoma completamente sequenciado, o qual gerdu diversas informações sobre seu metabolismo e patogenicidade. Das orfs codificadas por esta bactéria, destaca-se; no presente trabalho, a XF0703, cuja proteína correlata (com 28,3 kDa) possui similaridade com proteínas Sur
Publicado em: 2009
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18. N- Alkylation reaction study on pyrimidin-2-ones: Synthesis of new modified nucleosides analogues / Estudo de reações de N-alquilação de pirimidin-2-onas: síntese de novos análogos nucleosídicos modificados
Este trabalho apresenta um estudo das reações de N-alquilação de 4-triclorometil-1H-pirimidin-2-ona (4), citosina (5), 5-bromo-4-metóxi-4-triclorometil-1,3H-pirimidin-2-ona (6), 4-metóxi-4-triclorometil-1,3H-pirimidin-2-ona (7), 3-benzoil-1H-pirimidina-2,4-diona (ou 3-benzoil-uracila) (8), 3-benzoil-5-metil-1H-pirimidina-2,4-diona (ou 3-benzoil-timina)
Publicado em: 2008
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19. Constituintes químicos da ascídia didemnum psammatodes (sluiter, 1895) coletada na costa cearense
Chemical investigation of the methanolic extract of the ascidian Didemnum psammatodes has led to the identification of the nucleosides 2'-deoxyuridine (1), thymidine (2), 2'-deoxyinosine (3) and 2'-deoxyguanosine (4), the steroids cholestanol, cholestanone and stigmasterol in mixture and batyl alcohol plus two analogs, 1-heptadecyloxy-2,3-propanediol and 1-n
Química Nova. Publicado em: 2007-10
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20. SÃntese de GlicopiranosÃdeos 2,3 - insaturados acoplados a heterociclos em C-4. FuncionalizaÃÃo da posiÃÃo C-5 de glicoheterociclos 4â â (5 â halo â uracil â l â il) atravÃs de reaÃÃes catalisadas por Pd (0)
In the last years, catalytic reactions promoted by palladium(0) complexes have been successful used in some couplings reactions between carbohydrates and heterocycles compounds like nucleophiles for the synthesis of nucleosides and nucleotides with interesting antiviral and antitumor activities. During the last 20 years, palladium(0) complexes have also been
Publicado em: 2007
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21. Sample optimization for rapid identification of nucleosides and bases from ascidian extracts using ESI-MS/MS
Um método de espectrometria de massas sequencial com ionização por electrospray (IES-EM/EM) foi desenvolvido para identificação dos nucleosídeos e bases em extratos de ascídias. Para este fim realizamos um estudo sistemático de preparo de amostra associado à análise de fragmentação de uma série de nucleosídeos e bases em IES-EM/EM. Estas aborda
Journal of the Brazilian Chemical Society. Publicado em: 2007
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22. Adducts of 2-desoxiadenosine and 2-desoxicitydine induced of tetrahydrofuran: structural characterization and detection in DNA / Adutos de 2-desoxiadenosina e 2-desoxicitidina induzidos por tetraidrofurano: caracterização estrutural e detecção em DNA
There is a huge concern to identify compounds involved in the development of harmful processes, like cancer. Tetrahydrofuran (THF) is a solvent widely used in industries and recent researches and studies indicated a carcinogenic activity in experimental animals, instigating the investigation of its possible interaction with biomolecules. DNA adducts are used
Publicado em: 2007
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23. Chemical study and evaluation of cytotoxic activity from ascidians Didemnum psammatodes (Sluiter, 1895) and Eudistoma vannamei Millar, 1977 (Tunicata: Ascidiacea) / Estudo químico e avaliação da atividade citotóxica das ascídias Didemnum psammatodes(Sluiter, 1885) e Eudistoma vannameiMillar, 1977 (Tunicata: Ascidiacea)
Samples of Didemnum psammatodes were collected in Icapui (Ceara State) and Trairi (Ceara State). The methanolic extract from D. psammatodes, acquired from Icapui, was submitted to fractionation and purification through several chromatographic techniques and were obtained four nucleosides (2?-deoxyuridine, 2- deoxyinosine, thyimidine, and 2?-deoxyguanosine),
Publicado em: 2006
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24. HIV-1 genotypes related to failure of nelfinavir as the first protease inhibitor treatment
Combined antiretroviral therapy results in sustained viral suppression and a decrease in mortality and morbidity due to HIV infection. Intrinsic strength, durability and absence of cross-resistance are key factors in the selection of antiretrovirals. Failure with nelfinavir has been associated with two protease gene mutations, D30N and L90M. The D30N mutatio
Brazilian Journal of Infectious Diseases. Publicado em: 2005-08