Nmda Receptors
Mostrando 13-24 de 412 artigos, teses e dissertações.
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13. Participation of neuronal nitric oxide synthase in experimental neuropathic pain induced by sciatic nerve transection
Nerve injury leads to a neuropathic pain state that results from central sensitization. This phenomenom is mediated by NMDA receptors and may involve the production of nitric oxide (NO). In this study, we investigated the expression of the neuronal isoform of NO synthase (nNOS) in the spinal cord of 3-month-old male, Wistar rats after sciatic nerve transecti
Brazilian Journal of Medical and Biological Research. Publicado em: 2010-04
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14. Núcleo mediano da rafe e estresse de nado forçado: papel dos receptores de glutamato de tipo NMDA / Median Raphe Nucleus and Forced Swim stress: role of glutamate NMDA receptors
Exposure to uncontrollable stressors leads to behavioral and neurochemical changes, which has been associated to mal functioning of the Median Raphe Nucleus (MnRN)-Dorsal Hippocampus (DH) serotoninergic pathway. These deficits can be attenuated by intra-hippocampal injections of NMDA antagonists or 5-HT1a agonists. Activation of MnRN glutamatergic NMDA recep
Publicado em: 2010
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15. Increased training prevents the impairing effect of intra-amygdala infusion of the non-NMDA receptor antagonist CNQX on inhibitory avoidance expression
Intra-amygdala infusion of the non-N-methyl-D-aspartate (NMDA) receptor antagonist 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) prior to testing impairs inhibitory avoidance retention test performance. Increased training attenuates the impairing effects of amygdala lesions and intra-amygdala infusions of CNQX. The objective of the present study was to determi
Publicado em: 2010
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16. CREATINE INCREASES Na+,K+-ATPase ACTIVITY AND PREVENTS SEIZURES INDUCED BY PENTYLENETETRAZOLE IN RATS / CREATINA AUMENTA A ATIVIDADE DA Na+,K+-ATPase E PREVINE O APARECIMENTO DAS CONVULSÕES INDUZIDAS POR PENTILENOTETRAZOL EM RATOS
Creatine, an endogenous guanidino compound produced on liver, kidneys, pancreas, testes and brain, has been aim of several studies over the last years. Although most studies attribute the effects of creatine to their energetic buffer role, recent findings have suggested actions non-related to energy metabolism. Researches have shown that this compound may ac
Publicado em: 2010
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17. Expressão gênica de receptores e da catalase no circuito de recompensa de camundongos sensibilizados e não sensibilizados aos efeitos estimulantes do etanol / Receptors and catalase gene expression in the reward circuit of sensitized and non-sensitized mice to the stimulant effect of ethanol
Entre as neuroadaptações que podem contribuir para o desenvolvimento de dependência do álcool está a sensibilização comportamental definida como um aumento na locomoção ou efeito estimulante após administração repetida da mesma dose de etanol (ETOH) ou outra droga. Este fenômeno ocorre devido à repetida ativação do circuito de recompensa cere
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 28/10/2009
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18. NMDA receptor blockade alters the intracellular distribution of neuronal nitric oxide synthase in the superficial layers of the rat superior colliculus
Nitric oxide (NO) is a molecular messenger involved in several events of synaptic plasticity in the central nervous system. Ca2+ influx through the N-methyl-D-aspartate receptor (NMDAR) triggers the synthesis of NO by activating the enzyme neuronal nitric oxide synthase (nNOS) in postsynaptic densities. Therefore, NMDAR and nNOS are part of the intricate sce
Brazilian Journal of Medical and Biological Research. Publicado em: 2009-02
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19. Crises paroxísticas recorrentes em ratos por inibição do transporte de glutamato durante o desenvolvimento / Genesis of recurrent epileptic paroxysmal burst in newborn rats after inhibition of glutamate transporters
It has been previously shown that cell-surface glutamate transporters efficiently control network activity in the maturing rodent brain, preventing the generation of seizures. In particular, inhibition of glutamate transporters by DL-TBOA leads to a pathological EEG pattern in freely moving rat pups. This is composed of partial seizures and recurrent short p
Publicado em: 2009
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20. Distribuição de receptores ionotrópicos de glutamato e sua co-localização com a fosfoproteína neural DARPP-32 no córtex pré-frontal de ratos. / Distribution of ionotropic glutamate receptors and their co-localization with the phosphoprotein DARPP-32 in the medial prefrontal córtex of rats.
O córtex pré-frontal medial (PFCm) é caracterizado por entradas glutamatérgicas e dopaminérgicas que convergem sobre os mesmos neurônios alvos. Devido à escassa informação sobre as bases anatômicas das interações entre a dopamina (DA) e o glutamato (Glu), mapeamos a distribuição de subunidades (Su) de receptores (Rs) de Glu do tipo AMPA, NMDA e
Publicado em: 2009
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21. Expression of neuronal nitric oxide synthase in the hippocampal formation in affective disorders
Hippocampal output is increased in affective disorders and is mediated by increased glutamatergic input via N-methyl-D-aspartate (NMDA) receptor and moderated by antidepressant treatment. Activation of NMDA receptors by glutamate evokes the release of nitric oxide (NO) by the activation of neuronal nitric oxide synthase (nNOS). The human hippocampus contains
Brazilian Journal of Medical and Biological Research. Publicado em: 2008-04
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22. Sistema canabinóide e seu possível papel em processos de neuroproteção e plasticidade: estudos in vivo e in vitro. / The cannabinoid system and its possible role in neuroprotection and plasticity processes: in vivo and in vitro studies.
The cannabinoid system (CS) seems to have a role in several neurobiological processes, including neuroprotection and neuronal plasticity. The aims of this study were to verify the effects of unilateral retinal ablation on the expression of cannabinoid receptor CB1 and other structural proteins in the optic tectum of chick brain by immunohistochemistry, immun
Publicado em: 2008
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23. Expressão dos receptores de glutamato do tipo NMDA em aves durante o desenvolvimento e envelhecimento / Expression of NMDA type glutamate receptors in the cerebellum of birds during aging
Aging is a physiologic process that takes place in a non-synchronic way in different areas of the brain and which can be defined as a dynamic and progressive process. There are morphological, functional and biochemical alterations which can lead to cognitive, affective, learning, memory and motor deficiencies. Since the cerebellum and the glutamatergic neuro
Publicado em: 2008
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24. Envolvimento do sistema GABAérgico nas alterações comportamentais eletrencefalográficas e neuroquímicas induzidas pela injeção de metilmalonato no ventrículo de ratos
O ácido metilmalônico (MMA) é um agente convulsivante endógeno que se acumula na acidemia metilmalônica, um erro inato no metabolismo caracterizado por disfunções neurológicas severas, predispondo ao aparecimento de convulsão. O mecanismo responsável pelas convulsões induzidas pelo MMA envolve a ativação do receptor NMDA. O envolvimento GABAérg
Publicado em: 2007