Nitric Oxide Adverse Effects
Mostrando 1-12 de 22 artigos, teses e dissertações.
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1. Design, synthesis, biological evaluation, and nitric-oxide release studies of a novel series of celecoxib prodrugs possessing a nitric-oxide donor moiety
A new group of hybrid nitric oxide-releasing anti-inflammatory drugs (NONO-coxibs), in which an O 2-acetoxymethyl-1-(N-ethyl-N-methylamino)diazen-1-ium-1,2-diolate NO-donor moiety is attached directly to the carboxylic acid group of 1-(4-aminosulfonylphenyl)-5-aryl-1H-pyrazol-3-carboxylic acids (6a-c), were synthesized. A low amount of NO was released from t
Braz. J. Pharm. Sci.. Publicado em: 08/04/2019
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2. Nitric oxide reduces oxidative damage induced by water stress in sunflower plants
Drought is one of the main environmental constraints that can reduce plant yield. Nitric oxide (NO) is a signal molecule involved in plant responses to several environmental stresses. The objective of this study was to investigate the cytoprotective effect of a single foliar application of 0, 1, 10 or 100 µM of the NO donor sodium nitroprusside (SNP) in sun
Bragantia. Publicado em: 2015-04
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3. Estudo translacional sobre a qualidade do cuidado materno em resposta ao estresse neonatal, sua associação com ansiedade na vida adulta e investigação de potenciais mecanismos envolvidos
Introduction: In humans, there is the suggestion that an adverse early life environment is related to the development of anxiety disorders in adulthood. This association could potentially be mediated by stress responses, brain-derived neurotrophic factor (BDNF) and by neuronal nitric oxide synthase (nNOS). This study aimed at proposing an animal model for th
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 2011
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4. Blockade of the action of nitric oxide in human septic shock increases systemic vascular resistance and has detrimental effects on pulmonary function after a short infusion of methylene blue
To investigate the role of nitric oxide in human sepsis, ten patients with severe septic shock requiring vasoactive drug therapy and mechanical ventilation were enrolled in a prospective, open, non-randomized clinical trial to study the acute effects of methylene blue, an inhibitor of guanylate cyclase. Hemodynamic and metabolic variables were measured befor
Publicado em: 2010
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5. Rosiglitazona, agonista do PPAR-y "Peroxisome Proliferator-Activated Receptor-y" reverte a nefrotoxicidade induzida pelo tenofovir-DF / The peroxisome proliferator-activated receptor-y agonist rosiglitazone reverses tenofovir-induced nephrotoxicity
Objective: To characterize the mechanisms of tenofovir disoproxil fumarate (TDF)- induced nephrotoxicity and the protective effects of rosiglitazone (RSG), a peroxisome proliferator-activated receptor-y agonist. Methods: Rats were treated for 30 days with one of two TDF doses (50 or 300 mg/kg of food), to which RSG (92 mg/kg of food) was added for the last 1
Publicado em: 2008
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6. O óxido nítrico e sua relação com diferentes microrganismos in vitro e durante a infecção aguda experimental por Trypanosoma cruzi / Nitric oxide and its relationship with different microorganisms in vitro and during experimental acute infection with Trypanosoma cruzi
O óxido nítrico (NO) é um radical livre gerado a partir da L-arginina, através da enzima oxido nítrico sintase (NOS). O NO é considerado um dos principais mediadores de citotoxicidade produzido por células da resposta imune, principalmente macrófagos (MØs), contra diversos microorganismos invasores. Embora, muitos trabalhos ressaltem a capacidade de
Publicado em: 2008
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7. Exposição aguda ao material particulado total em suspensão proveniente de diferentes fontes e suas repercussões nas respostas inflamatórias, sistêmica e local, em ratos / Acute exposure to total suspended particles from different sources and their impacts on both systemic and local inflammatory responses in rats
Background: Air pollution is associated with both increased morbidity and mortality. These associations persist even at lower concentrations and shortterm exposure. Objectives: To assess the impact of the components of three different sources of Total Suspended Particles (TSP) on local and systemic inflammatory responses in healthy rats. Methods: TSP from au
Publicado em: 2007
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8. Influência do óxido nítrico na cicatrização da esofagite erosiva em fumantes / Influence of nitric oxide on healing of erosive esophagitis in smokers
INTRODUÇÃO: O cigarro é citado como um possível fator externo que influencia sobre a fisiopatologia e a evolução da doença do refluxo gastroesofágico (DRGE). O cigarro contém uma quantidade significativa de óxido nítrico (NO). Os objetivos deste trabalho foram avaliar, em pacientes fumantes com DRGE erosiva, o papel do NO, pela análise de seus pr
Publicado em: 2007
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9. "Determinantes funcionais e morfológicos de ação de droga sobre os pulmões utilizando um modelo experimental em cobaias sob uso do cloridrato de fluoxetina" / Functional and morphological determinants of drug action on the lungs through an experimental model in guinea pigs under use of fluoxetine
Muito se tem pesquisado sobre os efeitos adversos dos antidepressivos tricíclicos (p.e. imipramina) sobre o sistema respiratório, embora pouco ou quase nada se encontre com relação a tal aspecto na literatura médica sobre a fluoxetina (Prozac®) um inibidor seletivo da recaptação de serotonina, até porque esta droga começou a ser utilizada somente
Publicado em: 2005
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10. Estudo dos mecanismos envolvidos na redução da sensibilidade à insulina decorrente da restrição crônica de sal: o sistema nervoso simpático e a via 1-arginina - óxido nítrico / Study of the mechanisms of the lower insulin sensitivity due to chronic salt restriction: the sympathetic nervous system and the l-arginine - nitric oxide pathway
A restrição crônica de sal na dieta tem sido recomendada como medida não medicamentosa do tratamento da hipertensão arterial sistêmica. Entre os efeitos observados desta medida terapêutica tem sido descrita uma redução dos valores da pressão arterial (PA), tanto em indivíduos normotensos e pacientes hipertensos, assim como em animais de laboratór
Publicado em: 2003
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11. Estudo dos efeitos da inibiÃÃo crÃnica do Ãxido nÃtrico na reproduÃÃo de ratos machos / Study of the effect of the chronic inhibition of nitric oxide in the reproduction of male rats
Nitric Oxide (NO) derived from L-arginine by the nitric oxide synthase (NOS) which is expressed by various isoforms, is considered to be na important messenger molecule in several organ systems including the male genital tract. This study analysed the possible effects of L-NAME (NG-nitro-L-arginine methyl ester), a nonselective NOS inhibitor on testicilar de
Publicado em: 2002
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12. Efficacy of treatment with the iron (III) complex of diethylenetriamine pentaacetic acid in mice and primates inoculated with live lethal dose 100 Escherichia coli.
The iron (III) complex of diethylenetriamine pentaacetic acid (DTPA iron [III]) protected mice and baboons from the lethal effects of an infusion with live LD100 Escherichia coli. In mice, optimal results were obtained when DTPA iron (III) was administered two or more hours after infection. Prevention of death occurred in spite of the fact that the adverse e