Nimodipine
Mostrando 1-12 de 47 artigos, teses e dissertações.
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1. Efficacy of nimodipine in the treatment of subarachnoid hemorrhage: a meta-analysis
Resumo Antecedentes Hemorragia subaracnóidea (SAH) é um subtipo raro e grave de acidente vascular cerebral (AVC), o que leva à perda da capacidade do paciente de produzir e viver por muitos anos. Objetivo Investigar o efeito clínico da nimodipina no tratamento da SAH. Métodos As bases de dados eletrônicas, incluindo a China National Knowledge Infras
Arquivos de Neuro-Psiquiatria. Publicado em: 2022
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2. Analgesic effects of Marasmius androsaceus mycelia ethanol extract and possible mechanisms in mice
Marasmius androsaceus is a medicinal fungus mainly used to treat various forms of pain in China. This study investigated the analgesic effects of an ethanol extract of M. androsaceus (MAE) and its potential molecular mechanisms. Oral administration of MAE (50, 200, and 1000 mg/kg) had significant analgesic effects in an acid-induced writhing test, a formalin
Braz J Med Biol Res. Publicado em: 01/03/2018
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3. Using fluid bed granulation to improve the dissolution of poorly water-soluble drugs
In this study, fluid bed granulation was applied to improve the dissolution of nimodipine and spironolactone, two very poorly water-soluble drugs. Granules were obtained with different amounts of sodium dodecyl sulfate and croscarmellose sodium and then compressed into tablets. The dissolution behavior of the tablets was studied by comparing their dissolutio
Brazilian Archives of Biology and Technology. Publicado em: 2012-06
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4. Investigation into in vitro anti-leishmanial combinations of calcium channel blockers and current anti-leishmanial drugs
The need for drug combinations to treat visceral leishmaniasis (VL) arose because of resistance to antimonials, the toxicity of current treatments and the length of the course of therapy. Calcium channel blockers (CCBs) have shown anti-leishmanial activity; therefore their use in combination with standard drugs could provide new alternatives for the treatmen
Memórias do Instituto Oswaldo Cruz. Publicado em: 2011-12
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5. Determination of nimodipine in plasma by HPLC-MS/MS and pharmacokinetic application
Um método rápido, específico e sensível para quantificar nimodipino em plasma humano usando dibucaína como padrão interno (IS) é descrito. O analito e o IS foram extraídos das amostras de plasma por extração líquido-líquido usando hexano-acetato de etila (1:1 v/v). A separação cromatográfica foi realizada utilizando-se uma coluna analítica C1
Brazilian Journal of Pharmaceutical Sciences. Publicado em: 2010-12
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6. Development and characterization of nimodipine solid dispersions of PEG 6000 or Poloxamer 407 / Desenvolvimento e caracterização de dispersões sólidas de nimodipino empregando PEG 6000 ou Poloxamer 407
Nimodipine is a calcium blocker, used in prevention and treatment of ischaemic neurological deficits after aneurismal subarachnoid hemorrhage and cognitive deficit. It exhibits a low solubility in water and it is classified as class two in the Biopharmaceutics Classification System (BCS), thereby dissolution is the ratelimiting step in absorption, which impa
Publicado em: 2010
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7. Efeitos pré e pós sinápticos dos inibidores da acetilcolinesterase na neurotransmissão em musculatura lisa.
Justification: The present work considers the effects of new inhibitors of acetylcholinesterase (AChE) on the reactivity and neurotransmission in rats and mice. The new anticholinesterase compounds, ITH12118 and ITH12117, have an hybrid stucture, derived from the molecule of of the anticholinesterase Tacrine and the 1,4 dihydropyridine nimodipine, a blocker
Publicado em: 2010
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8. Studies of seizures and actions of nimodipine on pilocarpine-induced seizures in young rats. / Estudo do processo convulsivo e das ações da nimodipina no modelo de convulsão com pilocarpina em ratos jovens
Behavioral and neurochemical studies were carried out with 21 days-old rats pretreated or not with nimodipine (10 or 30mg/Kg, i.p.) on pilocarpine-induced seizures (400mg/Kg, s.c.) to investigate the mechanism involved in the acute phase of seizures and the effects of nimodipine on seizures. The behavioral studies showed peripheral cholinergic signs, stereot
Publicado em: 2005
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9. Estudo de biodisponibilidade relativa de duas formulações de felodipina em plasma humano utilizando cromatografia liquida acoplada a espectrometria de massas
A rapid, sensitive,robust and specificmethodwas developed for the determinationand quantitation of felodipine, in human blood plasma by liquid chromatography coupled with tandem mass spectrometryusing nimodipine as internalstandardoFelodipinewas extractedfrom 0.5mL human plasma by use of a liquid/liquidprocedureusing diethyIetherlhexane(80/20:v/v) as eluent.
Publicado em: 2005
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10. Nimodipine determination in human plasma by high-performance liquid chromatography coupled to tandem mass spectrometry (HPLC-MS-MS). / Determinação de nimodipino em plasma humano através de cromatografia líquida de alta eficiência acoplada à espectrometria de massa (LC-MS-MS)
Um método rápido, sensível e específico de Cromatografia Líquida de Alta Eficiência acoplada à Espectrometria de Massa (LC-MS-MS) foi desenvolvido para determinar nimodipino (analito) em plasma humano usando dibucaína como padrão interno (PI). O analito (m/z 418,6 >342,6) e o PI (m/z 344,2 >271,0) foram extraídos de amostras de plasma através de e
Publicado em: 2005
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11. Estudos de bioequivalencia de duas formulações comerciais de Nimodipina e Ambodipina
Objectíve: This thesis had as objective to evaluate the bioequivalence through the pharmacokinetic and pharmacodynamic of two comercial formulations of two Calcium Blockers, Amlodipine (Biosintética CordareneR tablets 5 mg vs Pfizer NorvascR tablets 5 mg) and Nimodipine (Biosintética OxigenR tablets 90 mg vs Bayer NimotopR tablets 90 mg). It was selected
Publicado em: 1997
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12. Experimental intracerebral haemorrhage: the effect of nimodipine pretreatment.
The effect of pretreatment with the calcium antagonist nimodipine on the pathophysiological events which follow an intracerebral haemorrhage in rats was compared with a similar control group. Cerebral blood flow was higher and the amount of pathologically determined ischaemic damage measured by light microscopy was less in the nimodipine pretreated group. Bl