Neuroprotection
Mostrando 13-24 de 163 artigos, teses e dissertações.
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13. Combination vitamin C and vitamin E prevents enteric diabetic neuropathy in the small intestine in rats
The present study evaluated the effects of supplementation with a combination of vitamin C and vitamin E on NADH-diaphorase-positive (NADH-d+) and neuronal nitric oxide synthase (nNOS)-immunoreactive myenteric neurons in the duodenum and ileum in diabetic rats. Forty rats were distributed into the following groups: normoglycemic (N), normoglycemic supplement
Braz. arch. biol. technol.. Publicado em: 01/05/2015
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14. The role of necroptosis in neurosurgical diseases
Programmed necrosis or necroptosis is an alternative form of cell death that is executed through a caspase-independent pathway. Necroptosis has been implicated in many pathological conditions. Genetic or pharmacological inhibition of necroptotic signaling has been shown to confer neuroprotection after traumatic and ischemic brain injury. Therefore, the necro
Braz J Med Biol Res. Publicado em: 24/02/2015
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15. A forced running wheel system with a microcontroller that provides high-intensity exercise training in an animal ischemic stroke model
We developed a forced non-electric-shock running wheel (FNESRW) system that provides rats with high-intensity exercise training using automatic exercise training patterns that are controlled by a microcontroller. The proposed system successfully makes a breakthrough in the traditional motorized running wheel to allow rats to perform high-intensity training a
Braz J Med Biol Res. Publicado em: 15/08/2014
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16. ERKs and mitochondria-related pathways are essential for glycyrrhizic acid-mediated neuroprotection against glutamate-induced toxicity in differentiated PC12 cells
The present study focuses on the neuroprotective effect of glycyrrhizic acid (GA, a major compound separated from Glycyrrhiza Radix, which is a crude Chinese traditional drug) against glutamate-induced cytotoxicity in differentiated PC12 (DPC12) cells. The results showed that GA treatment improved cell viability and ameliorated abnormal glutamate-induced alt
Braz J Med Biol Res. Publicado em: 25/07/2014
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17. Sympathetic glial cells and macrophages develop different responses to Trypanosoma cruzi infection or lipopolysaccharide stimulation
Nitric oxide (NO) participates in neuronal lesions in the digestive form of Chagas disease and the proximity of parasitised glial cells and neurons in damaged myenteric ganglia is a frequent finding. Glial cells have crucial roles in many neuropathological situations and are potential sources of NO. Here, we investigate peripheral glial cell response to Tryp
Mem. Inst. Oswaldo Cruz. Publicado em: 2014-07
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18. Neuroprotection of Persea major extract against oxygen and glucose deprivation in hippocampal slices involves increased glutamate uptake and modulation of A1 and A2A adenosine receptors
Ischemic stroke is characterised by a lack of oxygen and glucose in the brain, leading to excessive glutamate release and neuronal cell death. Adenosine is produced in response to ATP depletion and acts as an endogenous neuromodulator that reduces excitotoxicity. Persea major (Meins.) L.E. Kopp (Lauraceae) is a medical plant that is indigenous to South Brazi
Rev. bras. farmacogn.. Publicado em: 2013-10
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19. Ischemia preconditioning is neuroprotective in a rat cerebral ischemic injury model through autophagy activation and apoptosis inhibition
Sublethal ischemic preconditioning (IPC) is a powerful inducer of ischemic brain tolerance. However, its underlying mechanisms are still not well understood. In this study, we chose four different IPC paradigms, namely 5 min (5 min duration), 5×5 min (5 min duration, 2 episodes, 15-min interval), 5×5×5 min (5 min duration, 3 episodes, 15-min intervals), a
Braz J Med Biol Res. Publicado em: 16/07/2013
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20. A metanandamida, um agonista canabinóide, protege a linhagem de neuroblastoma neuro2A da morte celular induzida por peróxido de hidrogênio. / The methanandamide, a cannabinoid agonist, protect the lineage of neuro 2A cell death induced by hydrogen peroxide.
Neurodegenerative diseases are progressive disorder affecting specific neuronal populations in the central nervous system, leading to neuronal death. Several factors contribute to the development of neurodegenerative diseases, including increased free radical formation and / or oxidative stress. The cannabinoid system has been suggested as an important syste
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 02/07/2012
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21. Exercício físico em idosos: efeito nos biomarcadores periféricos de neuroproteção / Physical activity in elderly: effect on peripheral biomarker of neuroprotection GSK3
The physical activity (PA) was demonstrated to have a protective effect against Alzheimers disease, but the influence of exercising on the biomarker of neuroprotection such as Glycogen synthase kinase 3 (GSK-3) are hitherto imprecise. This study aims at assessing the effect of PA on the serum levels of GSK3. We have performed a cross-sectional observational
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 23/05/2012
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22. Avaliação da atividade neuroprotetora da Parawixina 11 isolada da peçonha da aranha Parawixia bistriata (Araneae, Araneidae), em ratos Wistar submetidos a um modelo de glaucoma agudo / Neuroprotective activity analysis of Parawixin 11, isolated from Parawixia bistriata (Araneae, Araneidae) spider venom, in Wistar rats submitted to an model of acute glaucoma
Glaucoma is defined as a typical optic neuropathy characterized by ganglion cells loss and consequent optic nerve damage, resulting in a gradual reduction of the visual field and eventual blindness. In regard to compounds present in spider venoms, they represent an interesting source of bioactive molecules and the study about the possible neuroprotective eff
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 27/04/2012
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23. ATIVIDADE ANTIOXIDANTE in vitro DO EXTRATO ETANÓLICO DAS FOLHAS DE Luehea divaricata Mart. / In vitro ANTIOXIDANT ACTIVITY OF THE ETHANOLIC EXTRACT OF Luehea divaricata Mart. LEAVES
O estresse oxidativo tem sido relacionado a algumas desordens neurodegenerativas. As terapias atuais para essas doenças estão limitadas a atenuar os sintomas apresentados, entretanto alguns estudos têm mostrado que compostos antioxidantes podem ser capazes de prevenir ou retardar o dano oxidativo neuronal, incluindo aqueles presentes em extratos vegetais.
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 16/03/2012
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24. NAA and NAAG variation in neuronal activation during visual stimulation
N-acetyl-aspartyl-glutamate (NAAG) and its hydrolysis product N-acetyl-L-aspartate (NAA) are among the most important brain metabolites. NAA is a marker of neuron integrity and viability, while NAAG modulates glutamate release and may have a role in neuroprotection and synaptic plasticity. Investigating on a quantitative basis the role of these metabolites i
Braz J Med Biol Res. Publicado em: 2012-11