Neurogenesis
Mostrando 1-12 de 270 artigos, teses e dissertações.
-
1. Anxiolytic-like and proneurogenic effects of Trichilia catigua ethyl-acetate fraction in mice with cerebral ischemia
Abstract Trichilia catigua A. Juss., Meliaceae, known as "catuaba" in Brazil, has been popularly used as a tonic for fatigue, impotence and memory deficits. Previously, we have demonstrated that T. catigua ethyl-acetate fraction exerted antidepressive-like effects in mice. Affective-like symptoms are also well recognized outcome of cerebral ischemia in clini
Rev. bras. farmacogn.. Publicado em: 09/12/2019
-
2. Efficacy of adjunctive Garcinia mangostana Linn (mangosteen) pericarp for bipolar depression: study protocol for a proof-of-concept trial
Objective: Bipolar depression is characterized by neurobiological features including perturbed oxidative biology, reduction in antioxidant levels, and a concomitant rise in oxidative stress markers. Bipolar depression manifests systemic inflammation, mitochondrial dysfunction, and changes in brain growth factors. The depressive phase of the disorder is the
Braz. J. Psychiatry.. Publicado em: 11/10/2018
-
3. Deformation of Mitochondrial Cristae in Human Neural Progenitor Cells Exposed to Valproic Acid
ABSTRACT Neural development represents a dynamic process where mitochondrial integrity is decisive for neuronal activity. Structural changes in these organelles may be related to neurological disorders. Valproic acid (VPA) is an anticonvulsive drug commonly used for epilepsy treatment and its use is associated to increased risk of neuropsychiatric disorders.
An. Acad. Bras. Ciênc.. Publicado em: 23/04/2018
-
4. Cystometric analysis of the transplanted bladder
ABSTRACT Objective Cystometric evaluation of the bladder after autotransplant and isogeneic transplant in female rats. Material and Methods Two groups were constituted: (A) bladder autotransplant with two subgroups: R1 – (control) and R2 – (bladder transplant); (B) isogeneic bladder transplant with three subgroups; T1 – (control); T2–T3, two subg
Int. braz j urol.. Publicado em: 2017-02
-
5. Mapeamento de potencial nicho neurogênico no lobo temporal humano
The subgranular zone (SGZ) of the dentate gyrus and the subventricular zone (SVZ) are known neurogenic niches in adult mammals. Nonetheless, the existence of neurogenic niches in adult humans is controversial. We hypothesized that mapping neurogenic niches in the human temporal lobe could clarify this issue. Neurogenic niches and neurogenesis were investigat
Arq. Neuro-Psiquiatr.. Publicado em: 2014-10
-
6. Papel da neurogênese nos efeitos promnésicos do ambiente enriquecido sobre a memória social
Social memory comprehends the information necessary to identify and recognize co-specifics. This kind of memory is essential in many forms of social interaction and is modulated by the environmental conditions. Previous studies from our laboratory showed that social isolation impairs the social memory persistence and that enriched environment (EE) prevents t
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 29/03/2012
-
7. Linking dopamine neurotransmission and neurogenesis: the evolutionary history of the NTAD (NCAM1-TTC12-ANKK1-DRD2) gene cluster
Genetic studies have long suggested the important role of the DRD2 gene in psychiatric disorders and behavior. Further research has shown a conjoined effect of genes in the Chr11q22-23 region, which includes the NCAM1, TTC12, ANKK1 and DRD2 genes, or NTAD cluster. Despite a growing need to unravel the role of this cluster, few studies have taken into account
Genet. Mol. Biol.. Publicado em: 2012
-
8. Modelo de múltiplas escalas para a dinâmica de crescimento de estruturas biológicas ramificadas / Multiscale model for the dynamics of growth of biological branching structures
The characterization of fractals and the search for general rules and mechanisms for description of non-linear phenomena brought the attention of the scientific community to the interdisciplinary area of complex systems. Complex phenomena can be found in almost every branch of natural science. One example is the simulation using cellular automata of self-org
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 22/07/2011
-
9. Efeito da inibição da enzima JAK2 sobre a morte neuronal, astrogliose e neurogênese no estriado de camundongos adultos após injeção unilateral de ácido quinolínico / Effect of JAK2 enzyme inhibition on neuronal death, astrogliosis and neurogenesis in the striatum of adult mice after unilateral injection of quinolinic acid
A injeção de ácido quinolínico (AQ), um agonista glutamatérgico do receptor N-metil-D-aspartato, no estriado de roedores induz morte seletiva de neurônios espinhosos médios, gliose reativa e neurogênese na zona subventricular, acompanhada da migração dos neurônios recém-gerados para o estriado lesado. Tais achados são também descritos na doenç
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 22/06/2011
-
10. Mutações inativadoras dos genes PROK2 e PROKR2 em pacientes com hipogonadismo hipogonadotrófico isolado / PROK2 and PROKR2 inactivating mutations in patients with idiopathic hypogonadotropic hypogonadism
O sistema da procineticina desempenha um papel importante na migração dos neurônios secretores de GnRH e na neurogênese do bulbo olfatório. Camundongos com ablação dos genes que codificam a procineticina 2 (PROK2) e seu receptor (PROKR2) apresentaram fenótipos semelhantes ao da síndrome de Kallmann descrita em humanos. Mutações inativadoras nos ge
Publicado em: 2011
-
11. Quantification of microRNAs in the central nervous system : implications / Quantificação de diferentes microRNAs no sistema nervoso central : implicações nos mecanismos de desenvolvimento e processos fisiopatologicos
MicroRNAs are a new class of small RNA molecules (21-24 nucleotide-long) that negatively regulate gene expression either by translational repression or target mRNA degradation. It is believed that about 30% of all human genes are targeted by these molecules. MiRNAs are involved in many important biological processes including cell differentiation, embryonic
Publicado em: 2010
-
12. Glutamate-N-methyl-D-aspartate receptor modulation and minocycline for the treatment of patients with schizophrenia: an update
Growing consistent evidence indicates that hypofunction of N-methyl-D-aspartate (NMDA) transmission plays a pivotal role in the neuropathophysiology of schizophrenia. Hence, drugs which modulate NMDA neurotransmission are promising approaches to the treatment of schizophrenia. The aim of this article is to review clinical trials with novel compounds acting o
Brazilian Journal of Medical and Biological Research. Publicado em: 2009-11