Neoplastic Stem Cells
Mostrando 1-12 de 30 artigos, teses e dissertações.
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1. CD47 expression is decreased in hematopoietic progenitor cells in patients with myelofibrosis
Myelofibrosis (MF) is characterized by increased circulating hematopoietic progenitor cells (HPCs), abnormal cytokine levels, and the survival advantage of neoplastic progenitors over their normal counterparts, which leads to progressive disappearance of polyclonal hematopoiesis. CD47 is a surface glycoprotein with many functions, such as acting as a phagocy
Braz J Med Biol Res. Publicado em: 10/12/2018
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2. Expression of CD90 and P75NTR stem cell markers in ameloblastomas: a possible role in their biological behavior
Abstract Multicystic and unicystic ameloblastomas are benign odontogenic tumors that present distinct biological behavior. The investigation of stem cells has become an important branch of tumor biology, with several studies addressing the possible role of these cells in tumor growth, angiogenesis, progression, infiltration and invasiveness. This study evalu
Braz. oral res.. Publicado em: 10/10/2016
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3. Obesity and inflammation and the effect on the hematopoietic system
Bone marrow is organized in specialized microenvironments known as 'marrow niches'. These are important for the maintenance of stem cells and their hematopoietic progenitors whose homeostasis also depends on other cell types present in the tissue. Extrinsic factors, such as infection and inflammatory states, may affect this system by causing cytokine dysregu
Rev. Bras. Hematol. Hemoter.. Publicado em: 2014-04
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4. Angiogênese, células-tronco neoplásicas CD34+ e sinvastatina em modelo de carcinogênese mamária induzida quimicamente / Angiogenesis, CD34+ cancer stem-cells and simvastatin in a chemically induced mammary carcinogenesis model
Breast cancer is the most common malignancy and the leading cause of death from cancer among females worldwide. Despite all the research and all the progress achieved so far, the morbidity and mortality due to this cancer remains high in patients at advanced stages. Recently, it was described a new model of carcinogenesis in which stem cells (SC) could be re
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 20/02/2012
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5. Molecular biology of Philadelphia-negative myeloproliferative neoplasms
Myeloproliferative neoplasms are clonal diseases of hematopoietic stem cells characterized by myeloid hyperplasia and increased risk of developing acute myeloid leukemia. Myeloproliferative neoplasms are caused, as any other malignancy, by genetic defects that culminate in the neoplastic phenotype. In the past six years, since the identification of JAK2V617F
Revista Brasileira de Hematologia e Hemoterapia. Publicado em: 2012
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6. Expressão de CD44 e CD24 em carcinomas mamários ductais invasivos de acordo com análise dos subtipos moleculares e sua relação com fatores prognósticos / CD44 and CD24 expression in ductal invasive breast carcinomas, classified by molecular subtypes and its association with prognostic factors
Carcinomas de mama são heterogêneos e consistem de diversos tipos celulares. Perfis de expressão gênica usando DNA microarrays identificaram quatro subtipos moleculares fundamentais baseados na expressão de receptores hormonais (estrógeno e progesterona) e de fator de crescimento epidérmico (HER2) (luminal tipo A, luminal tipo B, tumores expressando s
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 15/09/2011
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7. Análises citogenéticas e expressão da telomerase em sarcoma 180
The cancer is a result of genetic instability. There are two theorical lines which try to explain this pathology origin, the conventional genetic theories and the chromosomal theory of cancer. A lot of neoplastic cell characteristics cant be explained by the conventional theories and they are explained by the chromosomal theory. The telomerase plays an impor
Publicado em: 2008
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8. ROLE OF Bcl-2 AND Bcl-XL IN ANGIOGENESIS
(...)Angiogenesis is defined as the development of new capillaries from pre-existing blood vessels. The hypothesis that tumor growth is angiogenesis dependent was proposed by Judah Folkman in 1971, and it has been confirmed by many investigators thereafter. We have shown that vascular endothelial growth factor (VEGF) induces Bcl-2 expression in endothelial c
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 2006
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9. Turning Cancer Stem Cells Inside Out: An Exploration of Glioma Stem Cell Signaling Pathways*
Tumors are complex collections of heterogeneous cells with recruited vasculature, inflammatory cells, and stromal elements. Neoplastic cells frequently display a hierarchy in differentiation status. Recent studies suggest that brain tumors have a limited population of neoplastic cells called cancer stem cells with the capacity for sustained self-renewal and
American Society for Biochemistry and Molecular Biology.
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10. Mastocytosis: reactive or neoplastic?
Mast cells are now known to derive from CD34+ haemopoietic stem cells in the bone marrow. However, it has not yet been established whether the various types of mastocytosis, which involve tumour-like proliferation of mast cells, are true neoplastic disorders or reactive/hyperplastic conditions. In this study, tissue specimens (five bone marrow, two spleen, o
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11. Very Small Embryonic/Epiblast-Like Stem Cells : A Missing Link To Support the Germ Line Hypothesis of Cancer Development?
The morphology of several tumors mimics developmentally early tissues, and tumors often express early developmental markers characteristic of the germ line lineage. The presence of these markers in neoplastic cells could reflect the dedifferentiation of somatic cells in which cancer develops or cancer origination in primitive stem cells closely related to th
American Society for Investigative Pathology.
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12. Unregulated proliferation of primitive chronic myeloid leukemia progenitors in the presence of normal marrow adherent cells.
Previous studies have shown that Philadelphia (Ph1) chromosome-positive chronic myeloid leukemia (CML) results from the abnormal expansion at the pluripotent stem cell level of a single clone of hemopoietic cells. Although it seems likely that this is related to the heightened proliferative activity characteristic of primitive CML progenitor cell types, the