N Acylhydrazone
Mostrando 1-8 de 8 artigos, teses e dissertações.
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1. PREPARAÇÃO DE HIDRAZONA E N-ACILIDRAZONA USANDO FÁRMACOS COMERCIAIS COMO REAGENTES: AULAS PRÁTICAS DE SÍNTESE DE COMPOSTOS BIOATIVOS
Several scientific works demonstrate the chemical and medicinal importance of hydrazone compounds. In this regard, the present paper proposes some practical classes of chemoinformatics and organic chemistry, using investigative and illustrative strategies, to teach the synthesis of a hydrazone and a N-acylhydrazone with proven biological activity. The motiva
Quím. Nova. Publicado em: 2020-05
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2. Synthesis, X-ray diffraction study and pharmacological evaluation of 3-amino-4-methylthiophene-2-acylcarbohydrazones
ABSTRACT N-acylhydrazone is an interesting privileged structure that has been used in the molecular design of a myriad of bioactive compounds. In order to identify new antinociceptive drug candidates, we described herein the design, synthesis, X-ray diffraction study and the pharmacological evaluation of a series of 3-amino-4-methylthiophene-2-acylcarbohydra
An. Acad. Bras. Ciênc.. Publicado em: 2018
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3. Crystal Structures of 1-Aryl-1H- and 2-Aryl-2H-1,2,3-triazolyl Hydrazones. Conformational Consequences of Different Classical Hydrogen Bonds
The crystal structures of (Z)-1-phenyl-4-[((2-phenylhydrazono)methyl)]-1H-1,2,3-triazole, (Z)-4-[(2-(2,4-dimethylphenyl)hydrazono)methyl]-2-phenyl-2H-1,2,3-triazole, (E)-4-[(2-(2,4-dinitrophenyl)hydrazono)methyl]-2-phenyl-2H-1,2,3-triazole, and (E)-N'-((2-phenyl-2H-1,2,3-triazol-4-yl)methylene)isonicotinohydrazide dihydrate are reported. The formations of (Z
J. Braz. Chem. Soc.. Publicado em: 2016-12
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4. Impairment of locomotor activity induced by the novelN-acylhydrazone derivatives LASSBio-785 and LASSBio-786 in mice
The N-acylhydrazone (NAH) analogues N-methyl 2-thienylidene 3,4-benzoylhydrazine (LASSBio-785) and N-benzyl 2-thienylidene 3,4-benzoylhydrazine (LASSBio-786) were prepared from 2-thienylidene 3,4-methylenedioxybenzoylhydrazine (LASSBio-294). The ability of LASSBio-785 and LASSBio-786 to decrease central nervous system activity was investigated in male Swiss
Braz J Med Biol Res. Publicado em: 19/03/2013
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5. Síntese e avaliação preliminar da atividade antibacteriana e antifúngica de derivados N-acilidrazônicos
We describe the synthesis and evaluation of N-acylhydrazone compounds bearing different electron-donating groups in one of its aromatic rings, obtained using a four-step synthetic route. IC50 values against pathogenic fungi and bacteria were determined by serial microdilution. Compounds showed low activity against Staphylococcus aureus, Escherichia coli and
Quím. Nova. Publicado em: 2012
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6. Análise conformacional de derivados n-acilidrazona em solvente aquoso
O grupamento N-acilidrazona (NAH) constitui um grupo farmacofórico devido sua relação com uma série de atividades biológicas dentre as quais se destacam, mas não se limitam a estas, as atividades cardioativa, antiinflamatória e analgésica. Com base nessa relevância biológica este trabalho versará sobre a avaliação do perfil conformacional de alg
Publicado em: 2009
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7. Estratégia de simplificação molecular no planejamento racional de fármacos: a descoberta de novo agente cardioativo
In this article are described examples of the successful use of molecular simplification strategy in the discovery of new drugs from bioactive natural products and synthetic compounds. The discovery of a new cardiotonic derivative (37, 2-thienylidene-3,4-methylenedioxybenzoylhydrazine; LASSBio-294), efficiently synthesized from Brazilian natural product and
Química Nova. Publicado em: 2002-12
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8. A química medicinal de N-acilidrazonas: novos compostos-protótipos de fármacos analgésicos, antiinflamatórios e anti-trombóticos
In this article are described new bioactive N-acylhydrazone (NAH) derivatives, structurally designed as optimization of aryl hydrazones precursors planned by molecular hybridization of two 5-lipoxigenase inhibitors, e.g. CBS-1108 and BW-755c. The analgesic, antiedematogenic and anti-platelet aggregating profile of several isosteric compounds was investigated
Química Nova. Publicado em: 2002-02