N Acetyl L Cysteine
Mostrando 1-12 de 127 artigos, teses e dissertações.
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1. ESTUDO TEÓRICO E EXPERIMENTAL DE ESTRUTURA E REATIVIDADE RELACIONADO AO METABOLISMO E TOXICIDADE DO PARACETAMOL
An experimental and theoretical approach on oxidative metabolism of paracetamol was applied for the pharmaceutical chemistry learning. Classical reactions, functional group identification, structural parameter, and chemical reactivity using frontier orbitals and Fukui index were used explaining the main products between N-acetyl-p-benzosemiquinone (NAPQI) an
Química Nova. Publicado em: 2022
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2. β-Hydroxyisovalerylshikonin promotes reactive oxygen species production in HCT116 colon cancer cells, leading to caspase-mediated apoptosis
ABSTRACT Although β-hydroxyisovalerylshikonin is suggested as a potential therapeutic agent for preventing various cancers, the underlying molecular mechanisms are not completely understood. In the present study, we investigated whether β-hydroxyisovalerylshikonin enhances apoptosis by triggering reactive oxygen species production in colon cancer HCT116 ce
Rev. bras. farmacogn.. Publicado em: 2018-06
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3. N-Acetyl-cysteine Increases Chemical Stability of Hydroquinone in Pharmaceutical Formulations: a Theoretical and Experimental Approach
In this study, the chemistry stability of hydroquinone (HQ) was evaluated according to its effects in redox properties and compared to kojic acid (KA). The HQ oxidation was more inhibited by N-acetylcysteine (NAC) than ascorbic acid (AA). These results were elucidated using theoretical methods at the DFT/B3LYP level of theory. All electronic parameters were
J. Braz. Chem. Soc.. Publicado em: 2018-03
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4. Protective effects of deferasirox and N-acetyl-L-cysteine on iron overload-injured bone marrow
Using an iron overload mouse model, we explored the protective effect of deferasirox (DFX) and N-acetyl-L-cysteine (NAC) on injured bone marrow hematopoietic stem/progenitor cells (HSPC) induced by iron overload. Mice were intraperitoneally injected with 25 mg iron dextran every 3 days for 4 weeks to establish an iron overload (Fe) model. DFX or NAC were co-
Braz J Med Biol Res. Publicado em: 19/10/2017
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5. N-acetyl-cysteine inhibits liver oxidative stress markers in BALB/c mice infected with Leishmania amazonensis
BACKGROUND Leishmaniasis is a parasitosis caused by several species of the genus Leishmania. These parasites present high resistance against oxidative stress generated by inflammatory cells. OBJECTIVES To investigate oxidative stress and molecular inflammatory markers in BALB/c mice infected with L. amazonensis and the effect of antioxidant treatment on
Mem. Inst. Oswaldo Cruz. Publicado em: 2017-02
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6. Lifespan extension and increased resistance to environmental stressors by N-Acetyl-L-Cysteine in Caenorhabditis elegans
OBJECTIVE: This study was performed to determine the effect of N-acetyl-L-cysteine, a modified sulfur-containing amino acid that acts as a strong cellular antioxidant, on the response to environmental stressors and on aging in C. elegans. METHOD: The survival of worms under oxidative stress conditions induced by paraquat was evaluated with and without in vi
Clinics. Publicado em: 2015-05
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7. Using webcam, CdTe quantum dots and flow-batch system for automatic spectrofluorimetric determination of N-Acetyl-L-cysteine in pharmaceutical formulations
Neste trabalho é proposta a combinação de um sistema flow-batch, pontos quânticos (QDs) e de uma webcam como detector para determinação espectrofluorimétrica automática de N-acetil-L-cisteina (NAC) em formulações farmacêuticas. O NAC gera interações superficiais com os QDs, que resultam no aumento proporcional da intensidade de fluorescência co
J. Braz. Chem. Soc.. Publicado em: 2014-09
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8. AVALIAÇÃO DE NÍVEIS SÉRICOS DE PACIENTES COM LEISHMANIOSE VISCERAL TRATADOS COM N-ACETIL-L-CISTEÍNA (NAC) E ANTIMONIAL PENTAVALENTE. / EVALUATION OF SERUM LEVELS OF PATIENTS WITH VISCERAL LEISHMANIASIS TREATED WITH N-ACETYL-L-CYSTEINE (NAC) AND PENTAVALENT ANTIMONY.
Para que a quimioterapia possa resultar em cura, é importante que o sistema imune tenha condições e estímulos necessários ao desenvolvimento do perfil de citocinas adequado à resistência à doença e ao combate do agente etiológico. Estudos demonstram que o N-acetil-L-cisteína (NAC), uma substância antioxidante, contriubi para a imunoregulação de
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 20/06/2011
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9. DETERMINAÇÃO DAS CONSTANTES DE ESTABILIDADE DOS COMPLEXOS FORMADOS ENTRE OS AMINOÁCIDOS CISTEÍNA, N-ACETILCISTEÍNA E LISINA COM CHUMBO EM SOLUÇÃO AQUOSA / DETERMINATION OF STABILITY CONSTANTS FOR LEAD COMPLEXES WITH CYSTEINE, N-ACETYLCYSTEINE AND LYSINE IN AQUEOUS SOLUTIONS
In this study we investigated the interaction between lead and the amino acid cysteine, lysine and N-acetylcysteine by testing long-term contact with ion exchanger resins and also the determination of stability constants. The importance of investigating the presence of lead in solutions for parenteral nutrition is related to the risk of internal contaminatio
Publicado em: 2011
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10. Mecanismos envolvidos com a sobrevivência de Xylella fastidiosa em condições de estresse e efeito de N-Acetil-L-Cisteína em seu biofilme / Mechanisms involved in Xylella fastidiosa survival under stress conditions and effect of N-Acetyl-L-Cysteine on its biofilm
Xylella fastidiosa is a Gram-negative bacterium that causes several diseases in different plant species, including citrus variegated chlorosis (CVC) in sweet orange (Citrus sinensis L. Osbeck), whose economic damage is of millions of dollars annually. The symptoms development has been associated with the blockage of xylem vessels caused by bacterial biofilm
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 15/06/2010
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11. Role of nuclear factor kappa B and reactive oxygen species in the tumor necrosis factor-a-induced epithelial-mesenchymal transition of MCF-7 cells
The microenvironment of the tumor plays an important role in facilitating cancer progression and activating dormant cancer cells. Most tumors are infiltrated with inflammatory cells which secrete cytokines such as tumor necrosis factor-a (TNF-a). To evaluate the role of TNF-a in the development of cancer we studied its effects on cell migration with a migrat
Brazilian Journal of Medical and Biological Research. Publicado em: 2007-08
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12. Determinação indireta de N-acetil-L-cisteína por injeção em fluxo empregando Ce(IV) e ferroína
An indirect flow injection spectrophotometric procedure is proposed for the determination of N-acetyl-L-cysteine in pharmaceutical formulations. In this system, ferroin ([Fe(II)-(fen)2]2+) in excess, with a strong absorption at 500 nm, is oxidized by cerium(IV) yielding cerium(III) and [Fe(III)-(fen)2]3+ (colorless), thus producing a baseline. When N-acetyl-
Química Nova. Publicado em: 2005-10