Multi Agent
Mostrando 1-12 de 213 artigos, teses e dissertações.
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1. Activity of ceftolozane-tazobactam and comparators against gram-negative bacilli: Results from the study for monitoring antimicrobial resistance trends (SMART – Brazil; 2016–2017)
Abstract Multi-drug resistant Gram-negative bacilli (GNB) have been reported as cause of serious hospital-acquired infections worldwide. The aim of this study was to investigate the in vitro activity of ceftolozane-tazobactam compared to other agents against GNB isolated from patients admitted to Brazilian medical centers between the years 2016 and 2017. Pre
Braz J Infect Dis. Publicado em: 2020-08
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2. Calpains of Leishmania braziliensis: genome analysis, differential expression, and functional analysis
BACKGROUND Calpains are proteins belonging to the multi-gene family of calcium-dependent cysteine peptidases that undergo tight on/off regulation, and uncontrolled proteolysis of calpains is associated with severe human pathologies. Calpain orthologues are expanded and diversified in the trypanosomatids genome. OBJECTIVES Here, we characterised calpains
Mem. Inst. Oswaldo Cruz. Publicado em: 23/09/2019
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3. Construction and Evaluation of a Graphene Oxide Functionalized Aminopropyltriethoxy Silane Surface Molecularly Imprinted Polymer Potentiometric Sensor for Dipyridamole Detection in Urine and Pharmaceutical Samples
A dipyridamole (DIP) based surface molecularly imprinted polymer (MIP) was synthesized and applied as a sensing agent in a sensing layer of a new modified potentiometric carbon paste electrode (CPE). The potentiometric modified CPEs (GO@SiO2-NH2-MIP/MWCNTs/CPE, where GO is graphene oxide and MWCNTs is multi-walled carbon nanotubes) showed an improved perform
J. Braz. Chem. Soc.. Publicado em: 16/09/2019
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4. MULTI-AGENT BASED MODELING APPLIED TO PORTFOLIO SELECTION IN THE DOOM-LOOP OF SOVEREIGN DEBT CONTEXT*
ABSTRACT This study explores the self-fulfilling dynamic between sovereign debt risk and rational choices of neutral, risk-seeking and risk-averse investors, with implications to the systemic risk emergence. The agent-based model parameterization includes investment strategy (randomly selected assets, stock exchange participation, economic segment, and techn
Pesqui. Oper.. Publicado em: 09/05/2019
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5. Antimicrobial Potential of Natural and Semi-Synthetic ent-Kaurane and ent-Pimarane Diterpenes against Clinically Isolated Gram-Positive Multidrug-Resistant Bacteria
In this work, a search for antimicrobial agents against multi-drug resistant (MDR) bacteria was undertaken. It involved two natural diterpenes of different basic skeletons, named ent-kaurenoic acid and ent-pimaradienoic acid, that were used as precursors to access 28 semi-synthetic derivatives that were also submitted to biological assays. All 30 substances
J. Braz. Chem. Soc.. Publicado em: 2019-02
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6. Antimicrobial susceptibility profile of historical and recent Brazilian pig isolates of Pasteurella multocida
RESUMO: Pasteurella (P.) multocida é o agente da pasteurelose pneumônica em suínos, a qual é comumente associada com o estágio final da pneumonia enzoótica suína ou complexo das doenças respiratórias dos suínos. Apesar de ser uma das doenças mais comuns e importantes na suinocultura, dados sobre suscetibilidade antimicrobiana de isolados de P. mul
Pesq. Vet. Bras.. Publicado em: 2019-02
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7. Antibacterial activity of 3,3',4'-Trihydroxyflavone from Justicia wynaadensis against diabetic wound and urinary tract infection
ABSTRACT The present investigation was designed to study the effect of an active compound isolated from Justicia wynaadensis against multi drug resistant organisms (MDRO's) associated with diabetic patients. The drug resistant pathogens implicated in wound and urinary tract infection of diabetic patients were isolated and identified by molecular sequencing.
Braz. J. Microbiol.. Publicado em: 2018-03
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8. Impact of chrysosplenetin, per se or in combination with artemisinin, on breast cancer resistance protein (Bcrp)/ABCG2 mRNA expression levels in mice small intestine
ABSTRACT Our previous work revealed that chrysosplenetin in combination with artemisinin inhibited in vivo P-glycoprotein (P-gp, one of classic multi-drug resistance proteins) mediated digoxin transportation activity by reversing the upregulated P-gp/Mdr1 mRNA expression levels by artemisinin. Therefore, chrysosplenetin might be a potential artemisinin-resis
Rev. bras. farmacogn.. Publicado em: 2017-12
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9. Liposomes as potential carriers for ketorolac ophthalmic delivery: formulation and stability issues
ABSTRACT Drug delivery to treat ocular disorders locally is a challenging endeavor. Traditional ocular dosage form - eye drops - exhibits poor availability, consequently inefficient therapeutic response. The objective of the study was to formulate and characterize a ketorolac tromethamine ocular system with a prolonged release pattern based on liposomes as a
Braz. J. Pharm. Sci.. Publicado em: 22/06/2017
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10. l-Amino acid oxidase isolated from Calloselasma rhodostoma snake venom induces cytotoxicity and apoptosis in JAK2V617F-positive cell lines
ABSTRACT BACKGROUND: Myeloproliferative neoplasms are Philadelphia chromosome-negative diseases characterized by hyperproliferation of mature myeloid cells, associated or not with the Janus kinase 2 tyrosine kinase mutation, JAK2V617F. As there is no curative therapy, researchers have been investigating new drugs to treat myeloproliferative neoplasms, incl
Rev. Bras. Hematol. Hemoter.. Publicado em: 2016-06
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11. Multifocal primary cutaneous extranodal NK/T lymphoma nasal type
Abstract Nasal type extranodal NK/T-cell lymphoma is a distinct entity according to the World Health Organization classification. Although 60% to 90% of patients with this disease present with a destructive mass in the midline facial tissues, it may also primarily or secondarily involve extranasal sites, like the skin. We report the case of a 77-year-old pat
An. Bras. Dermatol.. Publicado em: 2016-04
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12. Virulence genes and antimicrobial resistance of Pasteurella multocida isolated from poultry and swine
Abstract Pasteurella multocida causes atrophic rhinitis in swine and fowl cholera in birds, and is a secondary agent in respiratory syndromes. Pathogenesis and virulence factors involved are still poorly understood. The aim of this study was to detect 22 virulence-associated genes by PCR, including capsular serogroups A, B and D genes and to evaluate the ant
Braz. J. Microbiol.. Publicado em: 2016-03