Motoneuron Model
Mostrando 1-12 de 14 artigos, teses e dissertações.
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1. Amplificação sináptica e interações não lineares na arborização dendrítica de modelos de motoneurônios / Synapti Amplication and Nonlinearities interations in the dendritics tree of motoneurons models
A partir de modelos de motoneurônios (MN) de geometria e estrutura complexa e capacidade de reproduzir as características de um motoneurônio real, este trabalho tem como objetivos verificar as diferenças funcionais entre sinapses proximais e distais, investigar as interações não lineares de ativações sinápticas e estudar a influência dos canais pe
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 23/04/2010
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2. Amplificação sináptica e interações não lineares na arborização dendrítica de modelos de motoneurônios / Synapti Amplication and Nonlinearities interations in the dendritics tree of motoneurons models
A partir de modelos de motoneurônios (MN) de geometria e estrutura complexa e capacidade de reproduzir as características de um motoneurônio real, este trabalho tem como objetivos verificar as diferenças funcionais entre sinapses proximais e distais, investigar as interações não lineares de ativações sinápticas e estudar a influência dos canais pe
Publicado em: 2010
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3. The immunomodulator glatiramer acetate influences spinal motoneuron plasticity during the course of multiple sclerosis in an animal model
The immunomodulador glatiramer acetate (GA) has been shown to significantly reduce the severity of symptoms during the course of multiple sclerosis and in its animal model - experimental autoimmune encephalomyelitis (EAE). Since GA may influence the response of non-neuronal cells in the spinal cord, it is possible that, to some extent, this drug affects the
Brazilian Journal of Medical and Biological Research. Publicado em: 2009-02
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4. Spinal motoneuron synaptic plasticity during the course of an animal model of multiple scierosis / Plasticidade sinaptica em motoneuronios alfa medulares de animais submetidos a encefalomielite autoimune experimental
Durante o curso da encefalomielite autoimmune experimental ocorre uma grave redução das funções motoras e sensitivas. Esses eventos têm sido classicamente atribuídos ao processo desmielinizante da doença. Em ratos, os sinais clínicos da doença desaparecem 5 dias após completa tetraplegia, indicando que o processo desmielinizante não é a única ca
Publicado em: 2007
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5. Computer modeling of a spinal reflex circuit
We used a set of properties of the interactions among the spinal neurons in order to develop a computer model for a spinal reflex circuit. The model equations take into account the synaptic characteristics of the somatodendritic membrane of neurons in a morphofunctional unity of the spinal reflex activity. This model is based on the idea that the responses o
Brazilian Journal of Physics. Publicado em: 2005-12
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6. Motoneuron survival is promoted by specific exercise in a mouse model of amyotrophic lateral sclerosis
Several studies using transgenic mouse models of familial amyotrophic lateral sclerosis (ALS) have reported a life span increase in exercised animals, as long as animals are submitted to a moderate-intensity training protocol. However, the neuroprotective potential of exercise is still questionable. To gain further insight into the cellular basis of the exer
Blackwell Science Inc.
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7. Reduced U snRNP assembly causes motor axon degeneration in an animal model for spinal muscular atrophy
Spinal muscular atrophy (SMA) is a motoneuron disease caused by reduced levels of survival motoneuron (SMN) protein. Previous studies have assigned SMN to uridine-rich small nuclear ribonucleoprotein particle (U snRNP) assembly, splicing, transcription, and RNA localization. Here, we have used gene silencing to assess the effect of SMN protein deficiency on
Cold Spring Harbor Laboratory Press.
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8. Rescue of adult mouse motoneurons from injury-induced cell death by glial cell line-derived neurotrophic factor.
Glial cell line-derived neurotrophic factor (GDNF) has been shown to rescue developing motoneurons in vivo and in vitro from both naturally occurring and axotomy-induced cell death. To test whether GDNF has trophic effects on adult motoneurons, we used a mouse model of injury-induced adult motoneuron degeneration. Injuring adult motoneuron axons at the exit
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9. Sexual Differentiation of the Spinal Nucleus of the Bulbocavernosus Is Not Mediated Solely by Androgen Receptors in Muscle Fibers
The spinal nucleus of the bulbocavernosus (SNB) neuromuscular system is a highly conserved and well-studied model of sexual differentiation of the vertebrate nervous system. Sexual differentiation of the SNB is currently thought to be mediated by the direct action of perinatal testosterone on androgen receptors (ARs) in the bulbocavernosus/levator ani muscle
The Endocrine Society.
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10. Exogenous heat shock cognate protein Hsc70 prevents axotomy-induced death of spinal sensory neurons
Elevation of intracellular heat shock protein (Hsp)70 increases resistance of cells to many physical and metabolic insults. We tested the hypothesis that treatment with Hsc70 can also produce that effect, using the model of axotomy-induced neuronal death in the neonatal mouse. The sciatic nerve was sectioned and in some animals purified bovine brain Hsc70 wa
Cell Stress Society International.
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11. Transgenic mice expressing an altered murine superoxide dismutase gene provide an animal model of amyotrophic lateral sclerosis.
Amyotrophic lateral sclerosis is a progressive neurodegenerative disorder primarily involving motoneurons. A subset of individuals with familial autosomal dominant forms of the disease have mutations of the copper/zinc superoxide dismutase (Cu/Zn SOD, SOD-1) gene, which encodes a ubiquitously expressed enzyme that plays a key role in oxygen free radical scav
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12. Estimating the strength of common input to human motoneurons from the cross-correlogram.
1. The relationship between the motor unit discharge pattern (rate and variability) and synchronization of motor unit pairs was studied in the first dorsal interosseus muscle of human subjects. In separate trials of up to 4 min duration, subjects voluntarily controlled the mean discharge rate of an identified motor unit at one of several prescribed rates (ra