Molecular Target
Mostrando 1-12 de 1843 artigos, teses e dissertações.
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1. In silico prediction of inhibitory potential of a punicalagin β-anomer against SARS-COV-2 main protease (MPRO)
The pandemic caused by the new coronavirus has resulted in a global health emergency and has prompted an urgent need for new treatment strategies. No target-specific drugs are currently available for SARS-CoV-2, but new drug candidates targeting the viral replication cycle are being explored. A prime target of drug-discovery efforts is the SARS-CoV-2 main pr
Química Nova. Publicado em: 2022
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2. What is new in non-chromatographic flavonoid purification?
Flavonoids are metabolites occurring in all plant tissues and present different biological activities. They occur in a mixture of similar polarity with laborious separation and purification processes, usually furnishing low yields. Semi-preparative chromatographic methods are universally employed procedures for their isolation. This paper discusses the state
Química Nova. Publicado em: 2022
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3. ATIVIDADE ANTIMICROBIANA DE QUITOSANAS E SEUS DERIVADOS: INFLUÊNCIA DAS CARACTERÍSTICAS ESTRUTURAIS
In recent years, there has been an increasing interest in the development of antimicrobial materials for different applications, especially in the biomedical field. In this context, chitosan is one of the most employed materials due to its highly attractive properties, such as biocompatibility, biodegradability, non-toxicity, and antimicrobial activity again
Química Nova. Publicado em: 2022
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4. Molecular mechanism of benign biliary stricture inhibition by rosiglitazone-activated peroxisome proliferator-activated receptor gamma
SUMMARY OBJECTIVE: The aim of this study was to investigate whether rosiglitazone-activated peroxisome proliferator-activated receptor gamma can inhibit the occurrence of benign biliary stricture and further elucidate the relevant molecular signaling mechanism. METHODS: The primary cultured rat biliary fibroblasts following experiments were performed using
Revista da Associação Médica Brasileira. Publicado em: 2022
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5. Low-dose paclitaxel modulates the cross talk between the JNK and Smad signaling in primary biliary fibroblasts
SUMMARY OBJECTIVE: The objective of this study was to explore the molecular mechanism underlying the occurrence of benign bile duct stricture and the target of low-dose paclitaxel in the prevention of benign bile duct stricture. METHODS: Under the stimulation of transforming growth factor beta 1, the expression of collagen type I and connective tissue grow
Revista da Associação Médica Brasileira. Publicado em: 2022
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6. Follow-up and outcome of the twelve-year experience in adult patients with acute promyelocytic leukemia
ABSTRACT Acute promyelocytic leukemia is a subtype of acute myeloid leukemia, characterized by the presence of neoplastic promyelocytes, due to the reciprocal balanced translocation between chromosomes 15 and 17. Currently, with the use of agents that act directly on this molecular change, such as all-trans retinoic acid and arsenic trioxide, APL has shifted
Hematol., Transfus. Cell Ther.. Publicado em: 2021-03
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7. Elevated Lipoprotein(A) in Children and Adolescents: Early Identification is Key for Successful Intervention
The usefulness of molecularly imprinted polymer assisted paper spray ionization mass spectrometry (MIP-PSI-MS) for the determination of methamphetamine in urine has been demonstrated. MIP-PSI-MS is a method in which a MIP is synthesized on the surface of a paper, producing a chemically selective paper surface with molecular recognition sites for a target ana
Int. J. Cardiovasc. Sci.. Publicado em: 2021-02
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8. Determining Methamphetamine in Urine by Molecularly Imprinted Polymer Assisted Paper Spray Ionization Mass Spectrometry
The usefulness of molecularly imprinted polymer assisted paper spray ionization mass spectrometry (MIP-PSI-MS) for the determination of methamphetamine in urine has been demonstrated. MIP-PSI-MS is a method in which a MIP is synthesized on the surface of a paper, producing a chemically selective paper surface with molecular recognition sites for a target ana
J. Braz. Chem. Soc.. Publicado em: 2021-02
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9. Identification of Potential Inhibitors of Severe Acute Respiratory Syndrome-Related Coronavirus 2 (SARS-CoV-2) Main Protease from Non-Natural and Natural Sources: A Molecular Docking Study
So far, there is neither a vaccine nor a specific antiviral drug to prevent or treat COVID-19 (coronavirus disease) infection. Recent studies have been done to investigate the capacity of human immunodeficiency virus type 1 (HIV-1) protease inhibitors be used in the treatment of COVID-19 patients. Some of those drugs have shown to be promising. Natural chemi
J. Braz. Chem. Soc.. Publicado em: 2020-12
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10. New Synthetic Quinolines as Cathepsin K Inhibitors
Cathepsin K is a papain-like cysteine protease and is responsible for collagen degradation in bone tissue and thus represents an important target for the development of new therapies for treating diseases such as osteoporosis. Quinolines are an important class of heterocyclic molecular leads with a great pharmacological potential and represent a relevant sca
J. Braz. Chem. Soc.. Publicado em: 2020-08
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11. The promise of growth hormone in sport: doped or duped
ABSTRACT Skeletal muscle is a target tissue of GH. Based on its anabolic properties, it is widely accepted that GH enhances muscle performance in sports. Athletic performance depends on muscle strength and the energy required to power muscle function. The energy required to power muscle function is derived from a continuum of anaerobic and aerobic sources. M
Arch. Endocrinol. Metab.. Publicado em: 10/01/2020
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12. HÁ ALGO NOVO NO RECONHECIMENTO MOLECULAR APLICADO À QUÍMICA MEDICINAL?
In Medicinal Chemistry, the knowledge, the study and the understanding of the intermolecular interactions inherent to the molecular recognition of a ligand by its target bioreceptor are essential. This is because understanding these interactions, which define the molecular complementarity between the two, is the key to analyze critically structure-activity r
Quím. Nova. Publicado em: 2020-01