Mlk
Mostrando 1-12 de 22 artigos, teses e dissertações.
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1. Infusão de morfina e cetamina, associada ou não à lidocaína, em gatas submetidas à ovariossalpingo-histerectomia
RESUMO O objetivo deste estudo foi avaliar os efeitos analgésicos transoperatórios da infusão contínua de morfina e cetamina, associada ou não à lidocaína, em gatas submetidas à OSH eletiva. Foram utilizadas 16 fêmeas adultas, hígidas, pré-medicadas com acepromazina (0,1mg/kg) e morfina (0,5mg/kg), ambas pela via intramuscular, induzidas com cetam
Arq. Bras. Med. Vet. Zootec.. Publicado em: 2020-01
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2. Emodin protects H9c2 cells from hypoxia-induced injury by up-regulating miR-138 expression
Myocardial infarction (MI) is a common presentation for ischemic heart disease, which is a leading cause of death. Emodin is a Chinese herbal anthraquinone used in several diseases. However, the effect of emodin in hypoxia-induced injury in cardiomyocytes has not been clearly elucidated. Our study aimed to clarify the functions of emodin in hypoxia-induced i
Braz J Med Biol Res. Publicado em: 25/02/2019
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3. Infusão contínua de morfina ou fentanil, associados à lidocaína e cetamina, em cães anestesiados com isofluorano
A técnica de analgesia multimodal, por meio da infusão contínua de fármacos, pode ser empregada para diminuir a incidência de sensibilização central durante a anestesia. Avaliaram-se as características cardiorrespiratórias, durante o procedimento de artroscopia de joelho, em cães anestesiados com isofluorano e monitorados por meio do índice biespe
Arq. Bras. Med. Vet. Zootec.. Publicado em: 2013-08
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4. Differential gene expressions of the MAPK signaling pathway in enterovirus 71-infected rhabdomyosarcoma cells
BACKGROUND: Mitogen-activated protein kinase (MAPK) signaling pathway plays an important role in response to viral infection. The aim of this study was to explore the function and mechanism of MAPK signaling pathway in enterovirus 71 (EV71) infection of human rhabdomyosarcoma (RD) cells. METHODS: Apoptosis of RD cells was observed using annexin V-FITC/PI bin
Braz J Infect Dis. Publicado em: 2013-08
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5. Analise Genetica da Concentracao de Potassio Eritrocitario em Bovinos.
No presente trabalho foi analisada a concentracao de K eritrocitario em 148 bovinos das racas: Pardo-Suico, Nelore, Pitangueiras, Gir e Girolanda. Todos os animais apresentaram baixa concentracao de K eritrocitario ou tipo LK. Houve a presenca dos tres subtipos de LK conhecidos: LLK ou concentracao baixa-baixa em 16,9% dos animais, variando de 7,0 a 15,9 meq
Pesquisa Agropecuaria Brasileira. Publicado em: 2011
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6. Medida de certeza na categorização multi-rótulo de texto e sua utilização como estratégia de poda do ranking de categorias
Dado um documento de entrada, um sistema de categorização multi-rótulo de texto tipicamente computa graus de crença para as categorias de um conjunto pré-definido, ordena as categorias por grau de crença, e atribui ao documento as categorias com grau de crença superior a um determinado limiar de poda. Idealmente, o grau de crença deveria informar a p
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 27/08/2010
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7. MLK-3 activates the SAPK/JNK and p38/RK pathways via SEK1 and MKK3/6.
Mixed lineage kinase-3 (MLK-3) is a 97 kDa serine/threonine kinase with multiple interaction domains, including a Cdc42 binding motif, but unknown function. Cdc42 and the related small GTP binding protein Rac1 can activate the SAPK/JNK and p38/RK stress-responsive kinase cascades, suggesting that MLK-3 may have a role in upstream regulation of these pathways
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8. A New Identity for MLK3 as an NIMA-related, Cell Cycle–regulated Kinase That Is Localized near Centrosomes and Influences Microtubule Organization
Although conserved counterparts for most proteins involved in the G2/M transition of the cell cycle have been found in all eukaryotes, a notable exception is the essential but functionally enigmatic fungal kinase NIMA. While a number of vertebrate kinases have been identified with catalytic domain homology to NIMA, none of these resemble NIMA within its exte
The American Society for Cell Biology.
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9. Mixed-Lineage Kinase 3 Delivers CD3/CD28-Derived Signals into the IκB Kinase Complex
The phosphorylation of IκB by the multiprotein IκB kinase complex (IKC) precedes the activation of transcription factor NF-κB, a key regulator of the inflammatory response. Here we identified the mixed-lineage group kinase 3 (MLK3) as an activator of NF-κB. Expression of the wild-type form of this mitogen-activated protein kinase kinase kinase (MAPKKK) i
American Society for Microbiology.
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10. Mixed Lineage Kinase Phosphorylates Transcription Factor E47 and Inhibits TrkB Expression to Link Neuronal Death and Survival Pathways*
E47 is a basic helix-loop-helix transcription factor involved in neuronal differentiation and survival. We had previously shown that the basic helix-loop-helix protein E47 binds to E-box sequences within the promoter of the TrkB gene and activates its transcription. Proper expression of the TrkB receptor plays a key role in development and function of the ve
American Society for Biochemistry and Molecular Biology.
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11. The MLK Family Mediates c-Jun N-Terminal Kinase Activation in Neuronal Apoptosis
Neuronal apoptotic death induced by nerve growth factor (NGF) deprivation is reported to be in part mediated through a pathway that includes Rac1 and Cdc42, mitogen-activated protein kinase kinases 4 and 7 (MKK4 and -7), c-Jun N-terminal kinases (JNKs), and c-Jun. However, additional components of the pathway remain to be defined. We show here that members o
American Society for Microbiology.
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12. Stimulation of NeuroD activity by huntingtin and huntingtin-associated proteins HAP1 and MLK2
NeuroD (ND) is a basic helix–loop–helix transcription factor important for neuronal development and survival. By using a yeast two-hybrid screen, we identified two proteins that interact with ND, huntingtin-associated protein 1 (HAP1) and mixed-lineage kinase 2 (MLK2), both of which are known to interact with huntingtin (Htt). Htt is a ubiquitous pr
National Academy of Sciences.