Medea
Mostrando 13-24 de 29 artigos, teses e dissertações.
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13. The Polycomb-group protein MEDEA regulates seed development by controlling expression of the MADS-box gene PHERES1
The Polycomb-group (PcG) proteins MEDEA, FERTILIZATION INDEPENDENT ENDOSPERM, and FERTILIZATION INDEPENDENT SEED2 regulate seed development in Arabidopsis by controlling embryo and endosperm proliferation. All three of these FIS-class proteins are likely subunits of a multiprotein PcG complex, which epigenetically regulates downstream target genes that w
Cold Spring Harbor Laboratory Press.
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14. Genes controlling fertilization-independent seed development in Arabidopsis thaliana
We have cloned two genes, FIS1 and FIS2, that control both fertilization independent seed development and postpollination embryo development in Arabidopsis. These genes confer female gametophytic phenotypes. FIS2 encodes a protein with a C2H2 zinc-finger motif and three putative nuclear localization signals, indicating that it is likely to be a transc
The National Academy of Sciences.
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15. The Population Dynamics of Maternal-Effect Selfish Genes
We use population genetic methods to describe the expected population dynamics of the selfish-gene chromosomal factor, Medea (maternal-effect dominant embryonic arrest), recently discovered in flour beetles, genus Tribolium. In the absence of deleterious effects on gross fecundity, Medea factors spread to fixation for all degrees of maternal-effect lethality
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16. Genetic Interaction of an Origin Recognition Complex Subunit and the Polycomb Group Gene MEDEA during Seed DevelopmentW⃞
The eukaryotic origin recognition complex (ORC) is made up of six subunits and functions in nuclear DNA replication, chromatin structure, and gene silencing in both fungi and metazoans. We demonstrate that disruption of a plant ORC subunit homolog, AtORC2 of Arabidopsis (Arabidopsis thaliana), causes a zygotic lethal mutant phenotype (orc2). Seeds of orc2 ab
American Society of Plant Biologists.
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17. Regulation of spalt expression in the Drosophila wing blade in response to the Decapentaplegic signaling pathway
Pattern formation depends on the acquisition of precise cellular identities due to the differential expression of transcription factors. Enhancers within regulatory regions integrate the positive and negative regulatory signals directing gene transcription. Here, we analyze the enhancer that drives expression of the Drosophila gene spalt in the wing blade. T
National Academy of Sciences.
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18. Interplay of Signal Mediators of Decapentaplegic (Dpp): Molecular Characterization of Mothers against dpp, Medea, and Daughters against dpp
Decapentaplegic (Dpp) plays an essential role in Drosophila development, and analyses of the Dpp signaling pathway have contributed greatly to understanding of the actions of the TGF-β superfamily. Intracellular signaling of the TGF-β superfamily is mediated by Smad proteins, which are now grouped into three classes. Two Smads have been identified in Droso
The American Society for Cell Biology.
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19. Control of fertilization-independent endosperm development by the MEDEA polycomb gene in Arabidopsis
Higher plant reproduction is unique because two cells are fertilized in the haploid female gametophyte. Egg and sperm nuclei fuse to form the embryo. A second sperm nucleus fuses with the central cell nucleus that replicates to generate the endosperm, a tissue that supports embryo development. To understand mechanisms that initiate reproduction, we isolated
The National Academy of Sciences.
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20. Maintenance of genomic imprinting at the Arabidopsis medea locus requires zygotic DDM1 activity
In higher plants, seed development requires maternal gene activity in the haploid (gametophytic) as well as diploid (sporophytic) tissues of the developing ovule. The Arabidopsis thaliana gene MEDEA (MEA) encodes a SET-domain protein of the Polycomb group that regulates cell proliferation by exerting a gametophytic maternal control during seed development. S
Cold Spring Harbor Laboratory Press.
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21. Genetic Screens to Identify Elements of the Decapentaplegic Signaling Pathway in Drosophila
Pathways for regulation of signaling by transforming growth factor-β family members are poorly understood at present. The best genetically characterized member of this family is encoded by the Drosophila gene decapentaplegic (dpp), which is required for multiple events during fly development. We describe here the results of screens for genes required to max
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22. Smad proteins regulate transcriptional induction of the SM22α gene by TGF-β
Smad proteins transduce signals from transforming growth factor-β (TGF-β) receptors and regulate transcription of target genes. TGF-β is implicated in the regulation of the smooth muscle cell specific gene SM22α, but little is known about how Smads are involved in SM22α gene transcription. In this report, we demonstrate that TGF-β activation of the SM2
Oxford University Press.
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23. Imprinting of the MEDEA polycomb gene in the Arabidopsis endosperm.
In flowering plants, two cells are fertilized in the haploid female gametophyte. Egg and sperm nuclei fuse to form the embryo. A second sperm nucleus fuses with the central cell nucleus that replicates to generate the endosperm, which is a tissue that supports embryo development. MEDEA (MEA) encodes an Arabidopsis SET domain Polycomb protein. Inheritance of
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24. An invariant aspartic acid in the DNA glycosylase domain of DEMETER is necessary for transcriptional activation of the imprinted MEDEA gene
Helix-hairpin-helix DNA glycosylases are typically small proteins that initiate repair of DNA by excising damaged or mispaired bases. An invariant aspartic acid in the active site is involved in catalyzing the excision reaction. Replacement of this critical residue with an asparagine severely reduces catalytic activity but preserves enzyme stability and stru
National Academy of Sciences.