Maspin
Mostrando 1-12 de 16 artigos, teses e dissertações.
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1. A expressão do maspin nos tumores mamários caninos: um estudo imuno-histoquímico e molecular
O serpin maspin, um supressor tumoral no câncer de mama foi descrito como inibidor de migração celular e indutor de adesão celular entre a membrana basal e a matriz extracelular resultando na inibição da metástase tumoral. Por outro lado, a alta expressão do maspin está relacionada com um mau prognóstico em outros tipos de câncer. Pouco se sabe so
Pesquisa Veterinária Brasileira. Publicado em: 2009-02
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2. Análise imunoistoquímica das proteínas maspin, p63 e bcl2 em tumor odontogênico queratocístico, cisto dentígero e ameloblastoma / Maspin, p63 e bcl2 in odontogenic keratocyst tumor, dentigerous cyst and ameloblastoma
Os cistos e tumores odontogênicos sempre tiveram grande importância dentro da Odontologia, seja pela grande prevalência clínica seja pelo grande acometimento do indivíduo afetado pela lesão. A nova classificação da Organização Mundial de Saúde trouxe a mudança de categoria do queratocisto, que recebe agora a nômina de tumor odontogênico querato
Publicado em: 2007
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3. Maspin expression in axilla-negative breast cancer: correlation with recurrence and prognostic factors. / Expressão da maspina no câncer mamário axila-negativo: correlação com a recidiva tumoral e com fatores prognósticos.
O câncer de mama é a neoplasia maligna de maior incidência em mulheres no mundo e no Brasil. A utilização de fatores prognósticos é importante na individualização dos grupos de prognóstico favorável e desfavorável. As metástases axilares são consideradas o fator mais relevante no câncer de mama, pois as pacientes com linfonodos axilares compro
Publicado em: 2007
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4. Maspin acts at the cell membrane to inhibit invasion and motility of mammary and prostatic cancer cells.
Maspin, a novel serine protease inhibitor (serpin), inhibits tumor invasion and metastasis of mammary carcinoma. We show here that recombinant maspin protein blocks the motility of these carcinoma cells in culture over 12 h, as demonstrated by time-lapse video microscopy. Lamellopodia are withdrawn but ruffling continues. Both exogenous recombinant maspin an
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5. Tissue-type plasminogen activator is a target of the tumor suppressor gene maspin
The maspin protein has tumor suppressor activity in breast and prostate cancers. It inhibits cell motility and invasion in vitro and tumor growth and metastasis in nude mice. Maspin is structurally a member of the serpin (serine protease inhibitors) superfamily but deviates somewhat from classical serpins. We find that single-chain tissue plasminogen activat
The National Academy of Sciences.
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6. Maspin Mediates Increased Tumor Cell Apoptosis upon Induction of the Mitochondrial Permeability Transition
Maspin is a unique serpin with the ability to suppress certain types of malignant tumors. It is one of the few p53-targeted genes involved in tumor invasion and metastasis. With this in mind, we attempted to study the molecular mechanism behind this tumor suppression. Maspin-expressing mammary tumors are more susceptible to apoptosis in both implanted mammar
American Society for Microbiology.
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7. Binding of Extracellular Maspin to β1 Integrins Inhibits Vascular Smooth Muscle Cell Migration*
Maspin is a serpin that has multiple effects on cell behavior, including inhibition of migration. How maspin mediates these diverse effects remains unclear, as it is devoid of protease inhibitory activity. We have previously shown that maspin rapidly inhibits the migration of vascular smooth muscle cells (VSMC), suggesting the involvement of direct interacti
American Society for Biochemistry and Molecular Biology.
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8. Maspin expression inhibits osteolysis, tumor growth, and angiogenesis in a model of prostate cancer bone metastasis
Emerging evidence indicates that tumor-associated proteolytic remodeling of bone matrix may underlie the capacity of tumor cells to colonize and survive in the bone microenvironment. Of particular importance, urokinase-type plasminogen activator (uPA) has been shown to correlate with human prostate cancer (PC) metastasis. The importance of this protease
National Academy of Sciences.
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9. Expression of maspin in prostate cells is regulated by a positive Ets element and a negative hormonal responsive element site recognized by androgen receptor
Prostate cancer is the most common cancer in men. The molecular mechanisms leading to its development are poorly understood. Maspin is a tumor-suppressing serpin expressed in normal breast and prostate epithelium. We have found that expression of maspin in normal and carcinoma-derived prostate epithelial cells is differentially regulated at the transcription
The National Academy of Sciences of the USA.
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10. Maspin is a tumour suppressor that inhibits breast cancer tumour metastasis in vivo
Maspin is a member of the serpin family of serine proteases and functions as a tumour suppressor. A study using a new syngeneic mouse model for breast cancer suggests that maspin can inhibit metastasis in vivo.
BioMed Central.
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11. Detection of the placental epigenetic signature of the maspin gene in maternal plasma
The discovery of fetal DNA in the plasma of pregnant women has opened up new approaches for noninvasive prenatal diagnosis and monitoring. Up to now, the lack of a fetal DNA marker that can be universally detected in maternal plasma has limited the clinical application of this technology. We hypothesized that epigenetic differences between the placenta and m
National Academy of Sciences.
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12. Nuclear and cytoplasmic Maspin expression in primary non‐small cell lung cancer
BMJ Group.