Mammary Gland Tumors
Mostrando 1-12 de 81 artigos, teses e dissertações.
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1. First description of basaloid carcinoma of the canine mammary gland: case report
RESUMO O objetivo deste relato de caso é descrever as características histopatológicas e imuno-histoquímicas do primeiro relato de carcinoma basaloide na glândula mamária canina. Duas cadelas foram atendidas com tumores na glândula mamária e foram submetidas à mastectomia. A avaliação microscópica demonstrou células epiteliais arranjadas em um p
Arq. Bras. Med. Vet. Zootec.. Publicado em: 14/06/2019
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2. RETROSPECTIVE STUDY OF 1,647 MAMMARY GLAND TUMORS IN DOGS / ESTUDO RETROSPECTIVO DE 1.647 TUMORES MAMÁRIOS EM CÃES
Mammary gland tumors are common in dogs and are the most common type of neoplasms of female dogs. The main purposes of this study were to establish the prevalence of the mammary gland tumors, as well as of its different histologic types (neoplastic and non-neoplastic), diagnosed in the Laboratório de Patologia Veterinária of the Universidade Federal de San
Publicado em: 2010
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3. Transcriptional up-regulation of PHLDA1 by 17β-estradiol in MCF-7 breast cancer cells
Most breast cancer risk factors are associated with prolonged exposure of the mammary gland to high levels of estrogens. The actions of estrogens are predominantly mediated by two receptors, ERα and ERβ, which act as transcription factors binding with high affinity to estrogen response elements in the promoter region of target genes. However, most target g
Brazilian Journal of Medical and Biological Research. Publicado em: 30/06/2008
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4. Expressão de PRSS11, MTSS1, CLPTM1, SMYD2, NOTCH1 e RPL37A em fatias de carcinoma de mama de cadelas e correlação com resposta à doxorrubicina in vitro / Expression of PRSS11, MTSS1, CLPTM1, SMYD2, NOTCH1 and RPL37A in slices of bitch mammary cancer and correlation with response to exposure doxorubicin in vitro
Mammary gland tumors are the most common neoplasias of bitches and doxorubicin is one the mainstay drugs used in their treatment. Neoadjuvant chemotherapy with doxorubicin not only reduces the primary tumor as well as allows an in vivo evaluation of tumor response. Predictive markers of response, if identified, might allow a tailored treatment of each patien
Publicado em: 2006
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5. Morphological changes induced by testosterone in the mammary glands of female Wistar rats
Increased levels of androgens in postmenopausal women are considered to be a risk factor for breast cancer. Testosterone, alone or in combination with estrogen, induces epithelial dysplasia and mammary tumors in Noble rats. Since this model of hormone-induced neoplasia has not been reported in other rat strains, we studied the effect of testosterone on the m
Brazilian Journal of Medical and Biological Research. Publicado em: 2005-04
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6. c-erbB-2 expression and nuclear pleomorphism in canine mammary tumors
The objective of the present investigation was to study the expression of c-erbB-2 and MIB-1 and try to associate them with morphological features of the cell such as nuclear pleomorphism, mitotic count and histological grade in a series of 70 canine mammary gland tumors, 22 of them benign and 48 malignant. Tumors were collected at the Veterinary Hospital of
Brazilian Journal of Medical and Biological Research. Publicado em: 2004-11
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7. Tenascin is a stromal marker for epithelial malignancy in the mammary gland.
Tenascin is an extracellular matrix glycoprotein that is not present in the normal mature rat mammary gland. The distribution of tenascin was examined by immunohistochemistry in mammary tumors from carcinogen-treated and untreated rats, in virus-induced mammary tumors from mice, and in a variety of mammary gland lesions from humans. Tenascin was detectable i
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8. Amplification of the neu/erbB-2 oncogene in a mouse model of mammary tumorigenesis
The neu (c-erbB-2, Her-2) protooncogene is amplified and overexpressed in 20–30% of human breast cancers. Although transgenic mouse models have illustrated the role of Neu in the induction of mammary tumors, Neu expression in these models is driven by a strong viral promoter of questionable relevance to the human disease. To ascertain whether expression of
The National Academy of Sciences.
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9. Suppression of mouse mammary tumor proviral DNA and protooncogene expression: association with nutritional regulation of mammary tumor development.
Chronic energy intake restriction (CEIR) reduces mouse mammary tumor virus (MMTV)-induced mammary tumors in C3H/Ou mice. Fewer than 10% of C3H/Ou mice developed mammary tumors during 88 wk of study when subjected to CEIR regardless of calorie source (fat vs. carbohydrate). By contrast, 100% of mice fed ad libitum diets relatively high in fat or carbohydrate
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10. PPARγ signaling exacerbates mammary gland tumor development
Breast cancer cell lines that express the nuclear peroxisome proliferator-activated receptor γ (PPARγ) can be prompted to undergo growth arrest and differentiation when treated with synthetic PPARγ ligands. To evaluate the therapeutic potential of increased PPARγ signaling in vivo, we generated transgenic mice that express a constitutively active form of
Cold Spring Harbor Laboratory Press.
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11. Inducible transgenics. New lessons on events governing the induction and commitment in mammary tumorigenesis
Breast cancer arises from multiple genetic events that together contribute to the established, irreversible malignant phenotype. The development of inducible tissue-specific transgenics has allowed a careful dissection of the events required for induction and subsequent maintenance of tumorigenesis. Mammary gland targeted expression of oncogenic Ras or c-Myc
BioMed Central.
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12. Histopathogenesis of 7,12-diemthylbenz(a)anthracene-induced rat mammary tumors.
The histopathogenesis and growth behavior of mammary tumors and dysplasias induced by a single intragastric dose of 7,12-dimethylbenz[a]anthracene in 50-day-old virgin female Lewis rats were examined both in situ and after transplantation into gland-free mammary fat pads of syngeneic hosts. Terminal mammary ductules are indicated as a site of origin of both