Lung Injuries
Mostrando 1-12 de 38 artigos, teses e dissertações.
-
1. Hypercapnia attenuates ventilator-induced lung injury through vagus nerve activation
Abstract Purpose: To investigate the role of vagus nerve activation in the protective effects of hypercapnia in ventilator-induced lung injury (VILI) rats. Methods: Male Sprague-Dawley rats were randomized to either high-tidal volume or low-tidal volume ventilation (control) and monitored for 4h. The high-tidal volume group was further divided into either
Acta Cir. Bras.. Publicado em: 25/11/2019
-
2. Glycogen synthase kinase-3 beta inhibitors protectagainst the acute lung injuries resulting from acute necrotizing pancreatitis
Abstract Purpose The research is intended for clarification of the efficacy as well as the underlying mechanism of GSK-3β inhibitors on the advancement of acute lung injuries in acute necrotizing pancreatitis (ANP) in rats. Methods Seventy-two rats were randomly divided into 6 groups: (1)ANP-vehicle; (2)ANP-TDZD-8;(3)ANP-SB216763;(4)Sham-vehicle;(5)Sham
Acta Cir. Bras.. Publicado em: 19/08/2019
-
3. Analysis of different levels of positive end-expiratory pressure during lung retrieval for transplantation: an experimental study
Atelectasis and inadequate oxygenation in lung donors is a common problem during the retrieval of these organs. Nevertheless, the use of high positive end-expiratory pressure (PEEP) is not habitual during procedures of lung retrieval. Twenty-one Sprague-Dawley male consanguineous rats were used in the study. The animals were divided into 3 groups according t
Braz J Med Biol Res. Publicado em: 15/07/2019
-
4. Evaluation of the Effects of Atorvastatin and Ischemic Postconditioning Preventing on the Ischemia and Reperfusion Injury: Experimental Study in Rats
Abstract Introduction: Reperfusion injury leads to systemic morphological and functional pathological alterations. Some techniques are already estabilished to attenuate the damage induced by reperfusion. Ischemic preconditioning is one of the standard procedures. In the last 20 years, several experimental trials demonstrated that the ischemic postconditioni
Braz. J. Cardiovasc. Surg.. Publicado em: 2018-02
-
5. The influence of allopurinol and post-conditioning on lung injuries induced by lower-limb ischemia and reperfusion in Wistar rats
Abstract Purpose: To analyze the effects of allopurinol and of post-conditioning on lung injuries induced by lower-limb ischemia and reperfusion. Methods: Thirty rats were used. They were divided in 5 groups: (1) group A: abdominal aortic dissection only, (2) group B: ischemia and reperfusion, (3) group C: administered allopurinol (100mg/Kg) a few hours b
Acta Cir. Bras.. Publicado em: 2017-09
-
6. Evaluation of the effects of ischemic preconditioning on the hematological parameters of rats subjected to intestinal ischemia and reperfusion
OBJECTIVES: Intestinal ischemia/reperfusion often leads to acute lung injury and multiple organ failure. Ischemic preconditioning is protective in nature and reduces tissue injuries in animal and human models. Although hematimetric parameters are widely used as diagnostic tools, there is no report of the influence of intestinal ischemia/reperfusion and isch
Clinics. Publicado em: 2015-01
-
7. Evolution of invasive pulmonary aspergillosis produced in mice treated with monoclonal antibodies anti GR-1/Ly-6G and infected with Aspergillus fumigatus strains which presented distincts patterns of production of elastase. / Evolução da aspergilose pulmonar invasiva produzida em camundongos tratados com anticorpos monoclonais anti GR-1/Ly-6G e infectados com amostras de Aspergillus fumigatus que apresentaram distintos padrões de produção de elastase
Invasive Pulmonary Aspergillosis (IPA) is an opportunistic fungal disease, caused mainly by Aspergillus fumigatus, that affects immunocompromised patients. To better understand this mycoses, we originally established in C57BL/6 mice an experimental model of neutrophils depletion by intraperitoneal inoculation of antibodies anti GR-1/Ly-6G, confirmed by total
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 02/04/2012
-
8. Avaliação de lesões e agentes bacterianos causadores de pericardite em suínos / Assessment of injuries and bacterial agents that cause pericarditis in pigs
O presente trabalho avaliou corações com pericardite e pulmões correspondentes através da análise anatomopatológica, bacteriológica, histopatológica e da técnica da Reação em Cadeia da Polimerase (PCR) a fim de identificar os agentes envolvidos no processo e correlacioná-los com as lesões macroscópicas presentes. O estudo foi realizado em quatr
Publicado em: 2011
-
9. Lung morphometry, collagen and elastin content: changes after hyperoxic exposure in preterm rabbits
INTRODUCTION: Elastic and collagen fiber deposition increases throughout normal lung development, and this fiber network significantly changes when development of the lung is disturbed. In preterm rats and lambs, prolonged hyperoxic exposure is associated with impaired alveolization and causes significant changes in the deposition and structure of elastic fi
Clinics. Publicado em: 2009-11
-
10. Efeito da solução salina hipertônica nas lesões resultantes da isquemia/reperfusão hepática: estudo experimental em ratos / Effect of hypertonic saline solution during ischemia/reperfusion injury in rat liver
Introduction: During liver ischemia, the drop in mitochondrial energy production leads to cellular damage, which is aggravated during restoration of blood supply. Besides local hepatic injury, the ischemia/reperfusion process can trigger a systemic inflammatory syndrome producing remote organ damage. To control these alterations in clinical conditions like l
Publicado em: 2008
-
11. Efeito da solução hipertônica sobre a expressão de proteínas ativadas por choque térmico (HSPs) e atividade de metaloproteinases (MMPs) teciduais na resposta inflamatória em pancreatite aguda experimental / Effect of the hypertonic solution (HS) in the expression of heat shock proteins (HSPs) and metalloproteinases activity (MMPs) in the lung in experimental pancreatitis
Acute Pancreatitis (AP) is an inflammatory process of the pancreas with variable involvement of other organs and systems. The lungs are the most common distant organs affected by severe acute pancreatitis. The immunomodulatory effects of hypertonic solution (HS) provide potential strategies to attenuate inappropriate inflammatory reactions. This study tested
Publicado em: 2007
-
12. Estudo de três estratégias de ventilação artificial protetora: alta freqüência, baixa freqüência e baixa freqüência associada à insuflação de gás traqueal, em modelo experimental de SARA / Comparing three protective mechanical ventilation strategies, HFOV, low-frequency-ventilation, and low-frequency-ventilation with TGI, in an ARDS experimental model
Introdução: Um dos principais objetivos na SARA é encontrar a melhor estratégia protetora de ventilação mecânica que minimize o stress pulmonar e otimize as trocas gasosas. Teoricamente, estas duas metas podem ser obtidas simultaneamente, evitando-se a hiperdistensão e colapso cíclico de unidades alveolares instáveis. Numa tentativa de radicalizar
Publicado em: 2007