Leishmania Major
Mostrando 1-12 de 485 artigos, teses e dissertações.
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1. N-Myristoyltransferases as antileishmanial targets: a piggyback approach with benzoheterocyclic analogues
Leishmaniasis is one of the neglected diseases that remain in need for pharmacological alternatives. In this context, N-Myristoyltransferases (NMT) arise as interesting targets to explore since they are involved in the co/post-translational processing of peptides which are responsible for host cell invasion. Studies that consider these enzymes as targets poi
Braz. J. Pharm. Sci.. Publicado em: 24/10/2019
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2. Essential Oils from Croton Species: Chemical Composition, in vitro and in silico Antileishmanial Evaluation, Antioxidant and Cytotoxicity Activities
Chemotherapy treatment of leishmaniasis is based on the use of pentavalent antimonials, but these drugs present low efficacy and high toxicity. In the search for new antileishmanial agents, essential oils (EOs) from four Croton species (C. argyrophylloides, C. jacobinensis, C. nepetifolius and C. sincorensis) were evaluated against Leishmania infantum chagas
J. Braz. Chem. Soc.. Publicado em: 24/10/2019
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3. Antileishmanial in vitro activity of essential oil from Myrciaria plinioides, a native species from Southern Brazil
In South American folk medicine members of the genus Myrciaria are used for the treatment of malaria, diarrhoea, asthma, inflammation and post-partum uterine cleansing. The aim of this work was to evaluate its antileishmanial properties (in vitro) of essential oil derived from leaves of Myrciaria plinioides D. Legrand, a plant species that is native in South
Braz. J. Pharm. Sci.. Publicado em: 24/10/2019
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4. INFECÇÃO POR Toxoplasma gondii, Neospora caninum, Leishmania major E Trypanosoma cruzi EM CÃES DO ESTADO DO PARÁ
Resumo Realizou-se inquérito sorológico para Toxoplasma gondii, Neospora caninum, Leishmania spp. e Trypanosoma cruzi em cães dos municípios de Castanhal e Belém, no Estado do Pará, e estudou-se a associação entre os animais sororeagentes e fatores como sexo, idade, acesso a rua e procedência dos animais. Foram utilizados 269 cães de diferentes ida
Ciênc. anim. bras.. Publicado em: 18/03/2019
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5. Ecology of phlebotomine sand flies in an area of leishmaniasis occurrence in the Xakriabá Indigenous Reserve, Minas Gerais, Brazil
Abstract INTRODUCTION: Leishmaniasis is a complex vector-borne infectious diseases caused by protozoan parasites in the genus Leishmania and spread by hematophagous phlebotomine sand flies (Diptera: Psychodidae, Phlebotominae). The aim of this study was to investigate the phlebotomine fauna, endophily and exophily of the species found, and possible influenc
Rev. Soc. Bras. Med. Trop.. Publicado em: 07/03/2019
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6. Study on Experimental Leishmanicidal Activity and in silico of Cytochalasin B
Leishmaniasis is a neglected infectious disease caused by different species of the Leishmania parasite and is one of the major public health problems in developing countries. Despite the progress in fundamental knowledge about the Leishmania parasite, current therapy against leishmaniasis is still unsatisfactory due to limited efficacy, prolonged treatment,
J. Braz. Chem. Soc.. Publicado em: 2019-03
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7. COMPOSIÇÃO QUÍMICA E ATIVIDADE ANTILEISHMANIA DE Tocoyena hispidula
Phytochemical investigation of the CHCl3 fraction from EtOH extract of Tocoyena hispidula (Rubiaceae) stem resulted in the isolation and identification of D-(+)-mannitol, lupenone, 3-O-acetyloleanolic acid, lapachol, dimethyl chelidonate, morindolide and four mixtures (M1-M4): M1 (palmitate, margarate, linoleate, oleate e stearate of the multiflorenyl, lupey
Quím. Nova. Publicado em: 2019-02
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8. Evaluation of a new brand of immunochromatographic test for visceral leishmaniasis in Brazil made available from 2018
ABSTRACT Immunochromatographic tests based on the recombinant antigen K39 represent a major advance in diagnosing visceral leishmaniasis (VL) in recent years. Some performance variations are expected and have occurred in the use of several commercial rapid tests, especially in different geographical settings. This is the first evaluation in the Americas of t
Rev. Inst. Med. trop. S. Paulo. Publicado em: 13/09/2018
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9. Lower galactosylation levels of the Lipophosphoglycan from Leishmania (Leishmania) major-like strains affect interaction with Phlebotomus papatasi and Lutzomyia longipalpis
BACKGROUND Leishmania major is an Old World species causing cutaneous leishmaniasis and is transmitted by Phlebotomus papatasi and Phlebotomus duboscqi. In Brazil, two isolates from patients who never left the country were characterised as L. major-like (BH49 and BH121). Using molecular techniques, these isolates were indistinguishable from the L. major ref
Mem. Inst. Oswaldo Cruz. Publicado em: 19/02/2018
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10. First case report of atypical disseminated cutaneous leishmaniasis in an opium abuser in Iran
ABSTRACT Leishmaniasis is a worldwide tropical infectious disease caused by different species of intracellular protozoa parasites of the genus Leishmania . Herein, we report a 78-year-old man with unusual diffuse cutaneous leishmaniasis (DCL) who had a history of opium abuse and chronic obstructive pulmonary disease (COPD). He had multiple papular, crusted a
Rev. Inst. Med. trop. S. Paulo. Publicado em: 15/02/2018
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11. In vitro evaluation of the anti-leishmanial activity and toxicity of PK11195
BACKGROUND Leishmaniasis, one of the most neglected diseases, is a serious public health problem in many countries, including Brazil. Currently available treatments require long-term use and have serious side effects, necessitating the development of new therapeutic interventions. Because translocator protein (TSPO) levels are reduced in Leishmania amazonen
Mem. Inst. Oswaldo Cruz. Publicado em: 05/02/2018
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12. In vitro antiparasitic activity and chemical composition of the essential oil from Protium ovatum leaves (Burceraceae)
ABSTRACT Leishmaniasis and trypanosomiasis are globally widespread parasitic diseases which have been responsible for high mortality rates. Since drugs available for their treatment are highly hepatotoxic, nephrotoxic and cardiotoxic, adherence to therapy has been affected. Thus, the search for new, more effective and safer drugs for the treatment of these d
An. Acad. Bras. Ciênc.. Publicado em: 16/10/2017