Knockout
Mostrando 1-12 de 2235 artigos, teses e dissertações.
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1. New insights of growth hormone (GH) actions from tissue-specific GH receptor knockouts in mice
ABSTRACT In order to provide new insights into the various activities of GH in specific tissues, recent advances have allowed for the generation of tissue-specific GHR knockout mice. To date, 21 distinct tissue-specific mouse lines have been created and reported in 28 publications. Targeted tissues include liver, muscle, fat, brain, bone, heart, intestine, m
Arch. Endocrinol. Metab.. Publicado em: 10/01/2020
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2. Efeitos do Treinamento Físico sobre o Miocárdio de Camundongos LDLr Knockout Ovariectomizadas: MMP-2 e -9, Colágeno I/III, Inflamação e Estresse Oxidativo
Resumo Fundamento: O surgimento da doença cardíaca coronariana aumenta com a menopausa, inatividade física e dislipidemia. Sabe-se que o treinamento físico promove a melhora das funções cardiovasculares Objectivo: Investigar os efeitos do treinamento físico aeróbico sobre o ventrículo esquerdo em camundongos LDL knockout ovariectomizadas. Método
Arq. Bras. Cardiol.. Publicado em: 2020-01
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3. Efeitos Antioxidantes do Euterpe Oleracea Mart. (Açaí) na Lesão de Isquemia-Reperfusão do Miocárdio em Ratos: Essa seria uma Boa Abordagem a ser Seguida?
Resumo Fundamento: O surgimento da doença cardíaca coronariana aumenta com a menopausa, inatividade física e dislipidemia. Sabe-se que o treinamento físico promove a melhora das funções cardiovasculares Objectivo: Investigar os efeitos do treinamento físico aeróbico sobre o ventrículo esquerdo em camundongos LDL knockout ovariectomizadas. Método
Arq. Bras. Cardiol.. Publicado em: 2020-01
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4. The liver injury following ischemia and reperfusion is worse in experimental knockout heterozygote mouse model for expression of connexin 43
Abstract Purpose: To evaluate that Connexin (Cx43) plays a role in lesions after hepatic ischemia/reperfusion (IR) injury. Methods: We use Cx43 deficient model (heterozygotes mice) and compared to a wild group. The groups underwent 1 hour ischemia and 24 hours reperfusion. The heterozygote genotype was confirmed by PCR. We analyzed the hepatic enzymes (AST
Acta Cir. Bras.. Publicado em: 13/12/2019
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5. Effects of Physical Training on the Myocardium of Oxariectomized LDLr Knockout Mice: MMP 2/9, Collagen I/III, Inflammation and Oxidative Stress
Resumo Fundamento: O surgimento da doença cardíaca coronariana aumenta com a menopausa, inatividade física e dislipidemia. Sabe-se que o treinamento físico promove a melhora das funções cardiovasculares Objectivo: Investigar os efeitos do treinamento físico aeróbico sobre o ventrículo esquerdo em camundongos LDL knockout ovariectomizadas. Método
Arq. Bras. Cardiol.. Publicado em: 21/10/2019
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6. MicroRNA-383-5p inhibits the progression of gastric carcinoma via targeting HDAC9 expression
MicroRNAs (miRNAs), as post-transcriptional regulators, have been reported to be involved in the initiation and progression of various types of cancer, including gastric cancer (GC). The present study aimed to investigate the role of miR-383-5p in gastric carcinogenesis. Cell viability was analyzed using CCK-8 kit. Annexin V-fluorescein isothiocyanate/propid
Braz J Med Biol Res. Publicado em: 29/07/2019
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7. Gene Deletion Leads to Improved Valinomycin Production by Streptomyces sp. CBMAI 2042
The genus Streptomyces represents one of the largest producers of molecules with antibiotic activity. The whole genome sequencing of the endophytic microorganism Streptomyces sp. CBMAI 2042 revealed 35 gene clusters encoding for secondary metabolism including 3 non-ribosomal peptide synthetases (NRPS) and 7 NRPS-hybrids. Combining genome mining and cultivati
J. Braz. Chem. Soc.. Publicado em: 2019-03
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8. Dry Extract of Passiflora incarnata L. leaves as a Cardiac and Hepatic Oxidative Stress Protector in LDLr-/- Mice Fed High-Fat Diet
ABSTRACT The control of dyslipidemia by using herbal products is an important subject for studies. In this study, we evaluated the effects of dry Passiflora incarnata L. extract over dyslipidemia, left ventricular hypertrophy, and hepatic oxidative stress of LDL receptor knockout mice (LDLr-/-). Forty 4-month old male LDLr-/- mice were distributed into four
Braz. arch. biol. technol.. Publicado em: 14/11/2018
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9. Current trends of genetics in apical periodontitis research
Abstract: Genetics is an emerging topic in endodontic research focusing on the host response regarding the pathogenesis of apical periodontitis (AP). A number of genetic epidemiological studies carried out by many investigators worldwide have shown evidence of an association between certain candidate genes and AP. Some studies have been conducted on knockout
Braz. oral res.. Publicado em: 18/10/2018
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10. Quorum sensing LuxS/autoinducer-2 inhibits Enterococcus faecalis biofilm formation ability
Abstract Objective: To investigate the relation between biofilm formation ability and quorum sensing gene LuxS/AI-2. Materials and Methods: Enterococcus faecalis (E. faecalis) standard strain ATCC 29212 was used in the study. Long flanking homology polymerase chain reaction method was used to build the LuxS gene knockout strain. Sequential culture turbidit
J. Appl. Oral Sci.. Publicado em: 04/10/2018
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11. Adrenergic receptor β3 is involved in the memory consolidation process in mice
Attention and emotion have a positive impact on memory formation, which is related to the activation of the noradrenergic system in the brain. The hippocampus and amygdala are fundamental structures in memory acquisition, which is modulated by noradrenaline through the noradrenergic receptors. Pharmacological studies suggest that memory acquisition depends o
Braz J Med Biol Res. Publicado em: 06/08/2018
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12. Strontium ranelate inhibits wear particle-induced aseptic loosening in mice
The imbalance between bone formation and osteolysis plays a key role in the pathogenesis of aseptic loosening. Strontium ranelate (SR) can promote bone formation and inhibit osteolysis. The aim of this study was to explore the role and mechanism of SR in aseptic loosening induced by wear particles. Twenty wild-type (WT) female C57BL/6j mice and 20 sclerostin
Braz J Med Biol Res. Publicado em: 10/07/2018