Iontophoresis
Mostrando 13-24 de 66 artigos, teses e dissertações.
-
13. Evaluation of zinc phthalocyanine tetrasulfonated (ZnPcS4) iontophoretic skin penetration and citotoxicity studies in culture of tumor cells. / Avaliação da penetração cutânea iontoforética da zinco ftalocianina tetrassulfonada (ZnPcS4) e estudos de citotoxicidade em cultura de células tumorais
A Terapia Fotodinâmica (TFD) é uma modalidade terapêutica inovadora para o tratamento de tumores cutâneos. As ftalocianinas têm sido utilizadas como fotossensibilizantes sistêmicos devido à sua alta afinidade ao tecido tumoral e seu efeito acentuado quando irradiadas com luz. No entanto, a lipossolubilidade e o baixo coeficiente de partilha óleo/águ
Publicado em: 2011
-
14. Estudo da microcirculação na hanseníase virchowiana com o uso da microscopia de luz ortogonal polarizada e com laser-doppler fluxometria / Microcirculation s research in leprosy with orthogonal polarization special imaging and laser doppler
Leprosy is an infectious disease with unique characteristics. One of them is the fact that it compromises not only the cutaneous and adnexial innervation, but also the innervation of the cutaneous microcirculation. Several articles indicate the impact of disautonomy on the microcirculatory level, citing the example of changes in vasomotor level. The present
Publicado em: 2010
-
15. Desenvolvimento de sistemas de liberação para a administração tópica passiva e iontoforética do minoxidil no tratamento da alopecia androgênica / Development of delivery systems for the topical passive and iontophoretic administration of minoxidil for the androgenic alopecia treatment
Given the hypothesis that polymeric microparticles can penetrate the skin barrier along the transfollicular route, and based on the evidence that iontophoresis is a method that can direct the delivery of drugs to the hair follicles, this work aimed to study the in vitro skin permeation of minoxidil sulfate (MXS), a drug used to treat androgenic alopecia, bot
Publicado em: 2009
-
16. Solid Lipid Nanoparticles as drug carrier for topical skin cancer treatment. / Nanopartículas Lipídicas Sólidas (NLS) como carreadores de fármacos para o tratamento tópico do câncer de pele
A Doxorrubicina (DOX) é um dos antineoplásicos mais utilizados no tratamento de tumores sólidos, como os de pele. Sua baixa penetração cutânea e instabilidade frente aos tecidos biológicos impedem, no entanto, sua aplicação tópica e localizada. Dentro deste contexto, o objetivo deste trabalho foi direcionar e aumentar a penetração cutânea da DOX
Publicado em: 2009
-
17. Princípios básicos e aplicação da iontoforese na penetração cutânea de fármacos
Physicochemical constraints severely limit the number of molecules that can be considered as candidates for transdermal delivery. Iontophoresis is a non-invasive technique in which a weak electric current is used to enhance the penetration of molecules into or through the skin. In this review the underlying mechanisms that drive iontophoresis and the impact
Química Nova. Publicado em: 2008
-
18. Desenvolvimento de formulações iontoforéticas semi-sólidas para o tratamento de tumores cutâneos: estudo in vitroem cultura de células tumorais / Development of semi-solid iontophoretic formulations for treatment of cutaneous tumor: in vitro studies on tumor cell culture.
O objetivo deste trabalho foi estudar a permeação iontoforética da Doxorrubicina (DOX) em formulações semi-sólidas e testar a citotoxicidade destas formulações em cultura de células de melanoma com e sem a aplicação de corrente elétrica de baixa intensidade. O estudo de liberação da DOX das formulações (gel de Hidroxietilcelulose ? HEC, gel d
Publicado em: 2007
-
19. Efeito das diferenças sexuais e da capacidade aeróbica na resposta sudorípara de homens e mulheres
Human capacity to dissipate heat in hot environments depends mainly on sweat secretion and evaporation. Studies have shown that men have greater sweating capacity and produce more sweat in response to similar stimulation than women. However, due to sexual dimorphism and typical differences in VO2máx, it is not known yet if sudorific differences are really s
Publicado em: 2007
-
20. Iontophoresis experimental model as a choice of drug delivery during the acute treatment and chronic hemophilic arthropathy / Estudo experimental da iontoforese como via de administração de farmacos no quadro agudo de hemartrose e no modelo de artropatia cronica hemofilica
A iontoforese é uma técnica de transferência de drogas mediadas por um fluxo elétrico. Os benefícios terapêuticos da introdução de medicamentos pela iontoforese incluem a diminuição de efeitos colaterais sistêmicos aos quais o paciente apresenta intolerância e a ação localizada do medicamento podendo este estar em maior concentração na área
Publicado em: 2006
-
21. Comparison of sweat rate during graded exercise and the local rate induced by pilocarpine
Centrally stimulated sweat rate produced by graded exercise until exhaustion was compared to the local sweat rate induced by pilocarpine, often used as a sweating index for healthy individuals. Nine young male volunteers (22 ± 4 years) were studied in temperate environment in two situations: at rest and during progressive exercise with 25 W increases every
Brazilian Journal of Medical and Biological Research. Publicado em: 2005-07
-
22. Iontophoresis generates an antimicrobial effect that remains after iontophoresis ceases.
Iontophoresis required chlorine-containing compounds in the medium for effective microbial population reduction and killing. After iontophoresis ceased, the antimicrobial effect generated by iontophoresis remained but slowly decreased. Antimicrobial effects of iontophoresis may be related to the generation of short-lived chlorine-containing compounds.
-
23. Iontophoretic Application of Adenine Arabinoside Monophosphate to Herpes Simplex Virus Type 1-Infected Hairless Mouse Skin
Several antiviral agents were applied topically or by iontophoresis to hairless mouse skin inoculated with herpes simplex virus type 1 (HSV-1), and the chemotherapeutic effectiveness was evaluated. Topical application of iododeoxyuridine, arabinoside A, and adenine arabinoside monophosphate (ara-AMP) moderately decreased the average lesion score, number of m
-
24. Quantification, qualification, and microbial killing efficiencies of antimicrobial chlorine-based substances produced by iontophoresis.
The dependence of microbial killing on chloride ions present in solutions undergoing iontophoresis is addressed. A 400-microA current was applied to vials containing synthetic urine or saline, and the production of chlorine-based substances (CBSs) was detected by the N,N-diethyl-p-phenylene diamine colorimetric method. It was found that as the time of curren