Interleukin 21
Mostrando 13-24 de 254 artigos, teses e dissertações.
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13. Assessment of the Potential Role of Silymarin Alone or in Combination with Vitamin E and/ or Curcumin on the Carbon Tetrachloride Induced Liver Injury in Rat
ABSTRACT The aim of this study was to investigate the effective role of silymarin either alone or in a combination with vitamin E and/or curcumin against the toxic impact of carbon tetrachloride (CCl4) induced liver injury The results revealed that administration of silymarin alone or in a combination with vitamin E and/or curcumin for 21 consecutive days, 2
Braz. arch. biol. technol.. Publicado em: 2015-12
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14. Haptoglobin gene polymorphisms and interleukin-6 and -8 levels in patients with sickle cell anemia
BACKGROUND: Haptoglobin genotypes, and interleukin-6 and -8 participate in the pathophysiology of sickle cell anemia. The expression of cytokines is regulated by genetic mechanisms however the effect of haptoglobin polymorphisms on these cytokines is not fully understood. This study aimed to compare the frequency of haptoglobin genotypes and the interleukin-
Rev. Bras. Hematol. Hemoter.. Publicado em: 2015-10
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15. Effects of omega-3 supplementation on interleukin and neurotrophin levels in an animal model of schizophrenia
RESUMONovos estudos sugerem que os ácidos graxos poliinsaturados, como o ômega-3, podem reduzir os sintomas da esquizofrenia. O presente estudo avaliou o efeito preventivo do ômega-3 sobre os níveis de interleucinas (IL) e o fator neurotrófico derivado do cérebro (BDNF) em cérebros de ratos jovens submetidos a um modelo de esquizofrenia. O tratamento
An. Acad. Bras. Ciênc.. Publicado em: 2015-08
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16. Interaction of an opportunistic fungus Purpureocillium lilacinum with human macrophages and dendritic cells
IntroductionPurpureocillium lilacinum is emerging as a causal agent of hyalohyphomycosis that is refractory to antifungal drugs; however, the pathogenic mechanisms underlying P. lilacinum infection are not understood. In this study, we investigated the interaction of P. lilacinum conidia with human macrophages and dendritic cells in vitro.MethodsSpores of a
Rev. Soc. Bras. Med. Trop.. Publicado em: 2014-10
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17. Possible roles of COX-1 in learning and memory impairment induced by traumatic brain injury in mice
People who suffer from traumatic brain injury (TBI) often experience cognitive deficits in spatial reference and working memory. The possible roles of cyclooxygenase-1 (COX-1) in learning and memory impairment in mice with TBI are far from well known. Adult mice subjected to TBI were treated with the COX-1 selective inhibitor SC560. Performance in the open f
Braz J Med Biol Res. Publicado em: 16/09/2014
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18. The hydrogen sulfide donor, Lawesson's reagent, prevents alendronate-induced gastric damage in rats
Our objective was to investigate the protective effect of Lawesson's reagent, an H2S donor, against alendronate (ALD)-induced gastric damage in rats. Rats were pretreated with saline or Lawesson's reagent (3, 9, or 27 µmol/kg, po) once daily for 4 days. After 30 min, gastric damage was induced by ALD (30 mg/kg) administration by gavage. On the last day of t
Braz J Med Biol Res. Publicado em: 16/08/2013
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19. Associação do gene IL23A com a proteção ao diabetes mellitus tipo 1 autoimune / IL23A gene association with protection to type 1 autoimmune diabetes mellitus
Introdução: Diabetes tipo 1A(DM1A) é uma doença causada pela destruição autoimune das células beta. Em adição aos linfócitos T helper 1(Th1) e Th2, um subtipo específico de células T helper recentemente descrito, Th17, caracterizado pela produção da interleucina 17(IL-17A), IL-17F e IL-22, está também envolvido na imunidade adaptativa e autoi
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 10/08/2012
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20. Estudo do IL-7R na leucemia linfóide aguda pediátrica de linhagem T / Study of IL-7R in chilldhood T-cell acute lymphoblastic leukemia
A IL-7 é uma citocina essencial para o desenvolvimento, sobrevivência, e proliferação dos timócitos prematuros normais no timo e linfócitos T maduros nos órgãos linfoides periféricos. O receptor da IL-7 é um heterodímero constituído pela IL-7Ra (codificado pelo gene IL7R) e IL-2Ry. A IL-2Ry participa também dos receptores da IL-2, IL-4, IL-9, IL
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 27/01/2012
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21. Estudo da região promotora do gene da interleucina (IL-21) e do poliformismo do gene tirosina fosfatase, tipo não receptor 22 (PTPN22): associação com auto-anticorpos em pacientes portadores de diabetes mellitos tipo 1A / Allelic variant in IL21 promoter region, C1858T PTPN22 frequency and autoantibodies in Brazilian type 1A diabetes patients
As citocinas têm papel importante como mediadores através das respostas imunológicas. A Interleucina-21, importante regulador dos linfócitos T e B, é produzida por linfócitos CD4 ativados, e está implicada na patogênese do diabetes autoimune em modelo animal, o NOD. A região promotora da IL-21, que contempla sítios de controle da expressão gênica
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 11/08/2011
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22. Multiple cytokine expression profiles reveal immune-based differences in occult hepatitis B genotype H-infected Mexican Nahua patients
A high prevalence of occult hepatitis B (OHB) genotype H infections has been observed in the native Mexican Nahua population. In addition, a low incidence of hepatitis B virus (HBV)-associated hepatocellular carcinoma has been described in Mexico. The immune response to infection among OHB-infected patients has been poorly evaluated in vivo. Therefore, we as
Memórias do Instituto Oswaldo Cruz. Publicado em: 2011-12
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23. Education, tobacco smoking, alcohol consumption, and IL-2 and IL-6 gene polymorphisms in the survival of head and neck cancer
The association of education, tobacco smoking, alcohol consumption, and interleukin-2 (IL-2 +114 and -384) and -6 (IL-6 -174) DNA polymorphisms with head and neck squamous cell carcinoma (HNSCC) was investigated in a cohort study of 445 subjects. IL-2 and IL-6 genotypes were determined by real-time PCR. Cox regression was used to estimate hazard ratios (HR)
Brazilian Journal of Medical and Biological Research. Publicado em: 2011-10
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24. A high corticosterone/DHEA-s ratio in young rats infected with Trypanosoma cruzi is associated with increased susceptibility
We have previously established that young male rats are more susceptible to the effects of Trypanosoma cruzi infection than adult rats. To explore underlying age-associated differences in disease outcome, we simultaneously assessed hormone levels and cytokine release throughout the acute infection period in young and adult rats infected with T. cruzi. Young
Memórias do Instituto Oswaldo Cruz. Publicado em: 2011-06