Intensive Insulin Therapy
Mostrando 1-12 de 21 artigos, teses e dissertações.
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1. Gestational diabetes and overt diabetes first diagnosed in pregnancy: characteristics, therapeutic approach and perinatal outcomes in a public healthcare referral center in Brazil
ABSTRACT Objective: To describe the clinical characteristics, management, and fetal outcomes of patients diagnosed with gestational diabetes mellitus (GDM) or overt diabetes (OD) during pregnancy who followed up at a public healthcare referral center in Brazil. Materials and methods: A retrospective cohort study based on the medical records of women diagno
Arch. Endocrinol. Metab.. Publicado em: 2021-02
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2. Intensive treatment of hyperglycemia in the acute phase of myocardial infarction: the tenuous balance between effectiveness and safety – a systematic review and meta-analysis of randomized clinical trials
RESUMO INTRODUÇÃO No infarto agudo do miocárdio (IAM), cada incremento de 18 mg/dl (1 mmol/L) se associa a um aumento de 3% na mortalidade. As estratégias de redução da glicemia tentadas até o momento, entretanto, não trouxeram resultados animadores. METODOLOGIA Foram pesquisadas nas bases de dados Medline (PubMed) e Cochrane Library os ensaios cl�
Rev. Assoc. Med. Bras.. Publicado em: 2019-01
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3. Short-term insulin intensive therapy decreases MCP-1 and NF-κB expression of peripheral blood monocyte and the serum MCP-1 concentration in newlydiagnosed type 2 diabetics
ABSTRACT Objective To observe the effect of short-term insulin intensive treatment on the monocyte chemoattractant protein-1 (MCP-1) as well as on the nuclear factor-kappa B (NF-κB) expression of peripheral blood monocyte. This is also in addition to observing the serum MCP-1 level in newlydiagnosed type 2 diabetic patients and probing its anti-inflammatio
Arch. Endocrinol. Metab.. Publicado em: 05/04/2018
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4. Permanent neonatal diabetes by a new mutation in KCNJ11: unsuccessful switch to sulfonylurea
Permanent neonatal diabetes (PNDM) can result from activating heterozygous mutations in KCNJ11 gene, encoding the Kir6.2 subunit of the pancreatic ATP-sensitive potassium channels (KATP). Sulfonylureas promote KATP closure and stimulate insulin secretion, being an alternative therapy in PNDM, instead of insulin. Male, 20 years old, diagnosed with diabetes at
Arch. Endocrinol. Metab.. Publicado em: 28/08/2015
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5. Human pancreatic islet transplantation: an update and description of the establishment of a pancreatic islet isolation laboratory
Type 1 diabetes mellitus (T1DM) is associated with chronic complications that lead to high morbidity and mortality rates in young adults of productive age. Intensive insulin therapy has been able to reduce the likelihood of the development of chronic diabetes complications. However, this treatment is still associated with an increased incidence of hypoglycem
Arch. Endocrinol. Metab.. Publicado em: 2015-04
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6. Impact of glycemic control on the incidence of acute kidney injury in critically ill patients: a comparison of two strategies using the RIFLE criteria
OBJECTIVE: To compare the renal outcome in patients submitted to two different regimens of glycemic control, using the RIFLE criteria to define acute kidney injury. INTRODUCTION: The impact of intensive insulin therapy on renal function outcome is controversial. The lack of a criterion for AKI definition may play a role on that. METHODS: Included as the subj
Clinics. Publicado em: 2010-06
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7. Alterações lipídicas no paciente séptico: análise da participação da resistência insulínica nas alterações metabólicas / Study of metabolic acidosis in patients with severe sepsis or septic shock
Metabolic disturbances are very frequent among critical care patients. Severe sepsis and septic shock are clinical conditions responsible for a great number of patients admitted to ICU. Severe sepsis and septic shock mortality rates remain high instead of new approaches developed in last decades. Intensive glycemic control appeared to be an important adjuvan
Publicado em: 2010
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8. Avaliação do metabolismo de lipídes em diabéticos tipo 1, normolipidêmicos e sem complicações microvasculares e macrovasculares significativas através de nanoemulsão lipídica artificial / Evaluation of lipid metabolism in normolipidemic type 1 diabetes individuals without significant clinical microvascular and macrovascular complications through artificial lipid nanoemulsion
INTRODUTION: people with type 1 diabetes mellitus (DM1) have progressively neuro-vascular complications. Factors that increase the risk of coronary artery disease hypertension, dislipidemia and advanced age explains part of increased cardiovascular mortality, however some DM1 died of early coronary artery disease and often do not have atherosclerosis classic
Publicado em: 2008
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9. Eventos adversos na administração de dieta enteral em unidade de terapia intensiva: análise comparativa entre o volume prescrito e o administrado. / Adverse events related to the administration of enteral diet in the unit of intensive care: analyses to compare the volume precribed with the administrated.
It talks about a study of prospective, descriptive and quantitative approach, which has as objectives to compare the volume of enteral diet which was prescribed with the one administrated to the interned patients in the Unit of Intensive Care (UIC); to compare the daily caloric necessities (DCN) of the patients with the prescribed caloric necessities (PCN) a
Publicado em: 2006
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10. Comportamentos de autocuidado em diabetes tipo 1 : estratégias para a promoção da adesão
A adesão ao tratamento em diabetes tipo 1 representa um desafio, sobretudo ao jovem , que se vê diante da necessidade de priorizar ações de autocuidado em um momento da vida em que a saúde é percebida como atributo natural e não como algo a ser construído. Ao longo do século XX, a abordagem do diabetes tipo 1 avançou desde a descoberta da insulina,
Publicado em: 2006
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11. Acute intensive insulin therapy exacerbates diabetic blood-retinal barrier breakdown via hypoxia-inducible factor-1α and VEGF
Acute intensive insulin therapy is an independent risk factor for diabetic retinopathy. Here we demonstrate that acute intensive insulin therapy markedly increases VEGF mRNA and protein levels in the retinae of diabetic rats. Retinal nuclear extracts from insulin-treated rats contain higher hypoxia-inducible factor-1α (HIF-1α) levels and demonstrate increa
American Society for Clinical Investigation.
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12. Abnormal meal carbohydrate disposition in insulin-dependent diabetes. Relative contributions of endogenous glucose production and initial splanchnic uptake and effect of intensive insulin therapy.
Postprandial hyperglycemia in insulin-deficient, insulin-dependent diabetic subjects may result from impaired suppression of endogenous glucose production and/or abnormal disposition of meal-derived glucose. To investigate the relative contributions of these processes and to determine whether 2 wk of near normoglycemia achieved by using intensive insulin the