Inhibitor
Mostrando 1-12 de 15245 artigos, teses e dissertações.
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1. Management of mild congenital deficiency of Factor XI with a Factor XI inhibitor in pregnancy: A clinical case
Hematology, Transfusion and Cell Therapy. Publicado em: 2022
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2. Effects of sodium-glucose cotransporter-2 inhibitors on nutritional status in heart failure with reduced ejection fraction
SUMMARY OBJECTIVE: This study aimed to evaluate the effects of sodium-glucose cotransporter-2 inhibitors on nutritional status in patients with heart failure with reduced ejection fraction. METHODS: The sodium-glucose cotransporter-2 inhibitor treatment was initiated in 153 patients with heart failure with reduced ejection fraction who were symptomatic des
Revista da Associação Médica Brasileira. Publicado em: 2022
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3. In silico prediction of inhibitory potential of a punicalagin β-anomer against SARS-COV-2 main protease (MPRO)
The pandemic caused by the new coronavirus has resulted in a global health emergency and has prompted an urgent need for new treatment strategies. No target-specific drugs are currently available for SARS-CoV-2, but new drug candidates targeting the viral replication cycle are being explored. A prime target of drug-discovery efforts is the SARS-CoV-2 main pr
Química Nova. Publicado em: 2022
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4. Reperfusion Strategies in Acute Myocardial Infarction: State of the Art
Abstract ST elevation myocardial infarction (STEMI) is a highly prevalent condition worldwide. Reperfusion therapy is strongly associated with the prognosis of STEMI and must be performed with a high standard of quality and without delay. A systematic review of different reperfusion strategies for STEMI was conducted, including randomized controlled trials t
International Journal of Cardiovascular Sciences. Publicado em: 2022
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5. MicroRNA-375 inhibits laryngeal squamous cell carcinoma progression via targeting CST1
Abstract Objective: This study aims to explore the effect and mechanism of miR-375 in Laryngeal Squamous Cell Carcinoma (LSCC) cell progression. Methods: LSCC cells (LSC-1 and TU177) were transfected with miR-375-mimic, miR-375-inhibitor or miR-375-mimic + oe-CST1. The expression of miR-375, CST1, MMP-2, and MMP-9 was measured. The effect of miR-375-mimic,
Brazilian Journal of Otorhinolaryngology. Publicado em: 2022
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6. First-line biologic therapy with tumor necrosis factor inhibitors for psoriatic arthritis: a prospective observational study
ABSTRACT BACKGROUND: Psoriatic arthritis (PsA) is a chronic inflammatory disease that affects multiple joints. It is associated with psoriasis and treated with synthetic and biologic drugs. OBJECTIVE: The objective of this study was to assess the outcomes of patients who received biologic therapy with tumor necrosis factor (TNF) inhibitors in terms of effe
Sao Paulo Medical Journal. Publicado em: 2022
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7. Molecular mechanism of benign biliary stricture inhibition by rosiglitazone-activated peroxisome proliferator-activated receptor gamma
SUMMARY OBJECTIVE: The aim of this study was to investigate whether rosiglitazone-activated peroxisome proliferator-activated receptor gamma can inhibit the occurrence of benign biliary stricture and further elucidate the relevant molecular signaling mechanism. METHODS: The primary cultured rat biliary fibroblasts following experiments were performed using
Revista da Associação Médica Brasileira. Publicado em: 2022
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8. Inhibitor of gibberellin biosynthesis in ornamental peppers
RESUMO O objetivo deste estudo foi avaliar se a inibição da biossíntese de giberelinas afeta as características morfofisiológicas das espécies Capsicum baccatum e Capsicum annuum destinadas ao uso ornamental, cultivadas em vasos em casa de vegetação. As plantas foram conduzidas em vaso de 2,7 L em casa de vegetação, organizadas em delineamento inte
Horticultura Brasileira. Publicado em: 2022
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9. Soft figs shelf life increasing with and 1-methylcyclopropene and cold storage
ABSTRACT The best sensorial Brown Turkey figs for the fresh market are the ones harvested soft. However, at this maturity stage, they have a very short shelf life, from two to seven days, depending on environmental conditions, which make their marketing very difficult. This research’s goal was to increase the shelf life of soft 'Roxo de Valinhos' figs, a '
Revista Ceres. Publicado em: 2022
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10. Antitumor activity of irinotecan with ellagic acid in C6 glioma cells
SUMMARY OBJECTIVE: Irinotecan-based combination chemotherapies in malignant gliomas need to be examined. The aim of this study was to investigate the synergetic effect of ellagic acid, a natural polyphenolic antioxidant compound, with irinotecan, an inhibitor of topoisomerase I enzyme, on the growth, cadherin switch, and angiogenic processes of a glioma cel
Revista da Associação Médica Brasileira. Publicado em: 2022
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11. Clinical use of tranexamic acid: evidences and controversies
Abstract Tranexamic acid (TXA) significantly reduces blood loss in a wide range of surgical procedures and improves survival rates in obstetric and trauma patients with severe bleeding. Although it mainly acts as a fibrinolysis inhibitor, it also has an anti-inflammatory effect, and may help attenuate the systemic inflammatory response syndrome found in some
Brazilian Journal of Anesthesiology. Publicado em: 2022
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12. Outcome of Gastroesophageal Reflux Therapy in Children with Persistent Otitis Media with Effusion
Abstract Introduction Otitis media with effusion (OME) is considered one of the most common disorders that affect children during the first years of life. There are many risk factors of persistent middle ear effusion; one of these risk factors is gastroesophageal reflux. Association between persistent OME and gastroesophageal reflux diseases (GERDs) could b
International Archives of Otorhinolaryngology. Publicado em: 2022