Immunotoxicity
Mostrando 1-12 de 13 artigos, teses e dissertações.
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1. Essential oil of the leaves of Eugenia sulcata preserve myocardial contractility and does not present immunotoxicity
The essential oil of the leaves of Eugenia sulcata, in the Myrtaceae family, has a demonstrated antihypertensive effect, but its effects on heart muscle and its toxicity have not yet been elucidated. Little chemical or biological data are available for E. sulcata, whether emphasizing the beneficial effects or the pharmacological security of this species. Thi
Braz. J. Pharm. Sci.. Publicado em: 30/09/2019
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2. Efeitos da geoprópolis de Melipona fasciculata Smith sobre a microbiota cariogênica: prospecção de um bioproduto. / Effects of geopropolis Melipona fasciculata Smith on the cariogenic microbiota: mining a byproduct.
O presente trabalho teve por objetivo avaliar a atividade antimicrobiana do extrato de geoprópolis da Melipona fasciculata Smith sobre Streptococcus mutans (no estado planctônico e de biofilme), Lactobacillus acidophilus e Candida albicans, identificar as classes químicas presentes nos extratos e investigar a ação antibacteriana in vitro de um gel a bas
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 15/07/2010
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3. Estudo dos mecanismos de ação da hidroquinona e fenol sobre o recrutamento leucocitário em respostas inflamatórias / Study of mechanisms of action of hydroquinone and phenol on leukocyte recruitment in inflammatory response
Hydroquinone (HQ) is one of the metabolites of benzene responsible for the toxic effects of exposure to solvent, as well as being part of the diet, medicines, tobacco and polluting the environment. Considering the immunotoxicity of this substance, our laboratory has investigated the role of exposure to HQ by prolonged period of time on acute inflammatory res
Publicado em: 2008
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4. Impacto da exposição crônica ao fenol no metabolismo, fisiologia e resposta ao estresse de juvenis de Matrinxã (Brycon cephalus: Teleostei; Characidae).
The contamination of the aquatic environment has been responsible for considerable losses on natural stocks of several marine and freshwater fish. Among the many classes of chemicals dumped in aquatic system, the phenols present a great harmful potential due to its many modes of action. These include: genotoxicity, haematotoxicity, immunotoxicity, citotoxici
Publicado em: 2005
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5. Establishment of an Immunoglobulin M Antibody-Forming Cell Response Model for Characterizing Immunotoxicity in Primary Human B Cells
Rodent models have been extensively utilized to identify putative human immunotoxicants; however, even when immunotoxicity is established, uncertainty remains whether the effects are predictive of human risk. Therefore, the objective of this study was to establish a polyclonal immunoglobulin M (IgM) antibody-forming cell (AFC) response model to directly char
Oxford University Press.
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6. Effects of (E)-5-(2-bromovinyl)-2'-deoxyuridine on proliferation of human fibroblasts, peripheral blood mononuclear cells, and granulocyte-monocyte progenitor cells in vitro.
Inhibition of human fibroblasts, granulocyte-monocyte progenitor cells, and lymphocytes was observed at (E)-5-(2-bromovinyl)-2'-deoxyuridine concentrations ranging from 21 to 197 micrograms/ml. These concentrations were 10- to 100-fold above usual serum concentrations after oral administration. (E)-5-(2-Bromovinyl)-2'-deoxyuridine compares favorably with cur
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7. Patterns of Immunotoxicity Associated with Chronic as Compared with Acute Exposure to Chemical or Physical Stressors and their Relevance with Regard to the Role of Stress and with Regard to Immunotoxicity Testing
Previous studies have demonstrated that the stress response induced by some drugs and chemicals contributes in a predictable way to alteration of particular immunological parameters in mice. It has not been determined if mice can become tolerant or habituated with regard to the stress response and consequent immunological effects. Addressing this issue was t
Oxford University Press.
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8. Inhibition of mitogen-induced blastogenesis in human lymphocytes by T-2 toxin and its metabolites.
Concentrations of T-2, HT-2, 3'-OH T-2, 3'-OH HT-2, T-2 triol, and T-2 tetraol toxins which inhibited [3H]thymidine uptake in mitogen-stimulated human peripheral lymphocytes by 50% were 1.5, 3.5, 4.0, 50, 150, and 150 ng/ml, respectively. The results suggested that the initial hydrolysis of T-2 toxin and the hydroxylation of T-2 toxin to 3'-OH T-2 toxin did
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9. Preparation and characterization of monoclonal antibodies to the trichothecene mycotoxin T-2.
Two mouse immunoglobulin G1 monoclonal antibodies that bind to the trichothecene mycotoxin T-2 were prepared. These antibodies, designated 12C12 and 15H6, had affinities for T-2 of 3.5 X 10(6) and 5.8 X 10(7) liters/mol, respectively. A competitive inhibition enzyme immunoassay that employed these antibodies had a sensitivity for T-2 of 50 ng per assay. Both
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10. In vitro and in vivo immunomodulatory effects of anti-Pneumocystis carinii drugs.
The anti-Pneumocystis carinii drug effects on mitogen-, antigen-, and interleukin-2-induced proliferative responses and on natural killer (NK) cell-mediated activity were analyzed in vivo (rats) and in vitro (normal human peripheral blood mononuclear cells). Splenocytes derived from in vivo piritrexim- and clindamycin-treated rats showed a significant inhibi
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11. The aryl hydrocarbon receptor: a perspective on potential roles in the immune system
The aryl hydrocarbon receptor (AHR) is a protein best known for its role in mediating toxicity. Over 30 years of research has uncovered additional roles for the AHR in xenobiotic metabolism and normal vascular development. Activation of the AHR has long been known to cause immunotoxicity, including thymic involution. Recent data suggesting a role for the AHR
Blackwell Science Inc.
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12. Systemic Immunoresponses in Mice after Repeated Exposure of Lungs to Spores of Streptomyces californicus
Microbial growth in moisture-damaged buildings is associated with respiratory and other symptoms in the occupants. Streptomyces spp. are frequently isolated from such buildings. In the present study, we evaluated the responses of mice after repeated exposure to spores of Streptomyces californicus. Mice were exposed via intratracheal instillation to six doses
American Society for Microbiology.