Immunology Tolerance
Mostrando 1-12 de 14 artigos, teses e dissertações.
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1. Nível de expressão tumoral da indoleamine 2,3-dioxigenase (IDO) como marcador biológico e preditor de metástase em pacientes com tumor carcinoide típico broncopulmonar / Tumor Expression Level of Indoleamine 2,3 dioxygenase as Biological Marker and Metastasis Predictor in Patients with Typical Bronchopulmonary Carcinoid Tumors
Os tumores carcinoides típicos broncopulmonares (TCTB) são considerados neoplasias bem diferenciadas e as menos agressivas dentro do espectro dos tumores neuroendócrinos. Entretanto, metástases linfonodais e hematogênicas tem sido encontradas em número considerável de casos e não existem, até o momento, estudos relacionados aos mecanismos de escape
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 08/12/2011
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2. Cytokines and T-Lymphocute count in patients in the acute and chronic phases of Bartonella bacilliformis infection in an endemic area in peru: a pilot study
Human Bartonellosis has an acute phase characterized by fever and hemolytic anemia, and a chronic phase with bacillary angiomatosis-like lesions. This cross-sectional pilot study evaluated the immunology patterns using pre- and post-treatment samples in patients with Human Bartonellosis. Patients between five and 60 years of age, from endemic areas in Peru,
Revista do Instituto de Medicina Tropical de São Paulo. Publicado em: 2011-06
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3. Dendritic cells and the 60kDa heat shock protein (Hsp60): strategies for immunoregulation in the mouse immune system / Células dendríticas e a proteína de choque térmico 60KDA (HSP60): estratégias para imunorregulação do sistema imune murino
The induction of tolerance to allotransplant without the help of immunosupressive drugs is one of the major challenges in immunology. Considering the tolerogenic potential of dendritic cells and the immunoregulatory activity of Hsp60, our objective was to determine the capacity of dendritic cells (DCs) of inducing immunoregulation through the interaction wit
Publicado em: 2008
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4. Morphometric study of immune cellular and pre-acinar axis remodeling by type V collagen induction on bronchiolite obliterans model / Estudo morfométrico da imunidade celular e remodelamento no eixo pré-acinar na indução do colágeno tipo V em um modelo de bronquiolite obliterante
A minority of patients with remodeling process of lungs following bronquiolite obliterante (BO) responds to corticosteroids. So, we sought to validate the importance of type V collagen (tVc) tolerance from immunization as option in BO model treatment. Througt of morphometric analyses, we have mensured for the dimensions, the collagen and cell infiltration de
Publicado em: 2007
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5. Effects of chronic and prolonged solar radiation in immunologic system of fishermen from Recife, Brazil / Efeitos da radiação solar crônica e prolongada sobre o sistema imunológico de pescadores do Recife
Introduction: The ultraviolet radiation effects on the human immunological system are highly complex, disturbing some components of immune response. Objective: The objective of this study was to evaluate the clinical, histopathological and immunological effects from solar radiation in male fishermen with more than 10 years of uninterrupted activity. Methods:
Publicado em: 2007
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6. Vascularized thymic lobe transplantation in miniature swine: Thymopoiesis and tolerance induction across fully MHC-mismatched barriers
As the major site of self-nonself discrimination in the immune system, the thymus, if successfully transplanted, could potentially carry with it the induction of central tolerance to any other organ or tissue from the same donor. We have recently developed a technique for transplantation of an intact, vascularized thymic lobe (VTL) in miniature swine. In the
National Academy of Sciences.
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7. In vivo induction of antigen-specific transplantation tolerance to Qa1a by exposure to alloantigen in the absence of T-cell help.
A goal of transplantation immunology is to be able to induce antigen-specific tolerance in transplant recipients. In the present study we describe an in vivo model of antigen-specific transplantation tolerance to skin allografts using mice congenic at Qa1, a ubiquitously expressed class I-like molecule encoded to the right of H-2D. B6 mice are deficient in Q
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8. Induction of allogeneic mixed chimerism by immature dendritic cells and bone marrow transplantation leads to prolonged tolerance to major histocompatibility complex disparate allografts
Mixed chimerism has been shown to lead to prolonged major histocompatibility complex (MHC) disparate allograft survival and immune-specific tolerance; however, traditional conditioning regimes often involve myeloablation, which may pose a significant safety risk. In this study we examined the use of donor C57BL/6 (H-2b) immature dendritic cells (imDCs) to to
Blackwell Science Inc.
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9. Immunological suppression by human CD8+ T cells is receptor dependent and HLA-DQ restricted.
Mechanisms of specific immunologic unresponsiveness or tolerance and their regulation by the major histocompatibility complex remain central issues in immunology. Recent findings that potentially reactive anti-self T cells are not completely clonally deleted in the thymus and that specific immunological unresponsiveness can be acquired in certain infectious
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10. Potential role of macrophages as immunoregulators of pregnancy
The role of the maternal immune system during pregnancy has focused mainly on the aspect of immune tolerance to the invading trophoblast and, therefore, fetus. While this is a critical aspect of reproductive immunology, it is also important to consider the function of the maternal immune system in the promotion of implantation and maintenance of pregnancy. A
BioMed Central.
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11. Selective targeting of the immune response in autoimmune demyelination.
Recent developments in molecular and cellular immunology have led to the formulation of refined models that describe how tolerance to self-antigens is broken and autoimmunity develops. This knowledge can now be used to develop alternative approaches to conventional immunosuppression for the treatment of autoimmune demyelinating disorders. The ideal therapy w
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12. Conventional immunosuppression and co-stimulation blockade.
Organ transplantation has become an accepted and successful therapeutic intervention for many patients with end-stage organ disease. Current conventional immunosuppressive regimens achieve very good short-term allograft survival but long-term outcomes are less than adequate. Furthermore, non-specific immunosuppression has its attendant side-effects including