Immune Evasion
Mostrando 1-12 de 235 artigos, teses e dissertações.
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1. Immunohistochemical evaluation of HLA-G and FoxP3+ T regulatory cells in oral cavity and lower lip squamous cell carcinomas
Abstract: Human Leukocyte Antigen G (HLA-G) is a molecule involved in the tumor immunosuppression and also in the generation of regulatory T (Treg) cells, thus leading to evasion to the immune system host, and consequently, contributing to tumor progression in several cancers. The aim of this study was to evaluate the immunoexpression of HLA-G by tumor cells
Braz. oral res.. Publicado em: 11/04/2019
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2. Current approaches to immunotherapy in noncolorectal gastrointestinal malignancies
Noncolorectal gastrointestinal (GI) malignancies are among the most frequently diagnosed cancers. Despite the undeniable progress in systemic treatments in recent decades, further improvements using cytotoxic chemotherapy seem unlikely. In this setting, recent discoveries regarding the mechanism underlying immune evasion have prompted the study of molecules
Clinics. Publicado em: 18/10/2018
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3. Human polyomaviruses and cancer: an overview
The name of the family Polyomaviridae, derives from the early observation that cells infected with murine polyomavirus induced multiple (poly) tumors (omas) in immunocompromised mice. Subsequent studies showed that many members of this family exhibit the capacity of mediating cell transformation and tumorigenesis in different experimental models. The transfo
Clinics. Publicado em: 11/10/2018
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4. Molecular epidemiology of Streptococcus agalactiae isolated from mastitis in Brazilian dairy herds
Abstract Streptococcus agalactiae is one of the most common pathogens leading to mastitis in dairy herds worldwide; consequently, the pathogen causes major economic losses for affected farmers. In this study, multilocus sequence typing (MLST), genotypic capsular typing by multiplex polymerase chain reaction (PCR), and virulence gene detection were performed
Braz. J. Microbiol.. Publicado em: 2017-07
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5. Subversion of immunoproteasome subunit expression in dengue virus serotype 2-infected HepG2 cells
Abstract: INTRODUCTION: Infection with all serotypes of dengue virus (DV) results in augmented antigen presentation by MHC class I molecules. However, the upregulation of immunoproteasome subunits only results from infection with two serotypes. This study aims to elucidate changes in the expression of immunoproteasome subunits resulting from infection with
Rev. Soc. Bras. Med. Trop.. Publicado em: 2017-02
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6. Expression of co-stimulatory molecules CD80 and CD86 is altered in CD14 + HLA-DR + monocytes from patients with Chagas disease following induction by Trypanosoma cruzi recombinant antigens
Abstract INTRODUCTION The relationships between monocytes and lymphocytes through MHC class II molecules and costimulatory, are of utmost importance for the production of an efficient immune response. In this work, we assessed the expression of surface molecules CD80 and CD86 on CD14+HLA-DR+ monocytes from patients with Chagas disease. METHODS: The study
Rev. Soc. Bras. Med. Trop.. Publicado em: 2016-10
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7. Effects of lung cancer cell-associated B7-H1 on T-cell proliferation in vitro and in vivo
B7 homolog 1 (B7-H1) is the most potent immunoinhibitory molecule in the B7 family. In this study, we examined the effects of tumor-associated B7-H1 on T-cell proliferation in lung cancer. The expression of B7-H1 in human adenocarcinoma A549 and mouse Lewis lung carcinoma (LLC) cells were examined by flow cytometry. To assess the in vitro effect of tumor-ass
Braz J Med Biol Res. Publicado em: 20/06/2016
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8. The remarkable journey of adaptation of the Plasmodium falciparum malaria parasite to New World anopheline mosquitoes
Plasmodium falciparum originated in Africa, dispersed around the world as a result of human migration and had to adapt to several different indigenous anopheline mosquitoes. Anophelines from the New World are evolutionary distant form African ones and this probably resulted in a more stringent selection of Plasmodium as it adapted to these vectors. It is tho
Mem. Inst. Oswaldo Cruz. Publicado em: 2014-08
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9. Interação de Leptospira interrogans com o sistema proteolítico plasminogênio/plasmina: análise, caracterização e possíveis implicações na infecção. / Leptospira interrogans interactions with the plasminogen/plasmin proteolytic system: analysis, characterization and possible implications for the infection.
Leptospirosis is a zoonosis caused by pathogenic bacteria from genus Leptospira. Despite its importance, the pathogenicity and virulence remain to be elucidated. The leptospires do not present known proteases able to degrade extracellular matrix, an activity essential for the penetration and dissemination within the hosts. Therefore, we proposed the investig
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 05/10/2012
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10. Trichinella spiralis shares epitopes with human autoantigens
Like other helminths, Trichinella spiralis has evolved strategies to allow it to survive in the host organism, including the expression of epitopes similar to those present in either expressed or hidden host antigens. To identify T. spiralis-derived antigens that are evolutionarily conserved in the parasite and its host and that could be responsible for its
Memórias do Instituto Oswaldo Cruz. Publicado em: 2012-06
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11. Transcription of interferon stimulated genes in response to porcine rubulavirus infection in vitro
Porcine rubulavirus (PoRV) is an emerging virus causing meningo-encephalitis and reproductive failures in pigs. Little is known about the pathogenesis and immune evasion of this virus; therefore research on the mechanisms underlying tissue damage during infection is essential. To explore these mechanisms, the effect of PoRV on the transcription of interferon
Brazilian Journal of Microbiology. Publicado em: 2011-09
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12. Evasion of immune responses by Trypanosoma cruzi, the etiological agent of Chagas disease
Infection with the protozoan parasite Trypanosoma cruzi leads to Chagas disease, which affects millions of people in Latin America. Infection with T. cruzi cannot be eliminated by the immune system. A better understanding of immune evasion mechanisms is required in order to develop more effective vaccines. During the acute phase, parasites replicate extensiv
Brazilian Journal of Medical and Biological Research. Publicado em: 2011-02