Hypogonadism
Mostrando 25-36 de 116 artigos, teses e dissertações.
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25. Hypogonadotropic Hypogonadism Revisited
Impaired testicular function, i.e., hypogonadism, can result from a primary testicular disorder (hypergonadotropic) or occur secondary to hypothalamic-pituitary dysfunction (hypogonadotropic). Hypogonadotropic hypogonadism can be congenital or acquired. Congenital hypogonadotropic hypogonadism is divided into anosmic hypogonadotropic hypogonadism (Kallmann s
Clinics. Publicado em: 2013
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26. Medical management of non-obstructive azoospermia
Non-obstructive azoospermia is diagnosed in approximately 10% of infertile men. It represents a failure of spermatogenesis within the testis and, from a management standpoint, is due to either a lack of appropriate stimulation by gonadotropins or an intrinsic testicular impairment. The former category of patients has hypogonadotropic hypogonadism and benefit
Clinics. Publicado em: 2013
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27. Twenty-five milligrams of clomiphene citrate presents positive effect on treatment of male testosterone deficiency - a prospective study
INTRODUCTION: Male testosterone deficiency is associated with bad sexual function and quality of life (QoL). The aim of this study was to determine whether a daily dose of 25 mg clomiphene citrate (CC) is effective in stimulating the endogenous testosterone production pathway and to address the applicability of this medication as a therapeutic option for sym
Int. braz j urol.. Publicado em: 2012-08
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28. Visual acuity and retinal function in patients with Bardet-Biedl syndrome
OBJECTIVE: Bardet-Biedl syndrome is a genetic, multisystem disorder that causes severe visual impairment. This condition is characterized by retinal dystrophy, obesity, digit anomalies, renal disease, and hypogonadism. The purpose of this study was to analyze visual acuity and full-field electroretinogram findings in patients with the Bardet-Biedl syndrome p
Clinics. Publicado em: 2012
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29. The novel p.E89K mutation in the SRY gene inhibits DNA binding and causes the 46,XY disorder of sex development
Male sex determination in humans is controlled by the SRY gene, which encodes a transcriptional regulator containing a conserved high mobility group box domain (HMG-box) required for DNA binding. Mutations in the SRY HMG-box affect protein function, causing sex reversal phenotypes. In the present study, we describe a 19-year-old female presenting 46,XY karyo
Brazilian Journal of Medical and Biological Research. Publicado em: 2011-04
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30. Mutações inativadoras dos genes PROK2 e PROKR2 em pacientes com hipogonadismo hipogonadotrófico isolado / PROK2 and PROKR2 inactivating mutations in patients with idiopathic hypogonadotropic hypogonadism
O sistema da procineticina desempenha um papel importante na migração dos neurônios secretores de GnRH e na neurogênese do bulbo olfatório. Camundongos com ablação dos genes que codificam a procineticina 2 (PROK2) e seu receptor (PROKR2) apresentaram fenótipos semelhantes ao da síndrome de Kallmann descrita em humanos. Mutações inativadoras nos ge
Publicado em: 2011
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31. Serum levels of hypothalamic-pituitary-testicular axis hormones in men with or without prostate cancer or atypical small acinar proliferation
INTRODUCTION: Substantial controversy exists regarding the association between testosterone serum levels and prostate cancer. OBJECTIVE: To evaluate the levels of hypothalamic-pituitary-testicular axis hormones in the sera of men with prostate cancer and atypical small acinar proliferation as well as those with normal biopsies. METHODS: A study cohort of 186
Clinics. Publicado em: 2011
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32. Racial differences in hypogonadal improvement and prostate-specific antigen levels in hypogonadal men treated with testosterone replacement therapy
PURPOSE: To observe hypogonadal men undergoing testosterone replacement therapy (TRT) and assess racial differences in hypogonadal improvement and prostate-specific antigen (PSA) levels. MATERIALS AND METHODS: In a retrospective analysis, 75 hypogonadal men were followed for an average 34 months after initiating TRT. Total testosterone and PSA levels were as
International braz j urol. Publicado em: 2010-12
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33. O impacto neuroendocrinológico do uso prolongado de morfina por vias espinal e oral no tratamento da dor crônica / Neuroendocrine and metabolic effect of the treatment of non-cancer pain patients with morphine used through oral or spinal route
Abstract: The hypothalamic-pituitary function, the quality of life and the pain severity of 57 non-cancer pain patients treated or not with morphine through the oral or spinal route were prospective analyzed. Twenty were females (18 - 60 yr) and 37, males (18 - 45 yr). Nineteen were treated with 60 to 120mg/day of morphine sulfate trough the oral route (oral
Publicado em: 2010
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34. Estudo dos genes TTF-1 e EAP1 em pacientes com distúrbios puberais centrais e avaliação neurológica e neurocognitiva de pacientes com hamartoma hipotalâmico / Analysis of TTF-1 and EAP1 genes in patients with central pubertal disorders and neurologic and neurocognitive evaluation of patients with hypothalamic hamartoma
O mecanismo de controle da secreção de GnRH inclui diversas vias neuronais. Estudos em modelos animais identificaram genes que codificam fatores de transcrição, tais como TTF-1 (thyroid transcription factor 1) e EAP1 (enhanced at puberty), que atuam no controle transcricional de genes codificadores de fatores excitatórios (KiSS1 e GnRH) e inibitórios (
Publicado em: 2010
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35. Parâmetros mecânicos, físicos e químicos na avaliação de mandíbulas de ratos deficientes em esteróides sexuais / Mechanical, physical and chemical parameters in mandible evaluation of sex steroid deficiency rats
The increase in the life expectancy has been raising the occurrence of common degenerative alterations in aging population, as osteoporosis. This systemic disease is also frequent in hypogonadism and affects the bone metabolism, included mandibular bone. The aim of this study was to evaluate how sex steroid deficiency, induced by orchiectomy (ORX) or ovariec
Publicado em: 2009
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36. Influência do hipogonadismo sobre a fibrose e apoptose na parede vesical de ratos jovens orquiectomizados e ratos senis. / Influence of hypogonadism in the fibrosis and apoptoses in the vesical wall of senile and orchiectomized rats.
Objetivo: A bexiga pode ser considerada um órgão-alvo para a ação da testosterona. Diminuição dos níveis do hormônio com o envelhecimento tem sido associada com disfunção vesical. Ratos senis e orquiectomizados vêm sendo empregados como modelo animal para estudo dos efeitos do hipoandrogenismo, os quais, devido à ação direta e indireta da testo
Publicado em: 2009